Search Results - "Maria Eugênia da Costa"
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In-Vitro and In-Vivo Establishment and Characterization of Bioluminescent Orthotopic Chemotherapy-Resistant Human Osteosarcoma Models in NSG Mice
Published in Cancers (17-07-2019)“…Osteosarcoma, the most common bone malignancy with a peak incidence at adolescence, had no survival improvement since decades. Persistent problems are…”
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Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models
Published in Clinical cancer research (03-04-2023)“…ALK-activating mutations are identified in approximately 10% of newly diagnosed neuroblastomas and ALK amplifications in a further 1%-2% of cases. Lorlatinib,…”
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3
MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma
Published in Scientific reports (23-08-2019)“…Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. Resistance to chemotherapy remains a key challenge for effective…”
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4
Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers
Published in Frontiers in immunology (22-01-2024)“…The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric…”
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5
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Published in Communications biology (18-09-2023)“…Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models…”
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6
Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis
Published in Cancer research (Chicago, Ill.) (15-03-2022)“…The outcomes of adolescents/young adults with osteosarcoma have not improved in decades. The chaotic karyotype of this rare tumor has precluded the…”
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7
From biology to personalized medicine: Recent knowledge in osteosarcoma
Published in European journal of medical genetics (01-06-2024)“…High-grade osteosarcoma is the most common paediatric bone cancer. More than one third of patients relapse and die of osteosarcoma using current…”
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8
Fibra de cultivares de algodoeiro sob condições de sequeiro
Published in Revista verde de agroecologia e desenvolvimento sustentável (01-01-2019)“…Objetivando avalizar as características de fibra do diferentes cultivares de algodão realizou-se uma pesquisa Campo Experimental da Fazenda Escola da Faculdade…”
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9
Massa seca e teores de nutrientes de plantas de milho sob efeito de águas salinas e biochar
Published in Revista verde de agroecologia e desenvolvimento sustentável (01-12-2018)“…O milho é cultivado em todo o Brasil para uso na alimentação humana e animal e como matéria prima de biocombustíveis e indústria. Sua produtividade é…”
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10
Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation
Published in BMC cancer (20-07-2021)“…Background Epithelioid sarcomas and rhabdoid tumors are rare, aggressive malignancies with poor prognosis. Both are characterized by INI1 alterations and…”
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11
CellsFromSpace: a fast, accurate, and reference-free tool to deconvolve and annotate spatially distributed omics data
Published in Bioinformatics advances (2024)“…Spatial transcriptomics enables the analysis of cell crosstalk in healthy and diseased organs by capturing the transcriptomic profiles of millions of cells…”
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12
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
Published in Cell reports. Medicine (18-06-2024)“…Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma driven by the EWSR1::WT1 chimeric transcription factor. Despite this unique oncogenic…”
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13
Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models
Published in Frontiers in oncology (12-06-2023)“…Osteosarcoma is a rare bone cancer in adolescents and young adults with a dismal prognosis because of metastatic disease and chemoresistance. Despite multiple…”
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14
Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice
Published in Cancer medicine (Malden, MA) (01-03-2018)“…Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the…”
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15
AIF-CHCHD4 dependent metabolic plasticity in pediatric cancer
Published in Biochimica et biophysica acta. Molecular basis of disease (01-12-2024)Get full text
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Recent advances in understanding osteosarcoma and emerging therapies
Published in Faculty reviews (2020)“…Osteosarcoma is the most common bone cancer in adolescents and young adults, but it is a rare cancer with no improvement in patient survival in the last four…”
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Unlocking the potential of molecular-driven stratification for osteosarcoma treatment and prognosis
Published in Oncotarget (11-02-2023)Get full text
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18
Estratégias de irrigação com água salina na mamoneira
Published in Ciência agronômica (01-03-2013)Get full text
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Estratégias de irrigação com água salina na mamoneira Irrigation strategies with saline water in castor oil plant
Published in Ciência agronômica (01-03-2013)“…Este experimento foi realizado em campo para avaliar estratégias de irrigação com água salina no crescimento e na produção da mamoneira (BRS Energia), além de…”
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Population mobility and production of American tegumentary leishmaniasis in the State of Paraná, southern Brazil
Published in Revista da Sociedade Brasileira de Medicina Tropical (01-09-2009)“…Information on the role of population mobility in maintaining American tegumentary leishmaniasis in the State of Paraná is scarce. Population mobility was…”
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