Search Results - "Margulies, Inger"

Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell Leukemia by KREITMAN, Robert J, STETLER-STEVENSON, Maryalice, MARGULIES, Inger, NOEL, Pierre, FITZGERALD, David J. P, WILSON, Wyndham H, PASTAN, Ira

“…To conduct a phase II trial in chemoresistant hairy cell leukemia (HCL) with BL22, a recombinant anti-CD22 immunotoxin which showed phase I activity in HCL…”
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Improved Cytotoxic Activity toward Cell Lines and Fresh Leukemia Cells of a Mutant Anti-CD22 Immunotoxin Obtained by Antibody Phage Display by SALVATORE, Giuliana, BEERS, Richard, MARGULIES, Inger, KREITMAN, Robert J, PASTAN, Ira

“…Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins that are being developed for the…”
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Responses in Refractory Hairy Cell Leukemia to a Recombinant Immunotoxin by Kreitman, Robert J., Wilson, Wyndham H., Robbins, David, Margulies, Inger, Stetler-Stevenson, Maryalice, Waldmann, Thomas A., Pastan, Ira

“…We report major responses in 4 of 4 patients with hairy cell leukemia (HCL) who have recently been treated on a phase I trial with the recombinant immunotoxin…”
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Minimal Residual Disease in Hairy Cell Leukemia Patients Assessed by Clone-Specific Polymerase Chain Reaction by ARONS, Evgeny, MARGULIES, Inger, SORBARA, Lynn, RAFFELD, Mark, STETLER-STEVENSON, Maryalice, PASTAN, Ira, KREITMAN, Robert J

“…Cladribine induces long-term complete remission in hairy cell leukemia (HCL) patients but does not clear minimal residual disease (MRD) according to…”
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Cytotoxic Activity of Disulfide-stabilized Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) toward Fresh Malignant Cells from Patients with B-Cell Leukemias by KREITMAN, R. J, MARGULIES, I, STETLER-STEVENSON, M, WANG, Q.-C, FITZGERALD, D. J. P, PASTAN, I

“…Chemical conjugates of anti-CD22 monoclonal antibodies and toxins have been used to treat CD22+ hematological malignancies. A new anti-CD22 recombinant…”
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Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development by Rosengard, Ariella M, Krutzsch, Henry C, Shearn, Allen, Biggs, Joseph R, Barker, Edward, Margulies, Inger M. K, King, C. Richter, Liotta, Lance A, Steeg, Patricia S

“…Tumour metastasis is the principal cause of death for cancer patients. We have identified the nm23 gene, for which RNA levels are reduced in tumour cells of…”
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Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines by Brown, P D, Levy, A T, Margulies, I M, Liotta, L A, Stetler-Stevenson, W G

“…The regulation of Mr 72,000 type IV collagenase and interstitial collagenase expression was studied in vitro. Three tumorigenic human cell lines were used,…”
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Hairy Cell Leukemia, a B-Cell Neoplasm That Is Particularly Sensitive to the Cytotoxic Effect of Anti-Tac(Fv)-PE38 (LMB-2) by ROBBINS, D. H, MARGULIES, I, STETLER-STEVENSON, M, KREITMAN, R. J

“…Anti-Tac(Fv)-PE38 (LMB-2) is a recombinant, single-chain immunotoxin composed of the variable domains of the anti-Tac (anti-CD25) monoclonal antibody fused to…”
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Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting Mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma by HASSAN, R, VINER, J. L, WANG, Q.-C, MARGULIES, I, KREITMAN, R. J, PASTAN, I

“…Mesothelin, a differentiation antigen, is a 40-kD glycosylphosphatidylinositol-linked cell-surface glycoprotein, that is present on the surface of normal…”
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A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity by Weldon, John E., Xiang, Laiman, Chertov, Oleg, Margulies, Inger, Kreitman, Robert J., FitzGerald, David J., Pastan, Ira

“…Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated…”
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Cloning and characterization of human tumor cell interstitial collagenase by Templeton, N S, Brown, P D, Levy, A T, Margulies, I M, Liotta, L A, Stetler-Stevenson, W G

“…A full-length complementary DNA (cDNA) for interstitial collagenase was isolated from an A2058 melanoma cDNA library using the pCD-X Okayama-Berg vector. The…”
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111Indium‐labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin by Hassan, Raffit, Wu, Chuanchu, Brechbiel, Martin W., Margulies, Inger, Kreitman, Robert J., Pastan, Ira

“…The monoclonal antibody (MAb) K1 is a murine IgG1 that recognizes mesothelin, a differentiation antigen present on mesothelium which is highly expressed on…”
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Soluble CD22 as a tumor marker for hairy cell leukemia by Matsushita, Kakushi, Margulies, Inger, Onda, Masanori, Nagata, Satoshi, Stetler-Stevenson, Maryalice, Kreitman, Robert J.

“…CD22 is an important immunotherapeutic target on B-cell malignancies, particularly hairy cell leukemia (HCL), but its soluble extracellular domain, sCD22, has…”
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Molecular Characteristic of Variant and Classic Hairy Cell Leukemia by Arons, Evgeny, Suntum, Tara, Sunshine, Joel, Orthwein, Anna, Margulies, Inger, Stetler-Stevenson, Maryalice, Kreitman, Robert

“…10–20% of patients with hairy cell leukemia (HCL) have a variant (HCLv) and present with high tumor burden in spleen and peripheral blood, and are less…”
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PRAME expression in hairy cell leukemia by Arons, Evgeny, Suntum, Tara, Margulies, Inger, Yuan, Constance, Stetler-Stevenson, Maryalice, Kreitman, Robert J

“…Abstract PRAME has been proposed as a useful marker for solid tumors and acute B-cell malignancies. Several studies demonstrate expression in CLL. To further…”
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Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration by Guirguis, Raouf, Margulies, Inger, Taraboletti, Giulia, Schiffmann, Elliott, Liotta, Lance

“…Pseudopodia protrusion is a prominent feature of actively motile cells in vitro and invading tumour cells in vivo; however, the function and regulation of…”
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Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma by Margulies, I M, Höyhtyä, M, Evans, C, Stracke, M L, Liotta, L A, Stetler-Stevenson, W G

“…Accumulating experimental evidence has linked the overproduction of extracellular matrix-degrading metalloproteinases with tumor cell invasion. In the present…”
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Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein by SEETHARAM, S, NODZENSKI, E, BECKETT, M. A, HEIMANN, R, CHA, A, MARGULIES, I, PASTAN, I, KUFE, D. W, WEICHSELBAUM, R. R

“…Strategies to sensitize human tumors that are resistant to apoptosis have been clinically unsuccessful. We demonstrate that a structurally modified chimeric…”
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Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin by Cioce, Vittoria, Margulies, Inger M.K., Sobel, Mark E., Castronovo, Vincent

“…Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin. Normal and neoplastic cells interact with laminin via a variety of…”
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Early events of C-type virus budding in cells infected with a Rauscher leukemia virus temperature-sensitive mutant by Demsey, A., Kawka, D., Galuska, S., Margulies, Inger, Heine, Ursula

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