Search Results - "Mariash, Cary N."

Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study by Pivonello, Rosario, Bancos, Irina, Feelders, Richard A, Kargi, Atil Y, Kerr, Janice M, Gordon, Murray B, Mariash, Cary N, Terzolo, Massimo, Ellison, Noel, Moraitis, Andreas G

“…Relacorilant is a selective glucocorticoid receptor modulator (SGRM) with no progesterone receptor activity. We evaluated the efficacy and safety of…”
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Corrigendum: Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study by Pivonello, Rosario, Bancos, Irina, Feelders, Richard A, Kargi, Atil Y, Kerr, Janice M, Gordon, Murray B, Mariash, Cary N, Terzolo, Massimo, Ellison, Noel, Moraitis, Andreas G

“…[This corrects the article DOI: 10.3389/fendo.2021.662865.]…”
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Overlapping Roles of the Glucose-Responsive Genes, S14 and S14R, in Hepatic Lipogenesis by Aipoalani, Derrick L, O'Callaghan, Brennon L, Mashek, Douglas G, Mariash, Cary N, Towle, Howard C

“…The Spot 14 (S14; Thrsp) gene has been implicated in supporting regulated lipogenesis in mammals. S14 gene expression in liver is controlled by a wide variety…”
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The Thrsp null mouse (Thrsp tm1cnm ) and diet-induced obesity by Anderson, Grant W., Zhu, Qihong, Metkowski, Jennifer, Stack, Mary Jo, Gopinath, Sunil, Mariash, Cary N.

“…We created a Thrsp ( Spot 14 or S14) null mouse (Thrsp tm1cnm ) to study the role of Thrsp in de novo lipid synthesis. The Thrsp null mouse exhibits marked…”
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3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent by Lei, Jianxun, Mariash, Cary N, Ingbar, David H

“…We previously reported that thyroid hormone, 3,3',5-triiodo-l-thyronine (T3), increased Na,K-ATPase activity of adult rat alveolar epithelial cells in a…”
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The Spot 14 Protein Is Required for de Novo Lipid Synthesis in the Lactating Mammary Gland by Zhu, Qihong, Anderson, Grant W, Mucha, Gregory T, Parks, Elizabeth J, Metkowski, Jennifer K, Mariash, Cary N

“…We generated a Spot 14 null mouse to assess the role of Spot 14 in de novo lipid synthesis and report the Spot 14 null mouse exhibits a phenotype in the…”
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Effect of epoprostenol on the thyroid gland: enlargement and secretion of thyroid hormone by Chadha, Chhavi, Pritzker, Marc, Mariash, Cary N

“…To demonstrate the direct stimulation of thyroid tissue in the absence of thyroid-stimulating immunoglobulin after exposure to epoprostenol. Seronegative…”
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Thyroid Hormone Regulates Oligodendrocyte Accumulation in Developing Rat Brain White Matter Tracts by Schoonover, Christopher M, Seibel, Melissa M, Jolson, Dawn M, Stack, Mary Jo, Rahman, Rounak J, Jones, Sidney A, Mariash, Cary N, Anderson, Grant W

“…Thyroid hormone (TH) is necessary for normal axonal myelination. Myelin basic protein (MBP) is a structural protein essential for myelin function. In this…”
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Dose-dependent relationship between levothyroxine and health-related quality of life in survivors of differentiated thyroid cancer by Braafladt, Signe, Allison, Hannah, Chung, Jeanette, Mariash, Cary N., Bhattacharyya, Oindrila, McDow, Alexandria D., Haggstrom, David A.

