Search Results - "Mari, Montserrat"

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease by de Gregorio, Estefanía, Colell, Anna, Morales, Albert, Marí, Montserrat

“…Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue…”
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Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress by Morales, Albert, Marí, Montserrat, Lestón, Laura, de Dios, Cristina, Roca-Agujetas, Vicente, Colell, Anna

“…Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with…”
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Mitochondrial Oxidative and Nitrosative Stress as a Therapeutic Target in Diseases by Marí, Montserrat, Colell, Anna

“…Mitochondria are fundamental to life [...]…”
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IGFBP-3: So Much More Than an IGF1/2 Binding Protein by Marí, Montserrat

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Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation by Bárcena, Cristina, Stefanovic, Milica, Tutusaus, Anna, Joannas, Leonel, Menéndez, Anghara, García-Ruiz, Carmen, Sancho-Bru, Pau, Marí, Montserrat, Caballeria, Joan, Rothlin, Carla V, Fernández-Checa, José C, de Frutos, Pablo García, Morales, Albert

“…Background & Aims Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development,…”
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Hepatocellular Carcinoma: Molecular Pathogenesis and Therapeutic Advances by Cucarull, Blanca, Tutusaus, Anna, Rider, Patricia, Hernáez-Alsina, Tania, Cuño, Carlos, García de Frutos, Pablo, Colell, Anna, Marí, Montserrat, Morales, Albert

“…Hepatocellular carcinoma (HCC), the most common form of liver cancer, continues to be a serious medical problem with poor prognosis, without major therapeutic…”
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Dynamic changes in immune cell populations by AXL kinase targeting diminish liver inflammation and fibrosis in experimental MASH by Grøndal, Sturla Magnus, Tutusaus, Anna, Boix, Loreto, Reig, Maria, Blø, Magnus, Hodneland, Linn, Gausdal, Gro, Jackson, Akil, Garcia de Frutos, Pablo, Lorens, James Bradley, Morales, Albert, Marí, Montserrat

“…Metabolic dysfunction-associated steatohepatitis (MASH) is a significant health concern with limited treatment options. AXL, a receptor tyrosine kinase…”
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Redox control of liver function in health and disease by Marí, Montserrat, Colell, Anna, Morales, Albert, von Montfort, Claudia, Garcia-Ruiz, Carmen, Fernández-Checa, José C

“…Reactive oxygen species (ROS), a heterogeneous population of biologically active intermediates, are generated as by-products of the aerobic metabolism and…”
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Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis by Moles, Anna, Tarrats, Núria, Morales, Albert, Domínguez, Marlene, Bataller, Ramón, Caballería, Juan, García-Ruiz, Carmen, Fernández-Checa, José C, Marí, Montserrat

“…The mechanisms linking hepatocellular death, hepatic stellate cell (HSC) activation, and liver fibrosis are largely unknown. Here, we investigate whether…”
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Genetic and clinical data reinforce the role of GAS6 and TAM receptors in liver fibrosis by Marí, Montserrat, Tutusaus, Anna, García de Frutos, Pablo, Morales, Albert

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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis by de Dios, Cristina, Abadin, Xenia, Roca-Agujetas, Vicente, Jimenez-Martinez, Marina, Morales, Albert, Trullas, Ramon, Mari, Montserrat, Colell, Anna

“…Persistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of…”
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Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation by de Mingo, Álvaro, de Gregorio, Estefanía, Moles, Anna, Tarrats, Núria, Tutusaus, Anna, Colell, Anna, Fernandez-Checa, Jose C, Morales, Albert, Marí, Montserrat

“…Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF- κ B-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or…”
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Ileal FGF15 contributes to fibrosis‐associated hepatocellular carcinoma development by Uriarte, Iker, Latasa, M. Ujue, Carotti, Simone, Fernandez‐Barrena, Maite G., Garcia‐Irigoyen, Oihane, Elizalde, Maria, Urtasun, Raquel, Vespasiani‐Gentilucci, Umberto, Morini, Sergio, Mingo, Alvaro, Mari, Montserrat, Corrales, Fernando J., Prieto, Jesus, Berasain, Carmen, Avila, Matias A.

“…Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut‐derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also…”
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Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility by Bosch, Marta, Marí, Montserrat, Herms, Albert, Fernández, Ana, Fajardo, Alba, Kassan, Adam, Giralt, Albert, Colell, Anna, Balgoma, David, Barbero, Elisabet, González-Moreno, Elena, Matias, Nuria, Tebar, Francesc, Balsinde, Jesús, Camps, Marta, Enrich, Carlos, Gross, Steven P., García-Ruiz, Carmen, Pérez-Navarro, Esther, Fernández-Checa, José C., Pol, Albert

“…Caveolins (CAVs) are essential components of caveolae, plasma membrane invaginations with reduced fluidity, reflecting cholesterol accumulation [1]. CAV…”
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Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress by de Dios, Cristina, Bartolessis, Isabel, Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, Mari, Montserrat, Morales, Albert, Colell, Anna

“…Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the…”
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Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis by Tarrats, Núria, Moles, Anna, Morales, Albert, García‐Ruiz, Carmen, Fernández‐Checa, José C., Marí, Montserrat

“…Tumor necrosis factor (TNF) has been implicated in the progression of many chronic liver diseases leading to fibrosis; however, the role of TNF in fibrogenesis…”
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Induction of the Inflammasome Pathway by Tyrosine Kinase Inhibitors Provides an Actionable Therapeutic Target for Hepatocellular Carcinoma by Tutusaus, Anna, Sanduzzi-Zamparelli, Marco, Boix, Loreto, Rider, Patricia, Subías, Silvia, García de Frutos, Pablo, Colell, Anna, Marí, Montserrat, Reig, María, Morales, Albert

“…During the last decade, tyrosine kinase inhibitors (TKIs) sorafenib and regorafenib have been standard systemic treatments for advanced hepatocellular…”
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ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading by Fernandez, Anna, Matias, Núria, Fucho, Raquel, Ribas, Vicente, Von Montfort, Claudia, Nuño, Natalia, Baulies, Anna, Martinez, Laura, Tarrats, Núria, Mari, Montserrat, Colell, Anna, Morales, Albert, Dubuquoy, Laurent, Mathurin, Philippe, Bataller, Ramón, Caballeria, Joan, Elena, Montserrat, Balsinde, Jesus, Kaplowitz, Neil, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C

“…Background & Aims The pathogenesis of alcohol-induced liver disease (ALD) is poorly understood. Here, we examined the role of acid sphingomyelinase (ASMase) in…”
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Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury by Marí, Montserrat, Morales, Albert

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Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome by Morales, Albert, Rojo Rello, Silvia, Cristóbal, Helena, Fiz-López, Aida, Arribas, Elisa, Marí, Montserrat, Tutusaus, Anna, de la Cal-Sabater, Paloma, Nicolaes, Gerry A F, Ortiz-Pérez, José T, Bernardo, David, García de Frutos, Pablo

“…Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, and MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for…”
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