Search Results - "Maria, Berdasco"

Clinical epigenetics: seizing opportunities for translation by Berdasco, María, Esteller, Manel

“…Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in…”
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Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry by Berdasco, María, Esteller, Manel

“…Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human…”
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Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? by Hanly, David J., Esteller, Manel, Berdasco, María

“…Of the diverse array of putative molecular and biological functions assigned to long non-coding RNAs (lncRNAs), one attractive perspective in epigenetic…”
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Towards a druggable epitranscriptome: Compounds that target RNA modifications in cancer by Berdasco, María, Esteller, Manel

“…Epitranscriptomics is an exciting emerging area that studies biochemical modifications of RNA. The field has been opened up by the technical efforts of the…”
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Genetic syndromes caused by mutations in epigenetic genes by Berdasco, María, Esteller, Manel

“…The orchestrated organization of epigenetic factors that control chromatin dynamism, including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and…”
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Hot topics in epigenetic mechanisms of aging: 2011 by Berdasco, María, Esteller, Manel

“…Summary Aging is a complex process that results in compromised biological functions of the organism and increased susceptibility to disease and death. Although…”
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Towards a more precise therapy in cancer: Exploring epigenetic complexity by Cossío, Fernando P., Esteller, Manel, Berdasco, María

“…A plethora of preclinical evidences suggests that pharmacological targeting of epigenetic dysregulation is a potent strategy to combat human diseases…”
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Ethical implications of epigenetics in the era of personalized medicine by Santaló, Josep, Berdasco, María

“…Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the field of…”
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DNA methylation in stem cell renewal and multipotency by Berdasco, María, Esteller, Manel

“…Owing to their potential for differentiation into multiple cell types, multipotent stem cells extracted from many adult tissues are an attractive stem cell…”
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Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression by Perazzoli, Gloria, Prados, Jose, Ortiz, Raul, Caba, Octavio, Cabeza, Laura, Berdasco, Maria, Gónzalez, Beatriz, Melguizo, Consolación

“…The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main reasons why…”
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Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders by Delgado-Morales, Raúl, Agís-Balboa, Roberto Carlos, Esteller, Manel, Berdasco, María

“…Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated…”
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Role for RNAi in the Selective Correction of DNA Methylation Defects by Teixeira, Felipe Karam, Heredia, Fabiana, Sarazin, Alexis, Roudier, François, Boccara, Martine, Ciaudo, Constance, Cruaud, Corinne, Poulain, Julie, Berdasco, Maria, Fraga, Mario F, Voinnet, Olivier, Wincker, Patrick, Esteller, Manel, Colot, Vincent

“…DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, which suggests that this modification must be tightly…”
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Quantitative comparison of DNA methylation assays for biomarker development and clinical applications by Bock, Christoph, Halbritter, Florian, Carmona, Francisco J, Tierling, Sascha, Datlinger, Paul, Assenov, Yassen, Berdasco, María, Bergmann, Anke K, Booher, Keith, Busato, Florence, Campan, Mihaela, Dahl, Christina, Dahmcke, Christina M, Diep, Dinh, Fernández, Agustín F, Gerhauser, Clarissa, Haake, Andrea, Heilmann, Katharina, Holcomb, Thomas, Hussmann, Dianna, Ito, Mitsuteru, Kläver, Ruth, Kreutz, Martin, Kulis, Marta, Lopez, Virginia, Nair, Shalima S, Paul, Dirk S, Plongthongkum, Nongluk, Qu, Wenjia, Queirós, Ana C, Reinicke, Frank, Sauter, Guido, Schlomm, Thorsten, Statham, Aaron, Stirzaker, Clare, Strogantsev, Ruslan, Urdinguio, Rocío G, Walter, Kimberly, Weichenhan, Dieter, Weisenberger, Daniel J, Beck, Stephan, Clark, Susan J, Esteller, Manel, Ferguson-Smith, Anne C, Fraga, Mario F, Guldberg, Per, Hansen, Lise Lotte, Laird, Peter W, Martín-Subero, José I, Nygren, Anders O H, Peist, Ralf, Plass, Christoph, Shames, David S, Siebert, Reiner, Sun, Xueguang, Tost, Jörg, Walter, Jörn, Zhang, Kun

“…A multicenter comparison of DNA methylation assays identifies robust methods for translational research and clinical diagnostics. DNA methylation patterns are…”
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Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma by Berdasco, María, Ropero, Santiago, Setien, Fernando, Fraga, Mario F, Lapunzina, Pablo, Losson, Régine, Alaminos, Miguel, Cheung, Nai-Kong, Rahman, Nazneen, Esteller, Manel

