Search Results - "Mariani, Samanta A"

Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation by Petruk, Svetlana, Cai, Jingli, Sussman, Robyn, Sun, Guizhi, Kovermann, Sina K., Mariani, Samanta A., Calabretta, Bruno, McMahon, Steven B., Brock, Hugh W., Iacovitti, Lorraine, Mazo, Alexander

“…Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation…”
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In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate by Eich, Christina, Arlt, Jochen, Vink, Chris S, Solaimani Kartalaei, Parham, Kaimakis, Polynikis, Mariani, Samanta A, van der Linden, Reinier, van Cappellen, Wiggert A, Dzierzak, Elaine

“…Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play…”
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Embryonic Origins of the Hematopoietic System: Hierarchies and Heterogeneity by Vink, Chris S., Mariani, Samanta A., Dzierzak, Elaine

“…The hierarchical framework of the adult blood system as we know it from current medical and hematology textbooks, displays a linear branching network of…”
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Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification by Petruk, Svetlana, Mariani, Samanta A., De Dominici, Marco, Porazzi, Patrizia, Minieri, Valentina, Cai, Jingli, Iacovitti, Lorraine, Flomenberg, Neal, Calabretta, Bruno, Mazo, Alexander

“…The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs…”
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E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates by Wanet, Anaïs, Bassal, Mahmoud A, Patel, Sweta B, Marchi, Francisco, Mariani, Samanta A, Ahmed, Nouraiz, Zhang, Haoran, Borchiellini, Marta, Chen, Sisi, Zhang, Junyan, Di Ruscio, Annalisa, Miyake, Kensuke, Tsai, Mindy, Paranjape, Anuya, Park, Shin-Young, Karasuyama, Hajime, Schroeder, Timm, Dzierzak, Elaine, Galli, Stephen J, Tenen, Daniel G, Welner, Robert S

“…E-cadherin is a calcium-dependent cell-cell adhesion molecule extensively studied for its involvement in tissue formation, epithelial cell behavior, and…”
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Asymmetric HIV-1 co-receptor use and replication in CD4(+) T lymphocytes by Mariani, Samanta A, Vicenzi, Elisa, Poli, Guido

“…Susceptibility to infection by the human immunodeficiency virus type-1 (HIV-1), both in vitro and in vivo, requires the interaction between its envelope (Env)…”
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From drosophila to humans: a journey through macrophage development by Doyle, Eva H., Vaughan, Hollie J., Mariani, Samanta A.

“…•Macrophages are complex cells with multiple roles in both embryos and adults.•Macrophage development is spatio-temporally regulated across different…”
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Jeff Pollard (1950–2023) by Coussens, Lisa M., De Palma, Michele, Mariani, Samanta A., Cassetta, Luca

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Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility by Pecorari, Luisa, Marin, Oriano, Silvestri, Chiara, Candini, Olivia, Rossi, Elena, Guerzoni, Clara, Cattelani, Sara, Mariani, Samanta A, Corradini, Francesca, Ferrari-Amorotti, Giovanna, Cortesi, Laura, Bussolari, Rita, Raschellà, Giuseppe, Federico, Massimo R, Calabretta, Bruno

“…Akt/PKB is a serine/threonine kinase that has attracted much attention because of its central role in regulating cell proliferation, survival, motility and…”
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Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head by Li, Zhuan, Vink, Chris S., Mariani, Samanta A., Dzierzak, Elaine

“…Hematopoietic cell generation in the midgestation mouse embryo occurs through the natural transdifferentiation of temporally and spatially restricted set of…”
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CNS macrophages differentially rely on an intronic Csf1r enhancer for their development by Munro, David A D, Bradford, Barry M, Mariani, Samanta A, Hampton, David W, Vink, Chris S, Chandran, Siddharthan, Hume, David A, Pridans, Clare, Priller, Josef

