Search Results - "Marichal, P"

State-of-the-art in downstream processing of monoclonal antibodies: Process trends in design and validation by MARICHAL-GALLARDO, P. A, ALVAREZ, M. M

“…Monoclonal antibodies (mAbs) are the most important family of biopharmaceutical compounds in terms of market share. At present, 30 mAbs have been approved and…”
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Molecular biological characterization of an azole-resistant Candida glabrata isolate by MARICHAL, P, VANDEN BOSSCHE, H, ODDS, F. C, NOBELS, G, WARNOCK, D. W, TIMMERMAN, V, VAN BROECKHOVEN, C, FAY, S, MOSE-LARSEN, P

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Characterization of an azole-resistant Candida glabrata isolate by VANDEN BOSSCHE, H, MARICHAL, P, ODDS, F. C, LE JEUNE, L, COENE, M.-C

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Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans by BOSSCHE, H. V, MARICHAL, P, DE JEUNE, L, COENE, M.-C, GORRENS, J, COOLS, W

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Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum by WHEAT, J, MARICHAL, P, VANDEN BOSSCHE, H, LE MONTE, A, CONNOLLY, P

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Mechanisms of resistance to azole antifungals by Marichal, P, Vanden Bossche, H

“…Until the late eighties, clinical resistance to azole antifungals was a rare phenomenon. Only a few cases of resistance to ketoconazole were found in patients…”
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Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains by Maesaki, S, Marichal, P, Hossain, M A, Sanglard, D, Vanden Bossche, H, Kohno, S

“…We investigated the effects of combining tacrolimus and azole antifungal agents in azole-resistant strains of Candida albicans by comparing the accumulation of…”
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Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals by Vanden Bossche, H, Marichal, P, Gorrens, J, Bellens, D, Moereels, H, Janssen, P A

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Use of a pedicled omental flap in the treatment of an infected vascular prosthetic graft by Van Krunckelsven, L., Marichal, P., Hubens, A.

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Biochemical approaches to selective antifungal activity. Focus on azole antifungals by Vanden Bossche, H, Marichal, P, Gorrens, J, Coene, M C, Willemsens, G, Bellens, D, Roels, I, Moereels, H, Janssen, P A

“…Azole antifungals (e.g. the imidazoles: miconazole, clotrimazole, bifonazole, imazalil, ketoconazole, and the triazoles: diniconazole, triadimenol,…”
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Origin of differences in susceptibility of Candida krusei to azole antifungal agents by Marichal, P., Gorrens, J., Coene, M.-C., Jeune, L. Le, Bossche, H. Vanden

“…Two Candida krusei isolates were used to compare the effects of fluconazole, ketoconazole and itraconazole on growth and ergosterol synthesis, and to measure…”
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Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles by Van den Bossche, H, Willemsens, G, Cools, W, Marichal, P, Lauwers, W

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Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans by MARICHAL, P, KOYMANS, L, WILLEMSENS, S, BELLENS, D, VERHASSELT, P, LUYTEN, W, BORGERS, M, RAMAEKERS, F. C. S, ODDS, F. C, BOSSCHE, H. V

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Molecular mechanisms of drug resistance in fungi by Vanden Bossche, H, Marichal, P, Odds, F C

“…Failures of treatment in fungal infections have drawn attention recently to the problem of antifungal resistance and its underlying mechanisms. The number of…”
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Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains by MAESAKI, S, MARICHAL, P, VANDEN BOSSCHE, H, SANGLARD, D, KOHNO, S

“…We investigated the drug efflux mechanism in azole-resistant strains of Candida albicans using rhodamine 6G (R6G). No significant differences in R6G uptake…”
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Data reduction and representation in drug discovery by Howe, Trevor J., Mahieu, Guy, Marichal, Patrick, Tabruyn, Tom, Vugts, Pieter

“…Pre-clinical drug discovery relies increasingly on huge volumes of inter-related multivariate data. To make sense of these data and enable quality…”
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Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes by Vanden Bossche, H, Marichal, P, Willemsens, G, Bellens, D, Gorrens, J, Roels, I, Coene, M C, Le Jeune, L, Janssen, P A

“…The N-1-substituted triazole antifungal, saperconazole, is a potent inhibitor of ergosterol synthesis in Candida albicans, Aspergillus fumigatus and…”
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The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis by VANDEN BOSSCHE, Hugo, AUSMA, Jannie, BOHETS, Hilde, VERMUYTEN, Karen, WILLEMSENS, Gustaaf, MARICHAL, Patrick, MEERPOEL, Lieven, ODDS, Frank, BORGERS, Marcel

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Lipid-itraconazole interaction in lipid model membranes by Brasseur, R, Goormaghtigh, E, Ruysschaert, J M, Duquenoy, P H, Marichal, P, Vanden Bossche, H

“…Itraconazole, a lipophilic, fungal sterol-biosynthesis inhibitor, does not disturb membrane organization parameters measured by differential scanning…”
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The interaction of miconazole and ketoconazole with lipids by Van den Bossche, H, Ruysschaert, J M, Defrise-Quertain, F, Willemsens, G, Cornelissen, F, Marichal, P, Cools, W, Van Cutsem, J

“…Staphylococcus aureus can be protected by unsaturated unesterified fatty acids against the growth inhibitory effects of miconazole and ketoconazole observed at…”
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