Liver Function Tests and FIB-4 Score as Predictors of Severity in COVID-19 Patients from the South-West of Romania

Background: The coronavirus disease 2019 pandemic (COVID-19) is the most important global health crisis to date. In this study, we performed an analysis to find the association between liver damage, FIB-4 score and the severity of COVID-19 disease. Methods: We included a total of 580 patients that t...

Full description

Saved in:

Bibliographic Details
Published in:	Life (Basel, Switzerland) Vol. 12; no. 7; p. 934
Main Authors:	Kamal, Adina M., Dumitrescu, Florentina, Mită, Adrian, Săbiescu, Denisa M., Alexandru, Dragoș O., Gheorghe, Codruța E., Filip, Monalisa M., Ionescu-Ciocâlteu, Adriana, Maria, Daniela T., Kamal, Diana, Kamal, Constantin K.
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 22-06-2022 MDPI
Subjects:	Antibiotics Asymptomatic Blood pressure Body mass Body mass index Body size Cardiovascular diseases Coronary artery disease Coronaviruses Corticoids Corticosteroids COVID-19 Diabetes Diabetes mellitus Enzymes FIB-4 score Global health Heart diseases Hospitalization Hypertension Infections Injuries Liver Liver diseases Oxygen saturation Pandemics Patients Phosphatase Pneumonia Public health SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 severity Viral diseases Viruses Romania
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background: The coronavirus disease 2019 pandemic (COVID-19) is the most important global health crisis to date. In this study, we performed an analysis to find the association between liver damage, FIB-4 score and the severity of COVID-19 disease. Methods: We included a total of 580 patients that tested positive for SARS-CoV-2 infection and were hospitalized. No patient included had any known history of liver disease. Liver function tests were performed, and FIB-4 score was calculated in order to assess their involvement in the disease progression. Results: More than half of the patients had elevated liver function tests. Age, high body mass index, associated heart disease and diabetes were associated with poor outcome. Corticosteroids, antibiotics, and anticoagulants strongly correlated with liver injuries. Liver impairment and injury, as well as a FIB-4 score higher than 3.5, also correlated with higher degrees of disease severity. Conclusion: Liver injury and elevated FIB-4 score were associated with poor clinical outcome and disease severity, as well as being a valuable tool to predict COVID-19-related mortality.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2075-1729 2075-1729
DOI:	10.3390/life12070934