Search Results - "Marie, Suely K N"
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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
Published in Proceedings of the National Academy of Sciences - PNAS (28-08-2012)“…Glioblastoma multiforme (GBM) is the most aggressive of the astrocytic malignancies and the most common intracranial tumor in adults. Although the epidermal…”
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2
Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes
Published in Scientific reports (14-01-2021)“…Glioblastoma (GBM) is the most aggressive brain primary malignancy. Toll-like receptor 4 (TLR4) has a dual role in cell fate, promoting cell survival or death…”
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3
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
Published in Journal of neuro-oncology (01-07-2008)“…The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important to optimize treatment…”
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4
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Published in Nature neuroscience (01-08-2017)“…Microglia are the macrophages of the CNS, with innate neuroimmune function, and play important roles in tissue homeostasis, CNS development and…”
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Mitochondria Transcription Factor A: A Putative Target for the Effect of Melatonin on U87MG Malignant Glioma Cell Line
Published in Molecules (Basel, Switzerland) (09-05-2018)“…The disruption of mitochondrial activity has been associated with cancer development because it contributes to regulating apoptosis and is the main source of…”
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6
Extracellular Matrix Proteome Remodeling in Human Glioblastoma and Medulloblastoma
Published in Journal of proteome research (01-10-2021)“…Medulloblastomas (MBs) and glioblastomas (GBMs) are high-incidence central nervous system tumors. Different origin sites and changes in the tissue…”
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7
CD99 is upregulated in placenta and astrocytomas with a differential subcellular distribution according to the malignancy stage
Published in Journal of neuro-oncology (01-08-2014)“…In the present study, we searched for genes highly expressed in placenta and that could contribute to the establishment and maintenance of a malignant…”
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8
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer
Published in International journal of molecular sciences (23-07-2019)“…Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3…”
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LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells
Published in International journal of molecular sciences (01-08-2021)“…Lysyl oxidase-like 3 (LOXL3), belonging to the lysyl oxidase family, is responsible for the crosslinking in collagen or elastin. The cellular localization of…”
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10
Pompe disease in a Brazilian series: clinical and molecular analyses with identification of nine new mutations
Published in Journal of neurology (01-11-2009)“…Pompe disease (glycogen storage disease type II or acid maltase deficiency) is an inherited autosomal recessive deficiency of acid α-glucosidase (GAA), with…”
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11
Cellular Model of Malignant Transformation of Primary Human Astrocytes Induced by Deadhesion/Readhesion Cycles
Published in International journal of molecular sciences (19-04-2022)“…Astrocytoma is the most common and aggressive tumor of the central nervous system. Genetic and environmental factors, bacterial infection, and several other…”
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12
Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas
Published in Cancer gene therapy (01-08-2023)“…Members of the HDAC family are predictive biomarkers and regulate the tumorigenesis in several cancers. However, the role of these genes in the biology of…”
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13
CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion
Published in International journal of molecular sciences (06-03-2019)“…Glioblastoma (GBM) is the most aggressive type of brain tumor, with an overall survival of 17 months under the current standard of care therapy. CD99, an…”
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14
The chromatin remodeler complex ATRX-DAXX-H3.3 and telomere length in meningiomas
Published in Clinical neurology and neurosurgery (01-11-2021)“…ATRX-DAXX-H3.3 chromatin remodeler complex is a well known epigenetic factor responsible for the heterochromatin maintenance and control. ATRX is an important…”
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15
Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas
Published in International journal of cancer (15-02-2008)“…We have performed cDNA microarray analyses to identify gene expression differences between highly invasive glioblastoma multiforme (GBM) and typically benign…”
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16
Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes
Published in Frontiers in endocrinology (Lausanne) (30-04-2020)“…Using a discovery/validation approach we investigated associations between a panel of genes selected from a transcriptomic study and the estimated glomerular…”
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Melatonergic system-based two-gene index is prognostic in human gliomas
Published in Journal of pineal research (01-01-2016)“…Gliomas, the most common primary brain tumors in adults, are classified into four malignancy grades according to morphological features. Recent studies have…”
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18
Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy
Published in Brain (London, England : 1878) (01-11-2009)“…Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling…”
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N-acetylcysteine Counteracts Adipose Tissue Macrophage Infiltration and Insulin Resistance Elicited by Advanced Glycated Albumin in Healthy Rats
Published in Frontiers in physiology (22-09-2017)“…Advanced glycation endproducts elicit inflammation. However, their role in adipocyte macrophage infiltration and in the development of insulin resistance,…”
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Selection of suitable housekeeping genes for expression analysis in glioblastoma using quantitative RT-PCR
Published in BMC molecular biology (03-03-2009)“…Considering the broad variation in the expression of housekeeping genes among tissues and experimental situations, studies using quantitative RT-PCR require…”
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