Search Results - "Margulies, K. B."

A Needleless Liquid Jet Injection Delivery Method for Cardiac Gene Therapy: a Comparative Evaluation Versus Standard Routes of Delivery Reveals Enhanced Therapeutic Retention and Cardiac Specific Gene Expression by Fargnoli, A. S., Katz, M. G., Williams, R. D., Margulies, K. B., Bridges, Charles R.

“…This study evaluates needleless liquid jet method and compares it with three common experimental methods: (1) intramuscular injection (IM), (2) left…”
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Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure by DIPLA, K, MATTIELLO, J. A, JEEVANANDAM, V, HOUSER, S. R, MARGULIES, K. B

“…The failing myocardium is characterized by decreased force production, slowed relaxation, and depressed responses to beta-adrenergic stimulation. In some heart…”
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Regression of cellular hypertrophy after left ventricular assist device support by ZAFEIRIDIS, A, JEEVANANDAM, V, HOUSER, S. R, MARGULIES, K. B

“…Although multiple studies have shown that the left ventricular assist device (LVAD) improves distorted cardiac geometry, the pathological mechanisms of the…”
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The Sarcoplasmic Reticulum and the Na+/Ca2+ Exchanger Both Contribute to the Ca2+ Transient of Failing Human Ventricular Myocytes by Dipla, Konstantina, Mattiello, Julian A, Margulies, Kenneth B, Jeevanandam, Valluvan, Houser, Steven R

“…Our objective was to determine the respective roles of the sarcoplasmic reticulum (SR) and the Na exchanger in the small, slowly decaying Ca transients of…”
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Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy by Altemose, G T, Gritsus, V, Jeevanandam, V, Goldman, B, Margulies, K B

“…Left ventricular assist devices (LVAD) provide lifesaving circulatory support to patients awaiting heart transplantation. To date, the extent to which…”
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Cytomegalovirus‐Responsive CD8+ T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease by Higdon, L. E., Trofe‐Clark, J., Liu, S., Margulies, K. B., Sahoo, M. K., Blumberg, E., Pinsky, B. A., Maltzman, J. S.

“…Cytomegalovirus (CMV) is a major cause of morbidity and mortality in solid organ transplant recipients. Approximately 60% of adults are CMV seropositive,…”
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Increased endothelin in experimental heart failure by MARGULIES, K. B, HILDEBRAND, F. L, LERMAN, A, PERRELLA, M. A, BURNETT, J. C

“…Recent studies demonstrate that endothelin, a potent endogenous vasoconstrictor peptide, circulates in plasma of normal animals and humans. However, the role…”
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Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts by Fedalen, P A, Piacentino, 3rd, V, Jeevanandam, V, Fisher, C, Greene, J, Margulies, K B, Houser, S R, Furukawa, S, Singhal, A K, Goldman, B I

“…Hearts from non-heart-beating organ donors are not transplanted because of risk of ischemia-reperfusion injury. We tested whether pharmacologic…”
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Role of endothelin receptor subtypes in the in vivo regulation of renal function by Clavell, A L, Stingo, A J, Margulies, K B, Brandt, R R, Burnett, Jr, J C

“…Endothelin (ET) is a potent vasoconstrictor peptide of endothelial origin, which at low doses results in renal vasoconstriction and diuresis with variable…”
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Endothelin in experimental congestive heart failure in the anesthetized dog by Cavero, P G, Miller, W L, Heublein, D M, Margulies, K B, Burnett, Jr, J C

“…Studies were performed in anesthetized dogs to determine plasma endothelin (ET) concentrations in the presence and absence of experimental congestive heart…”
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Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes by Piacentino, Valentino, Weber, Christopher R, Chen, Xiongwen, Weisser-Thomas, Jutta, Margulies, Kenneth B, Bers, Donald M, Houser, Steven R

“…ABSTRACT—Depressed contractility is a central feature of the failing human heart and has been attributed to altered [Ca]i. This study examined the respective…”
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Is Depressed Myocyte Contractility Centrally Involved in Heart Failure? by Houser, Steven R, Margulies, Kenneth B

“…ABSTRACT—This review examines the evidence for and against the hypothesis that abnormalities in cardiac contractility initiate the heart failure syndrome and…”
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Cardiorenal actions of neutral endopeptidase inhibition in experimental congestive heart failure by CAVERO, P. G, MARGULIES, K. B, WINAVER, J, SEYMOUR, A. A, DELANEY, N. G, BURNETT, J. C

“…The present studies were designed to determine the action of neutral endopeptidase inhibition (NEP-I), an inhibitor of the degradation of atrial natriuretic…”
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Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function by Perrella, M A, Hildebrand, Jr, F L, Margulies, K B, Burnett, Jr, J C

“…The endothelium has emerged as an important modulator of vascular tone by producing both vasodilating and vasoconstricting substances. In vitro studies have…”
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ANF-mediated renal cGMP generation in congestive heart failure by Margulies, K B, Heublein, D M, Perrella, M A, Burnett, Jr, J C

“…Previous studies have demonstrated that the biological actions of atrial natriuretic factor (ANF) are mediated via increases in its intracellular second…”
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Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure by MARGULIES, K. B, PERRELLA, M. A, MCKINLEY, L. J, BURNETT, J. C

“…The renal natriuretic actions of endogenous atrial natriuretic factor are enhanced by neutral endopeptidase inhibition (NEP-I). Recognizing that activation of…”
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Endothelin: a new cardiovascular regulatory peptide by Lerman, A, Hildebrand, Jr, F L, Margulies, K B, O'Murchu, B, Perrella, M A, Heublein, D M, Schwab, T R, Burnett, Jr, J C

“…Endothelin, a recently discovered peptide produced by endothelial cells, contracts vascular strips in vitro with greater potency than any previously known…”
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The role of neutral endopeptidase in dogs with evolving congestive heart failure by MARGULIES, K. B, BARCLAY, P. L, BURNETT, J. C

“…Recent studies suggest that neurohumoral mechanisms including decreased renal responses to increases in atrial natriuretic factor (ANF) play a central role in…”
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Patients with end-stage congestive heart failure treated with β-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance by KUBO, Hajime, MARGULIES, Kenneth B, PIACENTINO, Valentino III, GAUGHAN, John P, HOUSER, Steven R

“…Alterations in Ca(2+)-handling proteins are thought to underlie the deranged Ca(2+) transients that contribute to deterioration of cardiac function in…”
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Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure by HARDING, John D, PIACENTINO, Valentino III, GAUGHAN, John P, HOUSER, Steven R, MARGULIES, Kenneth B

“…Recognizing that mechanical circulatory support with a left ventricular assist device (LVAD) induces changes in myocardial structure and contractile function,…”
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