Tumor necrosis factor gene expression in regular hemodialysis patients

Tumor necrosis factor gene expression in regular hemodialysis patients

This study evaluates tumor necrosis factor (TNF)-alfa gene expression in patients with end-stage renal disease (ESRD) on regular hemodialysis as an expression of cardiovascular disease (CVD) risk even on a sub-clinical level and its relation to some of the parameters incriminated in the pathogenesis...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation Vol. 26; no. 3; pp. 460 - 467
Main Authors: Sharif, Mayy, Farid, Rim Jan, al-Haddad, Himmat E., Sami, Tariq M., Sharaf al-Din, Usamah A., Mari, Muhammad A.
Format: Journal Article
Language:English
Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01-05-2015
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects:
Age
Analysis
Atherosclerosis
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Cholesterol
Cytokines
Diagnosis
Gangrene
Gene expression
Health aspects
Hemodialysis
Inflammation
Kidney diseases
Medical prognosis
Patients
Risk factors
Studies
Tumor necrosis factor
Tumor necrosis factor-TNF
الخلايا البلعمية
الفشل الكلوي
المرضى
عامل نخر الورم
غسيل الكلى
مسببات الأمراض
Saudi Arabia
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Summary:This study evaluates tumor necrosis factor (TNF)-alfa gene expression in patients with end-stage renal disease (ESRD) on regular hemodialysis as an expression of cardiovascular disease (CVD) risk even on a sub-clinical level and its relation to some of the parameters incriminated in the pathogenesis and the establishment of uremic arteriopathy. A total of 51 patients with ESRD on regular hemodialysis and 20 healthy subjects matching in age and gender as a control group were recruited. All selected cases were subjected to serum lipid profile, Creactive protein (CRP), TNF-alfa gene expression and Doppler study of carotid arteries to estimate carotid intimal media thickness (cIMT). Serum triglycerides (TGS) level (P < 0.001), CRP positivity (P = 0.002), relative quantification (RQ) of TNF-alfa gene expression (P = 0.007) and cIMT (P = 0.02) were significantly higher while high-density lipoprotein (HDL) level (P < 0.001) was significantly lower among cases compared with controls. RQ showed a significant positive correlation with CRP titer (rho = 0.583, P = 0.011). Results also showed a significant strong negative correlation between with CRP titer and cIMT (rho = -0.590, P = 0.010). CRP titer showed only a significant strong negative correlation with age (rho = -0.589, P = 0.01) and positive correlation with HDL (rho = 0.51, P = 0.031). Patients with ESRD have increased gene expression of TNF-alfa and CRP titer together with increased atherosclerosis as expressed by increased cIMT.
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ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.157309