“…Sotos syndrome is an autosomal dominant condition characterized by overgrowth resulting in tall stature and macrocephaly, together with an increased risk of…”
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An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins by Yuan, Wei, Xia, Yudong, Bell, Christopher G., Yet, Idil, Ferreira, Teresa, Ward, Kirsten J., Gao, Fei, Loomis, A. Katrina, Hyde, Craig L., Wu, Honglong, Lu, Hanlin, Liu, Yuan, Small, Kerrin S., Viñuela, Ana, Morris, Andrew P., Berdasco, María, Esteller, Manel, Brosnan, M. Julia, Deloukas, Panos, McCarthy, Mark I., John, Sally L., Bell, Jordana T., Wang, Jun, Spector, Tim D.

“…DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide…”
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Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow-up multicenter study by González, Carlos A., Sanz-Anquela, José Miguel, Companioni, Osmel, Bonet, Catalina, Berdasco, María, López, Consuelo, Mendoza, Jorge, Martín-Arranz, Mª Dolores, Rey, Enrique, Poves, Elvira, Espinosa, Laura, Barrio, Jesús, Torres, Mª Ángeles, Cuatrecasas, Miriam, Elizalde, Ignasi, Bujanda, Luis, Garmendia, Maddi, Ferrández, Ángel, Muñoz, Guillermo, Andreu, Victoria, Paules, Mª Jose, Lario, Sergio, Ramírez, Mª Jose, Gisbert, Javier P.

“…Background and Aim In high or moderate risk populations, periodic surveillance of patients at risk of progression from gastric precursor lesions (PL) to…”
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A DNA methylation fingerprint of 1628 human samples by Fernandez, Agustin F, Assenov, Yassen, Martin-Subero, Jose Ignacio, Balint, Balazs, Siebert, Reiner, Taniguchi, Hiroaki, Yamamoto, Hiroyuki, Hidalgo, Manuel, Tan, Aik-Choon, Galm, Oliver, Ferrer, Isidre, Sanchez-Cespedes, Montse, Villanueva, Alberto, Carmona, Javier, Sanchez-Mut, Jose V, Berdasco, Maria, Moreno, Victor, Capella, Gabriel, Monk, David, Ballestar, Esteban, Ropero, Santiago, Martinez, Ramon, Sanchez-Carbayo, Marta, Prosper, Felipe, Agirre, Xabier, Fraga, Mario F, Graña, Osvaldo, Perez-Jurado, Luis, Mora, Jaume, Puig, Susana, Prat, Jaime, Badimon, Lina, Puca, Annibale A, Meltzer, Stephen J, Lengauer, Thomas, Bridgewater, John, Bock, Christoph, Esteller, Manel

“…Most of the studies characterizing DNA methylation patterns have been restricted to particular genomic loci in a limited number of human samples and…”
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Discovery of novel DNA methylation biomarkers for non‐invasive sporadic breast cancer detection in the Latino population by Cappetta, Mónica, Fernandez, Lucía, Brignoni, Lucía, Artagaveytia, Nora, Bonilla, Carolina, López, Miguel, Esteller, Manel, Bertoni, Bernardo, Berdasco, María

“…Epigenetic alterations are already being incorporated as robust biomarkers for prediction of cancer risk. Despite this success, validation in specific…”
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DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders by Berdasco, María, Gómez, Antonio, Rubio, Marcos J., Català-Mora, Jaume, Zanón-Moreno, Vicente, Lopez, Miguel, Hernández, Cristina, Yoshida, Shigeo, Nakama, Takahito, Ishikawa, Keijiro, Ishibashi, Tatsuro, Boubekeur, Amina M., Louhibi, Lotfi, Pujana, Miguel A, Sayols, Sergi, Setien, Fernando, Corella, Dolores, de Torres, Carmen, Parareda, Andreu, Mora, Jaume, Zhao, Ling, Zhang, Kang, Lleonart, Matilde E., Alonso, Javier, Simó, Rafael, Caminal, Josep M., Esteller, Manel

“…This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their…”
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Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control by Oriol-Tordera, Bruna, Berdasco, Maria, Llano, Anuska, Mothe, Beatriz, Gálvez, Cristina, Martinez-Picado, Javier, Carrillo, Jorge, Blanco, Julià, Duran-Castells, Clara, Ganoza, Carmela, Sanchez, Jorge, Clotet, Bonaventura, Calle, Maria Luz, Sánchez-Pla, Alex, Esteller, Manel, Brander, Christian, Ruiz-Riol, Marta

“…GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge…”
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