Search Results - "Margulies, D H"

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition by Murakami, Y, Tian, L, Voss, O H, Margulies, D H, Krzewski, K, Coligan, J E

“…The CD300 receptor family members are a group of molecules that modulate a variety of immune cell processes. We show that mouse CD300b (CLM7/LMIR5), expressed…”
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The Biochemistry and Cell Biology of Antigen Processing and Presentation by Germain, R N, Margulies, D H

“…T lymphocytes with alpha beta receptors recognize antigen in association with the polymorphic products of the class I and class II loci of the major…”
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Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand by Tormo, José, Natarajan, Kannan, Margulies, David H, Mariuzza, Roy A

“…Natural killer (NK) cell function is regulated by NK receptors that interact with MHC class I (MHC-I) molecules on target cells. The murine NK receptor Ly49A…”
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TCR avidity: it's not how strong you make it, it's how you make it strong by Margulies, David H

“…Unlike the BCR, the TCR cannot undergo affinity maturation. However, T cells respond with greater sensitivity to antigen during an immune response. New…”
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Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues by Chen, W, Khilko, S, Fecondo, J, Margulies, D H, McCluskey, J

“…The contribution of major histocompatibility complex (MHC) class I-peptide affinity to immunodominance of particular peptide antigens (Ags) in the class…”
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Crystal Structure of Human CD69:  A C-Type Lectin-Like Activation Marker of Hematopoietic Cells by Natarajan, Kannan, Sawicki, Mark W, Margulies, David H, Mariuzza, Roy A

“…CD69 is a widely expressed type II transmembrane glycoprotein related to the C-type animal lectins that exhibits regulated expression on a variety of cells of…”
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T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity by Corr, Maripat, Slanetz, Alfred E., Boyd, Lisa F., Jelonek, Marie T., Khilko, Sergei, Al-Ramadi, Basel K., Kim, Young Sang, Maher, Stephen E., Alfred L. M. Bothwell, Margulies, David H.

“…The critical discriminatory event in the activation of T lymphocytes bearing αβ T cell receptors (TCRs) is their interaction with a molecular complex…”
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Control of autoimmunity by regulatory T cells by Shevach, E M, McHugh, R S, Thornton, A M, Piccirillo, C, Natarajan, K, Margulies, D H

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The Natural Killer Cell Receptor Ly-49A Recognizes a Peptide-Induced Conformational Determinant on its Major Histocompatibility Complex Class I Ligand by Orihuela, Michael, Margulies, David H., Yokoyama, Wayne M.

“…Natural killer (NK) cells are inhibited from killing cellular targets by major histocompatibility complex (MHC) class I molecules. In the mouse, this can be…”
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Direct detection of major histocompatibility complex class I binding to antigenic peptides using surface plasmon resonance. Peptide immobilization and characterization of binding specificity by KHILKO, S. N, CORR, M, BOYD, L. F, LEES, A, INMAN, J. K, MARGULIES, D. H

“…We have developed model systems in which the binding of purified, genetically engineered, soluble analogues of major histocompatibility complex (MHC) class I…”
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STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORS: Multiple Molecular Solutions to Self, Nonself Discrimination by Natarajan, Kannan, Dimasi, Nazzareno, Wang, Jian, Mariuzza, Roy A, Margulies, David H

“…In contrast to T cell receptors, signal transducing cell surface membrane molecules involved in the regulation of responses by cells of the innate immune…”
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Mapping the Ligand of the NK Inhibitory Receptor Ly49A on Living Cells by Chung, Doo Hyun, Natarajan, Kannan, Boyd, Lisa F, Tormo, Jose, Mariuzza, Roy A, Yokoyama, Wayne M, Margulies, David H

“…We have used a recombinant, biotinylated form of the mouse NK cell inhibitory receptor, Ly49A, to visualize the expression of MHC class I (MHC-I) ligands on…”
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Ly49A allelic variation and MHC class I specificity by Mehta, I K, Wang, J, Roland, J, Margulies, D H, Yokoyama, W M

“…The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears…”
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Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression by Otten, GR, Bikoff, E, Ribaudo, RK, Kozlowski, S, Margulies, DH, Germain, RN

“…We have examined the roles of peptide and beta 2-microglobulin (beta 2m) in regulating the conformation and expression level of class I molecules on the cell…”
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Multiple pathways are involved in the extracellular processing of MHC class I-restricted peptides by Kozlowski, S, Corr, M, Shirai, M, Boyd, LF, Pendleton, CD, Berzofsky, JA, Margulies, DH

“…T cell stimulation by certain class I-restricted antigenic peptides, such as the HIV 1 gp160-derived peptide, P18, requires peptide processing by angiotensin-1…”
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Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule by Takeshita, T, Takahashi, H, Kozlowski, S, Ahlers, JD, Pendleton, CD, Moore, RL, Nakagawa, Y, Yokomuro, K, Fox, BS, Margulies, DH

“…Although several peptides have been found to bind to both class I and class II molecules, the basis for this binding of the same peptide to two classes of MHC…”
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Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules by KOZLOWSKI, S, CORR, M, TAKESHITA, T, BOYD, L. F, PENDLETON, C. D, GERMAIN, R. N, BERZOFSKY, J. A, MARGULIES, D. H

“…T cell stimulation by the human immunodeficiency virus 1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules in a…”
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Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex by Slansky, Jill E, Rattis, Frédérique M, Boyd, Lisa F, Fahmy, Tarek, Jaffee, Elizabeth M, Schneck, Jonathan P, Margulies, David H, Pardoll, Drew M

“…T cell responsiveness to an epitope is affected both by its affinity for the presenting MHC molecule and the affinity of the MHC-peptide complex for TCR. One…”
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Solution binding of an antigenic peptide to a major histocompatibility complex class I molecule and the role of beta 2-microglobulin by Boyd, L F, Kozlowski, S, Margulies, D H

“…The major histocompatibility complex-encoded class I molecule, a noncovalent dimer of a polymorphic 45-kDa heavy chain and a nonpolymorphic 12-kDa beta…”
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A Recombinant, Soluble, Single-Chain Class I Major Histocompatibility Complex Molecule with Biological Activity by Mage, Michael G., Lee, Li, Ribaudo, Randall K., Corr, Maripat, Kozlowski, Steven, McHugh, Louise, Margulies, David H.

“…Heterodimeric class I major histocompatibility complex molecules, which consist of a 45-kDa heavy-chain and a 12-kDa β2-microglobulin (β2m) light chain, bind…”
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