Search Results - "Maria Borrello"

Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib by Fraunhoffer, Nicolas A, Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Telle, Emmanuel, Santofimia-Castaño, Patricia, Borrello, María Teresa, Chuluyan, Eduardo, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate less than 5%. Multiple chemotherapeutic drugs have been tested to improve…”
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Per una giustizia sostenibile by Borrello, Maria

“…RiassuntoIl presente contributo si propone di analizzare la relazione tra sostenibilità e giustizia, al fine di metterne in evidenza il carattere riflessivo…”
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The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies by Muzza, Marina, Degl'Innocenti, Debora, Colombo, Carla, Perrino, Michela, Ravasi, Elena, Rossi, Stefania, Cirello, Valentina, Beck-Peccoz, Paolo, Borrello, Maria Grazia, Fugazzola, Laura

“…Summary Objective  The recent concept that oncogenes responsible for thyroid neoplastic transformation are able to elicit an inflammatory protumourigenic…”
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'Palaeoshellomics' reveals the use of freshwater mother-of-pearl in prehistory by Sakalauskaite, Jorune, Andersen, Søren H, Biagi, Paolo, Borrello, Maria A, Cocquerez, Théophile, Colonese, André Carlo, Dal Bello, Federica, Girod, Alberto, Heumüller, Marion, Koon, Hannah, Mandili, Giorgia, Medana, Claudio, Penkman, Kirsty Eh, Plasseraud, Laurent, Schlichtherle, Helmut, Taylor, Sheila, Tokarski, Caroline, Thomas, Jérôme, Wilson, Julie, Marin, Frédéric, Demarchi, Beatrice

“…The extensive use of mollusc shell as a versatile raw material is testament to its importance in prehistoric times. The consistent choice of certain species…”
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NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response by Teresa Borrello, Maria, Rita Emma, Maria, Listi, Angela, Rubis, Marion, Coslet, Sergiu, Augello, Giuseppa, Cusimano, Antonella, Cabibi, Daniela, Porcasi, Rossana, Giannitrapani, Lydia, Soresi, Maurizio, Pantuso, Gianni, Blyth, Karen, Montalto, Giuseppe, Pin, Christopher, Cervello, Melchiorre, Iovanna, Juan

“…Non‐alcoholic fatty liver (NAFL) and related syndromes affect one‐third of the adult population in industrialized and developing countries. Lifestyle and…”
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Development and Validation of a Self-Determination Theory-Based Measure of Motivation to Exercise and Diet in Children by Pietrabissa, Giada, Rossi, Alessandro, Borrello, Maria, Manzoni, Gian Mauro, Mannarini, Stefania, Castelnuovo, Gianluca, Molinari, Enrico

“…Objective: To develop and test the factorial structure of a new self-determination theory–based measure of behavioral regulation in children. Methods: Five…”
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Synthesis of Carboxamide‐Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia by Teresa Borrello, Maria, Benelkebir, Hanae, Lee, Adam, Hin Tam, Chak, Shafat, Manar, Rushworth, Stuart A., Bowles, Kristian M., Douglas, Leon, Duriez, Patrick J., Bailey, Sarah, Crabb, Simon J., Packham, Graham, Ganesan, A.

“…Lysine‐specific demethylase 1 (LSD1/KDM1A) oxidatively removes methyl groups from histone proteins, and its aberrant activity has been correlated with cancers…”
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Pathways connecting inflammation and cancer by Allavena, Paola, Garlanda, Cecilia, Borrello, Maria Grazia, Sica, Antonio, Mantovani, Alberto

“…Chronic and persistent inflammation contributes to cancer development and can predispose to carcinogenesis. Infection-driven inflammations are involved in the…”
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Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin by Robertson, James C, Hurley, Nate C, Tortorici, Marcello, Ciossani, Giuseppe, Borrello, Maria Teresa, Vellore, Nadeem A, Ganesan, A, Mattevi, Andrea, Baron, Riccardo

“…Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs. No therapeutic that…”
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Structural Characterization and Antimicrobial Evaluation of Atractyloside, Atractyligenin, and 15-Didehydroatractyligenin Methyl Ester by Brucoli, Federico, Borrello, Maria T, Stapleton, Paul, Parkinson, Gary N, Gibbons, Simon

“…We report the first complete structure elucidation of the ent-kaurane diterpenoid glycoside atractyloside (1) by means of NMR and X-ray diffractometry…”
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Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism by Mazzoni, Mara, Mauro, Giuseppe, Erreni, Marco, Romeo, Paola, Minna, Emanuela, Vizioli, Maria Grazia, Belgiovine, Cristina, Rizzetti, Maria Grazia, Pagliardini, Sonia, Avigni, Roberta, Anania, Maria Chiara, Allavena, Paola, Borrello, Maria Grazia, Greco, Angela