“…The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated…”
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Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation by Porcheri, Cristina, Golan, Ohad, Calero‐Nieto, Fernando J, Thambyrajah, Roshana, Ruiz‐Herguido, Cristina, Wang, Xiaonan, Catto, Francesca, Guillén, Yolanda, Sinha, Roshani, González, Jessica, Kinston, Sarah J, Mariani, Samanta A, Maglitto, Antonio, Vink, Chris S, Dzierzak, Elaine, Charbord, Pierre, Göttgens, Bertie, Espinosa, Lluis, Sprinzak, David, Bigas, Anna

“…Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is…”
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A role for macrophages in hematopoiesis in the embryonic head by Li, Zhuan, Mariani, Samanta A., Rodriguez-Seoane, Carmen, He, Wenyan, Ning, Xiaowei, Liu, Bing, Vink, Chris S., Dzierzak, Elaine

“…Along with the aorta-gonad-mesonephros region, the head is a site of hematopoietic stem and progenitor cell (HS/PC) development in the mouse embryo…”
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Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia by Minieri, Valentina, De Dominici, Marco, Porazzi, Patrizia, Mariani, Samanta A, Spinelli, Orietta, Rambaldi, Alessandro, Peterson, Luke F, Porcu, Pierluigi, Nevalainen, Marja T, Calabretta, Bruno

“…Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with…”
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Leukemia stem cells: Old concepts and new perspectives by Mariani, Samanta A., Calabretta, Bruno

“…Myeloid leukemias are heterogeneous malignancies in morphology, immunophenotype, genetic and epigenetic alterations, and response to therapy. This…”
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Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph + Acute Lymphoblastic Leukemia by De Dominici, Marco, Porazzi, Patrizia, Soliera, Angela Rachele, Mariani, Samanta A, Addya, Sankar, Fortina, Paolo, Peterson, Luke F, Spinelli, Orietta, Rambaldi, Alessandro, Martinelli, Giovanni, Ferrari, Anna, Iacobucci, Ilaria, Calabretta, Bruno

“…Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with…”
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Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia by Liao, Zhiyong, Gu, Lei, Vergalli, Jenny, Mariani, Samanta A, De Dominici, Marco, Lokareddy, Ravi K, Dagvadorj, Ayush, Purushottamachar, Puranik, McCue, Peter A, Trabulsi, Edouard, Lallas, Costas D, Gupta, Shilpa, Ellsworth, Elyse, Blackmon, Shauna, Ertel, Adam, Fortina, Paolo, Leiby, Benjamin, Xia, Guanjun, Rui, Hallgeir, Hoang, David T, Gomella, Leonard G, Cingolani, Gino, Njar, Vincent, Pattabiraman, Nagarajan, Calabretta, Bruno, Nevalainen, Marja T

“…Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we…”
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Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2 by Riva, Beatrice, De Dominici, Marco, Gnemmi, Ilaria, Mariani, Samanta A, Minassi, Alberto, Minieri, Valentina, Salomoni, Paolo, Canonico, Pier Luigi, Genazzani, Armando A, Calabretta, Bruno, Condorelli, Fabrizio

“…CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and…”
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Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation by Maglitto, Antonio, Mariani, Samanta A., de Pater, Emma, Rodriguez-Seoane, Carmen, Vink, Chris S., Piao, Xianhua, Lukke, Mari-Liis, Dzierzak, Elaine

“…Integrated molecular signals regulate cell fate decisions in the embryonic aortic endothelium to drive hematopoietic stem cell (HSC) generation during…”
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Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells by Guerzoni, Clara, Bardini, Michela, Mariani, Samanta A., Ferrari-Amorotti, Giovanna, Neviani, Paolo, Panno, Maria Luisa, Zhang, Ying, Martinez, Robert, Perrotti, Danilo, Calabretta, Bruno

“…Translational regulation by oncogenic proteins may be a rapid and efficient mechanism to modulate gene expression. We report here the identification of the…”
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