Search Results - "Mariano, Jennifer"

ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20 by Portney, Benjamin A., Khatri, Raju, Meltzer, W. Alex, Mariano, Jennifer M., Zalzman, Michal

“…Zscan4 is an early embryonic gene cluster expressed in mouse embryonic stem and induced pluripotent stem cells where it plays critical roles in genomic…”
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The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation by Zhou, Ming, Weissman, Allan M, Hewitt, Stephen M, Helman, Lee J, Mendoza, Arnulfo, Khanna, Chand, Tsai, Yien Che, Chen, Bo, Kostova, Zlatka, Veenstra, Timothy, Mariano, Jennifer M

“…Metastasis is the primary cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. In particular, relatively little is…”
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A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms by Metzger, Meredith B., Liang, Yu-He, Das, Ranabir, Mariano, Jennifer, Li, Shengjian, Li, Jess, Kostova, Zlatka, Byrd, R. Andrew, Ji, Xinhua, Weissman, Allan M.

“…Cue1p is an integral component of yeast endoplasmic reticulum (ER)-associated degradation (ERAD) ubiquitin ligase (E3) complexes. It tethers the ERAD…”
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Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78 by Das, Ranabir, Mariano, Jennifer, Tsai, Yien Che, Kalathur, Ravi C., Kostova, Zlatka, Li, Jess, Tarasov, Sergey G., McFeeters, Robert L., Altieri, Amanda S., Ji, Xinhua, Byrd, R. Andrew, Weissman, Allan M.

“…The activity of RING finger ubiquitin ligases (E3) is dependent on their ability to facilitate transfer of ubiquitin from ubiquitin-conjugating enzymes (E2) to…”
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The Activity of a Human Endoplasmic Reticulum-Associated Degradation E3, gp78, Requires Its Cue Domain, RING Finger, and an E2-Binding Site by Chen, Bo, Mariano, Jennifer, Tsai, Yien Che, Chan, Anna H., Cohen, Mickael, Weissman, Allan M.

“…Efficient targeting of proteins for degradation from the secretory pathway is essential to homeostasis. This occurs through endoplasmic reticulum…”
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NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy by Ranu, Natasha, Laitila, Jenni, Dugdale, Hannah F, Mariano, Jennifer, Kolb, Justin S, Wallgren-Pettersson, Carina, Witting, Nanna, Vissing, John, Vilchez, Juan Jesus, Fiorillo, Chiara, Zanoteli, Edmar, Auranen, Mari, Jokela, Manu, Tasca, Giorgio, Claeys, Kristl G, Voermans, Nicol C, Palmio, Johanna, Huovinen, Sanna, Moggio, Maurizio, Beck, Thomas Nyegaard, Kontrogianni-Konstantopoulos, Aikaterini, Granzier, Henk, Ochala, Julien

“…Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle disorders. NM is often associated with mutations in the NEB gene. Even though…”
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Ubc7p-binding domain in Cue1p activates ER-associated protein degradation by Kostova, Zlatka, Mariano, Jennifer, Scholz, Simone, Koenig, Carolin, Weissman, Allan M

“…Cue1p is an N-terminally anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s)…”
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WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation by Magnifico, Alessandra, Ettenberg, Seth, Yang, Cuihong, Mariano, Jennifer, Tiwari, Swati, Fang, Shengyun, Lipkowitz, Stan, Weissman, Allan M.

“…Cbl proteins have RING finger-dependent ubiquitin ligase (E3) activity that is essential for down-regulation of tyrosine kinases. Here we establish that two WW…”
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Coordinate Expression of Transforming Growth Factor-β1 and Adrenomedullin in Rodent Embryogenesis by Montuenga, Luis M, Mariano, Jennifer M, Prentice, Margaret A, Cuttitta, Frank, Jakowlew, Sonia B

“…Transforming growth factor-β (TGFβ) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant…”
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Compound heterozygous variants in MYBPC1 lead to severe distal arthrogryposis type-1 manifestations by Iyer, Aishwarya, Lauerova, Barbora, Mariano, Jennifer, Haberlová, Jana, Lassuthova, Petra, Zidkova, Jana, Wright, Nathan T., Kontrogianni-Konstantopoulos, Aikaterini

