Search Results - "Maria Ravena Severino Carvalho, Ana"
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Immunogenomic screening approach to identify new antigens for the serological diagnosis of chronic Chagas’ disease
Published in Applied microbiology and biotechnology (01-07-2018)“…Serological tests are preferentially used for the diagnosis of Chagas’ disease (CD) during the chronic phase because of the low parasitemia and high anti-…”
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New antigens for the serological diagnosis of human visceral leishmaniasis identified by immunogenomic screening
Published in PloS one (20-12-2018)“…Visceral leishmaniasis (VL) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed, that…”
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Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis
Published in Applied microbiology and biotechnology (01-09-2021)“…Leishmania braziliensis is responsible for most cases of human tegumentary leishmaniasis (HTL) and has caused a wide range of clinical manifestations,…”
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Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containing polymeric micelle system
Published in Parasitology international (01-12-2016)“…Abstract New therapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact that drug discovery is a long and expensive process, the…”
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An 8-hydroxyquinoline-containing polymeric micelle system is effective for the treatment of murine tegumentary leishmaniasis
Published in Parasitology research (1987) (01-11-2016)“…The current treatment of leishmaniasis has been hampered due to the high toxicity of the available drugs and long duration protocols, which often lead to its…”
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Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Published in European journal of pharmaceutics and biopharmaceutics (01-06-2024)“…[Display omitted] •A treatment that used the topical route as an alternative to treatment for tegumentary leishmaniasis.•8-hydroxyquinoline (8-HQN) was…”
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CD4+ and CD8+ T-cell multi-epitope chimeric protein associated with an MPLA adjuvant induce protective efficacy and long-term immunological memory for the immunoprophylaxis of American Tegumentary Leishmaniasis
Published in Vaccine (30-08-2024)“…American Tegumentary Leishmaniasis (ATL) is a disease of high severity and incidence in Brazil, in addition to being a worldwide concern in public health…”
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Development of an immunogen containing CD4+/CD8+ T-cell epitopes for the prophylaxis of tegumentary leishmaniasis
Published in Applied microbiology and biotechnology (01-06-2022)“…Tegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological agent. The…”
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Mapping linear B-cell epitopes of the Tryparedoxin Peroxidase and its implications in the serological diagnosis of tegumentary leishmaniasis
Published in Acta tropica (01-08-2022)“…•Tryparedoxin Peroxidase for the diagnosis of tegumentary leishmaniasis.•Integration between immunoproteomic and immunoinformatics analysis.•Flow cytometry…”
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Chagas cardiomyopathy is associated with a high susceptibility to T. cruzi infection in monocyte-derived macrophages and a predominance of CD4+CD45RO+ T-cells with immunoregulatory patterns
Published in Acta tropica (01-01-2023)“…•Immunopathogenesis of chronic chagas cardiomyopathy.•Monocytes from CCC patients present high susceptibility to infection.•High IL-10 and low IFN-γ and…”
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A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection
Published in Immunobiology (1979) (01-02-2017)“…Graphical abstract…”
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Performance of Leishmania braziliensis enolase protein for the serodiagnosis of canine and human visceral leishmaniosis
Published in Veterinary parasitology (30-04-2017)“…[Display omitted] •Enolase protein was cloned from L. braziliensis species.•It was found conserved between the L. braziliensis and L. infantum species.•An…”
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Development of an immunogen containing CD4.sup.+/CD8.sup.+ T-cell epitopes for the prophylaxis of tegumentary leishmaniasis
Published in Applied microbiology and biotechnology (01-06-2022)“…Tegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological agent. The…”
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Immunoproteomics approach for the discovery of antigens applied to the diagnosis of canine visceral leishmaniasis
Published in Acta tropica (01-05-2023)“…•Rational strategy to identify proteins of L. infantum by immunoproteomic approach.•Proteomic map of L. infantum parasites isolated from asymptomatic and…”
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