“…Long-term survival for patients with differentiated (papillary, follicular, and Hürthle cell) thyroid cancer exceeds 95% but self-reported health-related…”
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Hepatic Expression of the SPOT 14 (S14) Paralog S14-Related (Mid1 Interacting Protein) Is Regulated by Dietary Carbohydrate by Tsatsos, Nikolas G, Augustin, Lance B, Anderson, Grant W, Towle, Howard C, Mariash, Cary N

“…The Spot 14 (S14) gene is rapidly up-regulated by signals that induce lipogenesis such as enhanced glucose metabolism and thyroid hormone administration…”
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Thyroid hormone stimulates Na-K-ATPase activity and its plasma membrane insertion in rat alveolar epithelial cells by Lei, Jianxun, Nowbar, Sogol, Mariash, Cary N, Ingbar, David H

“…Na-K-ATPase protein is critical for maintaining cellular ion gradients and volume and for transepithelial ion transport in kidney and lung. Thyroid hormone,…”
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Profound Hypoglycemia and Corresponding Insulin Levels with Massive Glargine Overdose by SAEED, ZEB I., ZIA, ZAHRA, MARIASH, CARY N.

“…Introduction: Despite widespread use of insulin in diabetes, reports of intentional overdose are rare. Insulin kinetics are different in acute poisoning from…”
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Hyperthyroidism in Pregnancy and Lactation: A Different Paradigm? by Rind, Jubran, Mariash, Cary N

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Outcomes of Preoperative Medical Therapy for Thyroidectomy in Autoimmune Thyroid Disease by Braafladt, Signe M., Baumgartner, Timothy C., Allison, Hannah R., Blumenthaler, Alisa N., Ritter, Hadley E., Mariash, Cary N., Elfenbein, Dawn M., McDow, Alexandria D.

“…Thyroidectomy provides definitive treatment for autoimmune thyroid disease (AITD) often resulting in improved quality of life. Historically, patients with AITD…”
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Development of an objective tool for the diagnosis of myxedema coma by Chiong, Yien V, Bammerlin, Elaine, Mariash, Cary N

“…Myxedema coma, a rare entity, with a reported 25%–65% mortality had no objective criteria for making the diagnosis when we began our study. We developed an…”
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Relacorilant, a Selective Glucocorticoid Receptor Modulator in Development for the Treatment of Patients With Cushing Syndrome, Does Not Cause Prolongation of the Cardiac QT Interval by Donegan, Diane M, Pivonello, Rosario, Stigliano, Antonio, Lardo, Pina, Kearney, Tara, Mezősi, Emese, Ghigo, Ezio, Giordano, Roberta, Mariash, Cary N, Feelders, Richard A, Donaldson, Kirsteen, Darpo, Borje, Xue, Hongqi, Custodio, Joseph M, Hand, Austin L, Moraitis, Andreas G

“…To assess the effect of relacorilant, a selective glucocorticoid receptor modulator under investigation for the treatment of patients with endogenous…”
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Human Spot 14 Glucose and Thyroid Hormone Response: Characterization and Thyroid Hormone Response Element Identification by Campbell, Mark C, Anderson, Grant W, Mariash, Cary N

“…Spot 14 is a 17-kDa protein expressed in lipogenic tissues and is postulated to play a role in thyroid hormone stimulation of lipogenesis. To further our…”
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Teprotumumab and Hyperglycemia Guidelines to Monitor for Hyperglycemia in Teprotumumab by Lee, H. B. Harold, Mariash, Cary N., Yoon, Michael K., Belinsky, Irina, Creighton, Francis X., Mahoney, Nicholas, Petris, Carisa K., Callahan, Alison B., Campbell, Ashley A., Kazim, Michael, Dagi Glass, Lora R.

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Temporal occurrences and recurrence patterns of hypoglycemia during hospitalization by Ulmer, Brian J, Kara, Areeba, Mariash, Cary N

“…To describe the temporal distribution of hypoglycemia and its rate of recurrence during hospitalization to aid in the development of strategies to prevent…”
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Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs? by Shoemaker, Timothy J, Kono, Tatsuyoshi, Mariash, Cary N, Evans-Molina, Carmella

“…To provide a comprehensive review of the discovery and development of selective thyroid hormone receptor agonists and provide a discussion of their use in…”
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