“…•MYBPC1 is an emerging myopathic gene associated with severe and lethal forms of arthrogryposis multiplex congenita syndromes.•Two novel compound heterozygous…”
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SARS-CoV-2 papain-like protease plays multiple roles in regulating cellular proteins in the endoplasmic reticulum by Yang, Mei, Mariano, Jennifer, Su, Rebecca, Smith, Christopher E., Das, Sudipto, Gill, Catherine, Andresson, Thorkell, Loncarek, Jadranka, Tsai, Yien Che, Weissman, Allan M.

“…Nsp3s are the largest nonstructural proteins of coronaviruses. These transmembrane proteins include papain-like proteases (PLpro) that play essential roles in…”
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COPD C.A.R.E. Connect: A Systems Trajectory to Reducing COPD Readmissions in a Large National Healthcare Institution by Mariano, Jennifer M

“…COPD is the third principal diagnosis accounting for 30-day all-cause readmission, 14.4% of rehospitalization are due to acute exacerbation and occur within 3…”
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Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine by Das, Ranabir, Liang, Yu-He, Mariano, Jennifer, Li, Jess, Huang, Tao, King, Aaren, Tarasov, Sergey G, Weissman, Allan M, Ji, Xinhua, Byrd, R Andrew

“…RING finger proteins constitute the large majority of ubiquitin ligases (E3s) and function by interacting with ubiquitin‐conjugating enzymes (E2s) charged with…”
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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation by Smith, Christopher E, Tsai, Yien Che, Liang, Yu-He, Khago, Domarin, Mariano, Jennifer, Li, Jess, Tarasov, Sergey G, Gergel, Emma, Tsai, Borong, Villaneuva, Matthew, Clapp, Michelle E, Magidson, Valentin, Chari, Raj, Byrd, R Andrew, Ji, Xinhua, Weissman, Allan M

“…Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple…”
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Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B by Li, Shengjian, Liang, Yu-He, Mariano, Jennifer, Metzger, Meredith B., Stringer, Daniel K., Hristova, Ventzislava A., Li, Jess, Randazzo, Paul A., Tsai, Yien Che, Ji, Xinhua, Weissman, Allan M.

“…RING proteins constitute the largest class of E3 ubiquitin ligases. Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjugating enzyme, UbcH5B (UBE2D2),…”
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Human pulmonary acinar aplasia : Reduction of transforming growth factor-β ligands and receptors by CHEN, M.-F, GRAY, K. D, PRENTICE, M. A, MARIANO, J. M, JAKOWLEW, S. B

“…Pulmonary hypoplasia has been found in the human neonatal autopsy population and has been attributed to an alteration in epithelial-mesenchymal interactions…”
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Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells by Jakowlew, Sonia B, Mariano, Jennifer M, You, Liang, Mathias, Askale

“…In addition to autoregulating its own expression, transforming growth factor-beta 1 (TGF- β1) also regulates the production of proteases, protease inhibitors…”
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Teachers' Understanding of the Effects of Japanese Culture on Social Play with Young Children by Mariano, Jennifer A, Welteroth, Susan J, Johnson, James E

“…Used ethnographic techniques to examine the knowledge of American teachers who had taught young Japanese children, regarding the role of culture in Japanese…”
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Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency by Tang, Binwu, Böttinger, Erwin P, Jakowlew, Sonia B, Bagnall, Kerri M, Mariano, Jennifer, Anver, Miriam R, Letterio, John J, Wakefield, Lalage M

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Nkx2.1 transcription factor in lung cells and a transforming growth factor-β1 heterozygous mouse model of lung carcinogenesis by Kang, Yang, Hebron, Haroun, Ozbun, Laurent, Mariano, Jennifer, Minoo, Parviz, Jakowlew, Sonia B.

“…The Nkx2.1 homeobox gene and transforming growth factor‐β1 (TGF‐β1) are essential for organogenesis and differentiation of the mouse lung. NKX2.1 is a marker…”
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