Search Results - "Margueron, R."

The Multiple Facets of PRC2 Alterations in Cancers by Wassef, M., Margueron, R.

“…Genome sequencing of large cohorts of tumors has revealed that mutations in genes encoding chromatin regulators are frequent in cancer. However, the precise…”
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Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors by Wassef, M., Michaud, A., Margueron, R.

“…EZH2, the main catalytic component of the Polycomb Repressive Complex 2 (PRC2) is apparently upregulated in most solid tumors. Furthermore its expression…”
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Cdyl, a New Partner of the Inactive X Chromosome and Potential Reader of H3K27me3 and H3K9me2 by Escamilla-Del-Arenal, M., da Rocha, S. T., Spruijt, C. G., Masui, O., Renaud, O., Smits, Arne H., Margueron, R., Vermeulen, M., Heard, E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines by Wassef, M., Luscan, A., Battistella, A., Le Corre, S., Li, H., Wallace, M.R., Vidaud, M., Margueron, R.

“…•Despite the advent of CRISPR/CAS9, generating knockout cell lines is laborious.•We present alternative strategies based on homology dependent repair.•A first…”
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ERα and ERβ expression and transcriptional activity are differentially regulated by HDAC inhibitors by DUONG, V, LICZNAR, A, MARGUERON, R, BOULLE, N, BUSSON, M, LACROIX, M, KATZENELLENBOGEN, B. S, CAVAILLES, V, LAZENNEC, G

“…The proliferative action of ERα largely accounts for the carcinogenic activity of estrogens. By contrast, recent data show that ERβ displays tumor-suppressor…”
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Transcriptional and Posttranscriptional Regulation of Fibulin-1 by Estrogens Leads to Differential Induction of Messenger Ribonucleic Acid Variants in Ovarian and Breast Cancer Cells by Bardin, A, Moll, F, Margueron, R, Delfour, C, Chu, M. L, Maudelonde, T, Cavailles, V, Pujol, P

“…Fibulin-1 is an extracellular matrix protein overexpressed in epithelial ovarian and breast cancers. In estrogen receptor (ER)-positive ovarian and breast…”
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Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells by Margueron, R, Licznar, A, Lazennec, G, Vignon, F, Cavailles, V

“…We analysed the antiproliferative activity of various histone deacetylase (HDAC) inhibitors such as trichostatin A (TSA) on human breast cancer cells. We…”
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Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens by Margueron, R, Duong, V, Bonnet, S, Escande, A, Vignon, F, Balaguer, P, Cavailles, V

“…In this study, we have analysed the effects of histone deacetylase (HDAC) inhibition on estrogen receptor (ER) expression and on its transcriptional activity…”
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Chromatin in the nuclear landscape by Beck, D B, Bonasio, R, Kaneko, S, Li, G, Margueron, R, Oda, H, Sarma, K, Sims, 3rd, R J, Son, J, Trojer, P, Reinberg, D

“…Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the…”
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The Multiple Facets of PRC2 Alterations in Cancers by Wassef, M., Margueron, R.

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The key to development: interpreting the histone code? by Margueron, Raphael, Trojer, Patrick, Reinberg, Danny

“…Developmental stages in multicellular organisms proceed according to a temporally and spatially precise pattern of gene expression. It has become evident that…”
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Steps toward understanding the inheritance of repressive methyl-lysine marks in histones by Reinberg, D, Chuikov, S, Farnham, P, Karachentsev, D, Kirmizis, A, Kuzmichev, A, Margueron, R, Nishioka, K, Preissner, T S, Sarma, K, Abate-Shen, C, Steward, R, Vaquero, A

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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27 by Kirmizis, Antonis, Bartley, Stephanie M, Kuzmichev, Andrei, Margueron, Raphael, Reinberg, Danny, Green, Roland, Farnham, Peggy J

“…Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity…”
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Topic: AS04-MDS Biology and Pathogenesis/AS04e-Spliceosome machinery: DNA REPLICATION STRESS DUE TO LOSS OF R-LOOPS IN MYELODYSPLASTIC SYNDROMES WITH SF3B1 MUTATION by Rombaut, D., Lefevre, C., Farhat, B., Bondu, S., Letessier, A., Lesieur-Pasquier, A., Castillo-Guzman, D., Leduc, M., Hartono, S., Chesnais, V., Mangione, R., Boussaid, I., Houy, A., Bouscary, D., Willems, L., Chapuis, N., Kosmider, O., Park, S., Raynaud, S., Cluzeau, T., Clappier, E., Fenaux, P., Ades, L., Margueron, R., Wassef, M., Alsafadi, S., Solary, E., Constantinou, A., Stern, M.-H., Palancade, B., Droin, N., Miotto, B., Chédin, F., Fontenay, M.

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Composition and Histone Substrates of Polycomb Repressive Group Complexes Change during Cellular Differentiation by Kuzmichev, Andrei, Margueron, Raphael, Vaquero, Alejandro, Preissner, Tanja S., Scher, Michael, Kirmizis, Antonis, Ouyang, Xuesong, Brockdorff, Neil, Abate-Shen, Cory, Farnham, Peggy, Reinberg, Danny, Roeder, Robert G.

“…Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to have a profound effect on gene…”
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Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines by Wassef, M., Luscan, A., Battistella, A., Le Corre, S., Li, H., Wallace, M.R., Vidaud, M., Margueron, R.

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Histone deacetylase inhibition and estrogen signalling in human breast cancer cells by Margueron, Raphaël, Duong, Vanessa, Castet, Audrey, Cavaillès, Vincent

“…Estrogens are steroid hormones, which act through specific nuclear estrogen receptors (ERα and ERβ) and are important regulators of breast cancer growth. These…”
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Transcriptional Regulation by the Repressor of Estrogen Receptor Activity via Recruitment of Histone Deacetylases by Kurtev, Vladislav, Margueron, Raphael, Kroboth, Karin, Ogris, Egon, Cavailles, Vincent, Seiser, Christian

“…Histone acetyltransferases and deacetylases are recruited by transcription factors and adapter proteins to regulate specific subsets of target genes. We were…”
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Ligands Differentially Modulate the Protein Interactions of the Human Estrogen Receptors α and β by Margeat, Emmanuel, Bourdoncle, Anne, Margueron, Raphael, Poujol, Nicolas, Cavaillès, Vincent, Royer, Catherine

“…The interactions of human estrogen receptor subtypes ERα and ERβ with DNA and a 210 amino acid residue fragment of the coactivator protein SRC-1 bearing three…”
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The Nuclear Receptor Coactivator PGC-1α Exhibits Modes of Interaction with the Estrogen Receptor Distinct From those of SRC-1 by Bourdoncle, Anne, Labesse, Gilles, Margueron, Raphaël, Castet, Audrey, Cavaillès, Vincent, Royer, Catherine A.

“…Estrogen receptor (ER) function is mediated by multi-domain co-regulator proteins. A fluorescently labelled fragment of the human PGC-1α co-regulator (residues…”
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