Search Results - "Margolles, Yago"
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Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance
Published in eLife (24-07-2024)“…Antimicrobial resistance (AMR) poses a significant threat to human health. Although vaccines have been developed to combat AMR, it has proven challenging to…”
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Selection of single domain antibodies from immune libraries displayed on the surface of E. coli cells with two β-domains of opposite topologies
Published in PloS one (23-09-2013)“…Screening of antibody (Ab) libraries by direct display on the surface of E. coli cells is hampered by the presence of the outer membrane (OM). In this work we…”
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Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron
Published in Frontiers in immunology (25-04-2022)“…The emergence of SARS-CoV-2 variants that escape from immune neutralization are challenging vaccines and antibodies developed to stop the COVID-19 pandemic…”
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ssDNA recombineering boosts in vivo evolution of nanobodies displayed on bacterial surfaces
Published in Communications biology (07-10-2021)“…ssDNA recombineering has been exploited to hyperdiversify genomically-encoded nanobodies displayed on the surface of Escherichia coli for originating new…”
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Development of anti-membrane type 1-matrix metalloproteinase nanobodies as immunoPET probes for triple negative breast cancer imaging
Published in Frontiers in medicine (24-11-2022)“…Triple-negative breast cancer (TNBC) is characterized by aggressiveness and high rates of metastasis. The identification of relevant biomarkers is crucial to…”
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6
Targeting plasmid-encoded proteins that contain immunoglobulin-like domains to combat antimicrobial resistance
Published in eLife (24-07-2024)“…Antimicrobial resistance (AMR) poses a significant threat to human health. Although vaccines have been developed to combat AMR, it has proven challenging to…”
Get full text
Journal Article -
7
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
Published in Scientific reports (08-02-2021)“…Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains…”
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Rapid and direct quantification of the SARS-CoV-2 virus with an ultrasensitive nanobody-based photonic nanosensor
Published in Sensors & diagnostics (16-09-2022)“…The coronavirus (CoV) disease 2019 (COVID-19) is expected to become endemic in the coming years, meaning that the worldwide society shall be prepared to…”
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Selection of Single Domain Antibodies from Immune Libraries Displayed on the Surface of E. coli Cells with Two beta -Domains of Opposite Topologies: e75126
Published in PloS one (01-09-2013)“…Screening of antibody (Ab) libraries by direct display on the surface of E. coli cells is hampered by the presence of the outer membrane (OM). In this work we…”
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Journal Article