“…Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and…”
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BRAF Inhibitors Induce Feedback Activation of RAS Pathway in Thyroid Cancer Cells by Bonaldi, Elisa, Gargiuli, Chiara, De Cecco, Loris, Micali, Arianna, Rizzetti, Maria Grazia, Greco, Angela, Borrello, Maria Grazia, Minna, Emanuela

“…is the most frequent oncogenic mutation identified in papillary thyroid cancer (PTC). In PTC patients who do not respond to standard treatment, BRAF inhibitors…”
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miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma by Minna, Emanuela, Romeo, Paola, Dugo, Matteo, De Cecco, Loris, Todoerti, Katia, Pilotti, Silvana, Perrone, Federica, Seregni, Ettore, Agnelli, Luca, Neri, Antonino, Greco, Angela, Borrello, Maria Grazia

“…Papillary Thyroid Carcinoma (PTC) is the most frequent thyroid cancer. Although several PTC-specific miRNA profiles have been reported, only few upregulated…”
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The dependence receptor Ret induces apoptosis in somatotrophs through a Pit‐1/p53 pathway, preventing tumor growth by Cañibano, Carmen, Rodriguez, Noela L, Saez, Carmen, Tovar, Sulay, Garcia‐Lavandeira, Montse, Borrello, Maria Grazia, Vidal, Anxo, Costantini, Frank, Japon, Miguel, Dieguez, Carlos, Alvarez, Clara V

“…Somatotrophs are the only pituitary cells that express Ret, GFRα1 and GDNF. This study investigated the effects of Ret in a somatotroph cell line, in primary…”
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The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer by Colombo, Carla, Minna, Emanuela, Gargiuli, Chiara, Muzza, Marina, Dugo, Matteo, De Cecco, Loris, Pogliaghi, Gabriele, Tosi, Delfina, Bulfamante, Gaetano, Greco, Angela, Fugazzola, Laura, Borrello, Maria Grazia

“…Abstract Background Papillary thyroid cancer (PTC) is the most frequent endocrine tumor. Radioiodine (RAI) treatment is highly effective in these tumors, but…”
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miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma by Minna, Emanuela, Romeo, Paola, De Cecco, Loris, Dugo, Matteo, Cassinelli, Giuliana, Pilotti, Silvana, Degl'Innocenti, Debora, Lanzi, Cinzia, Casalini, Patrizia, Pierotti, Marco A, Greco, Angela, Borrello, Maria Grazia

“…Thyroid cancer incidence is rapidly increasing. Papillary Thyroid Carcinoma (PTC), the most frequent hystotype, usually displays good prognosis, but no…”
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Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas by Degl'Innocenti, Debora, Alberti, Chiara, Castellano, Giancarlo, Greco, Angela, Miranda, Claudia, Pierotti, Marco A, Seregni, Ettore, Borrello, Maria Grazia, Canevari, Silvana, Tomassetti, Antonella

“…Papillary thyroid carcinoma (PTCs), the most frequent thyroid cancer, is usually not life threatening, but may recur or progress to aggressive forms resistant…”
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Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma by Minna, Emanuela, Brich, Silvia, Todoerti, Katia, Pilotti, Silvana, Collini, Paola, Bonaldi, Elisa, Romeo, Paola, Cecco, Loris De, Dugo, Matteo, Perrone, Federica, Busico, Adele, Vingiani, Andrea, Bersani, Ilaria, Anichini, Andrea, Mortarini, Roberta, Neri, Antonino, Pruneri, Giancarlo, Greco, Angela, Borrello, Maria Grazia

“…Thyroid carcinoma (TC) comprises several histotypes with different aggressiveness, from well (papillary carcinoma, PTC) to less differentiated forms (poorly…”
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Genomic and transcriptomic analyses of thyroid cancers identify DICER1 somatic mutations in adult follicular-patterned RAS-like tumors by Minna, Emanuela, Devecchi, Andrea, Pistore, Federico, Paolini, Biagio, Mauro, Giuseppe, Penso, Donata Alda, Pagliardini, Sonia, Busico, Adele, Pruneri, Giancarlo, De Cecco, Loris, Borrello, Maria Grazia, Sensi, Marialuisa, Greco, Angela

“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer (TC). Several genomic and transcriptomic studies explored the molecular landscape…”
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Inflammation and cancer: The oncogene-driven connection by Borrello, Maria Grazia, Degl’Innocenti, Debora, Pierotti, Marco A

“…Abstract Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell…”
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