Search Results - "Mariappan, Malaiyalam"

Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins by Culver, Jacob A, Mariappan, Malaiyalam

“…Numerous proteins that have hydrophobic transmembrane domains (TMDs) traverse the cytosol and posttranslationally insert into cellular membranes. It is unclear…”
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The Sec61 translocon limits IRE1α signaling during the unfolded protein response by Sundaram, Arunkumar, Plumb, Rachel, Appathurai, Suhila, Mariappan, Malaiyalam

“…IRE1α is an endoplasmic reticulum (ER) localized endonuclease activated by misfolded proteins in the ER. Previously, we demonstrated that IRE1α forms a complex…”
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A functional link between the co-translational protein translocation pathway and the UPR by Plumb, Rachel, Zhang, Zai-Rong, Appathurai, Suhila, Mariappan, Malaiyalam

“…Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is…”
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A ribosome-associating factor chaperones tail-anchored membrane proteins by Hegde, Ramanujan S, Mariappan, Malaiyalam, Li, Xingzhe, Stefanovic, Sandra, Sharma, Ajay, Mateja, Agnieszka, Keenan, Robert J

“…Hundreds of proteins are inserted post-translationally into the endoplasmic reticulum (ER) membrane by a single carboxy-terminal transmembrane domain (TMD)…”
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The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER by Heo, Paul, Culver, Jacob A., Miao, Jennifer, Pincet, Frederic, Mariappan, Malaiyalam

“…Tail-anchored (TA) proteins contain a single C-terminal transmembrane domain (TMD) that is captured by the cytosolic Get3 in yeast (TRC40 in humans). Get3…”
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The mechanism of membrane-associated steps in tail-anchored protein insertion by Mariappan, Malaiyalam, Mateja, Agnieszka, Dobosz, Malgorzata, Bove, Elia, Hegde, Ramanujan S., Keenan, Robert J.

“…Tail-anchored (TA) membrane proteins destined for the endoplasmic reticulum are chaperoned by cytosolic targeting factors that deliver them to a membrane…”
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The structural basis of tail-anchored membrane protein recognition by Get3 by Mateja, Agnieszka, Szlachcic, Anna, Downing, Maureen E., Dobosz, Malgorzata, Mariappan, Malaiyalam, Hegde, Ramanujan S., Keenan, Robert J.

“…Targeting of newly synthesized membrane proteins to the endoplasmic reticulum is an essential cellular process. Most membrane proteins are recognized and…”
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Molecular Basis for Multiple Sulfatase Deficiency and Mechanism for Formylglycine Generation of the Human Formylglycine-Generating Enzyme by Dierks, Thomas, Dickmanns, Achim, Preusser-Kunze, Andrea, Schmidt, Bernhard, Mariappan, Malaiyalam, von Figura, Kurt, Ficner, Ralf, Rudolph, Markus Georg

“…Sulfatases are enzymes essential for degradation and remodeling of sulfate esters. Formylglycine (FGly), the key catalytic residue in the active site, is…”
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ERp44 Mediates a Thiol-independent Retention of Formylglycine-generating Enzyme in the Endoplasmic Reticulum by Mariappan, Malaiyalam, Radhakrishnan, Karthikeyan, Dierks, Thomas, Schmidt, Bernhard, von Figura, Kurt

“…Inside the endoplasmic reticulum (ER) formylglycine-generating enzyme (FGE) catalyzes in newly synthesized sulfatases the post-translational oxidation of a…”
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C-terminal tail length guides insertion and assembly of membrane proteins by Sun, Sha, Mariappan, Malaiyalam

“…A large number of newly synthesized membrane proteins in the endoplasmic reticulum (ER) are assembled into multiprotein complexes, but little is known about…”
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The Non-catalytic N-terminal Extension of Formylglycine-generating Enzyme Is Required for Its Biological Activity and Retention in the Endoplasmic Reticulum by Mariappan, Malaiyalam, Gande, Santosh Lakshmi, Radhakrishnan, Karthikeyan, Schmidt, Bernhard, Dierks, Thomas, von Figura, Kurt

“…Formylglycine-generating enzyme (FGE) catalyzes the oxidation of a specific cysteine residue in nascent sulfatase polypeptides to formylglycine (FGly). This…”
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Lonely ER Membrane Proteins Travel to the Nucleus to Rest in Peace by the Asi Complex by Sun, Sha, Mariappan, Malaiyalam

“…In a recent issue of Molecular Cell, Natarajan et al. (2020) showed that unassembled ER membrane proteins diffuse to the INM for degradation. The INM-localized…”
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Paralog of the formylglycine‐generating enzyme – retention in the endoplasmic reticulum by canonical and noncanonical signals by Gande, Santosh Lakshmi, Mariappan, Malaiyalam, Schmidt, Bernhard, Pringle, Thomas H., von Figura, Kurt, Dierks, Thomas

“…Formylglycine‐generating enzyme (FGE) catalyzes in newly synthesized sulfatases the oxidation of a specific cysteine residue to formylglycine, which is the…”
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Signal sequences encode information for protein folding in the endoplasmic reticulum by Sun, Sha, Li, Xia, Mariappan, Malaiyalam

“…One-third of newly synthesized proteins in mammals are translocated into the endoplasmic reticulum (ER) through the Sec61 translocon. How protein translocation…”
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Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress by Sundaram, Arunkumar, Appathurai, Suhila, Plumb, Rachel, Mariappan, Malaiyalam

“…The endoplasmic reticulum (ER) localized unfolded protein response (UPR) sensors, IRE1α, PERK, and ATF6α, are activated by the accumulation of misfolded…”
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Deciphering the molecular organization of GET pathway chaperones through native mass spectrometry by Giska, Fabian, Mariappan, Malaiyalam, Bhattacharyya, Moitrayee, Gupta, Kallol

“…Get3/4/5 chaperone complex is responsible for targeting C-terminal tail-anchored membrane proteins to the endoplasmic reticulum. Despite the availability of…”
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Deciphering the molecular organization of Get pathway chaperones through native top-down dissociation of multi-protein complexes by Giska, Fabian, Mariappan, Malaiyalam, Bhattacharyya, Moitrayee, Gupta, Kallol

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A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress by Li, Xia, Sun, Sha, Appathurai, Suhila, Sundaram, Arunkumar, Plumb, Rachel, Mariappan, Malaiyalam

“…Misfolded proteins in the endoplasmic reticulum (ER) activate IRE1α endoribonuclease in mammalian cells, which mediates XBP1 mRNA splicing to produce an active…”
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Membrane Protein Biogenesis: PAT Complex Pats Membrane Proteins into Shape by Culver, Jacob A., Mariappan, Malaiyalam

“…Membrane proteins with multiple transmembrane domains play essential roles in the cell, but little is known about the machinery involved in the assembly of…”
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Protein targeting and degradation are coupled for elimination of mislocalized proteins by Hessa, Tara, Sharma, Ajay, Mariappan, Malaiyalam, Eshleman, Heather D., Gutierrez, Erik, Hegde, Ramanujan S.

“…Removal of 'spare' proteins Membrane proteins that fail to be delivered to the endoplasmic reticulum must be rapidly degraded to avoid inappropriate…”
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