Search Results - "Margolis, R"

Evolutionary Origins of cGAS-STING Signaling by Margolis, Shally R, Wilson, Stephen C, Vance, Russell E

“…Detection of foreign nucleic acids is an important strategy for innate immune recognition of pathogens. In vertebrates, pathogen-derived DNA is sensed in the…”
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Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila by Gonçalves, Augusto V, Margolis, Shally R, Quirino, Gustavo F S, Mascarenhas, Danielle P A, Rauch, Isabella, Nichols, Randilea D, Ansaldo, Eduard, Fontana, Mary F, Vance, Russell E, Zamboni, Dario S

“…Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4…”
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Evaluating the limits of solar photovoltaics (PV) in traditional electric power systems by Denholm, Paul, Margolis, Robert M.

“…In this work, we examine some of the limits to large-scale deployment of solar photovoltaics (PV) in traditional electric power systems. Specifically, we…”
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Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation by Chiang, C-H, Su, Y, Wen, Z, Yoritomo, N, Ross, C A, Margolis, R L, Song, H, Ming, G-l

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Evaluating the limits of solar photovoltaics (PV) in electric power systems utilizing energy storage and other enabling technologies by Denholm, Paul, Margolis, Robert M.

“…In this work, we evaluate technologies that will enable solar photovoltaics (PV) to overcome the limits of traditional electric power systems. We performed…”
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PdS receiver function evidence for crustal scale thrusting, relic subduction, and mafic underplating in the Trans-Hudson Orogen and Yavapai province by Thurner, S., Margolis, R., Levander, A., Niu, F.

“…The Trans-Hudson Orogen (THO) in the north central United States represents a major suturing event between the Wyoming and Superior Archean provinces. It is…”
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A wafer-based monocrystalline silicon photovoltaics road map: Utilizing known technology improvement opportunities for further reductions in manufacturing costs by Goodrich, Alan, Hacke, Peter, Wang, Qi, Sopori, Bhushan, Margolis, Robert, James, Ted L., Woodhouse, Michael

“…As an initial investigation into the current and potential economics of one of today's most widely deployed photovoltaic technologies, we have engaged in a…”
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Land-use requirements and the per-capita solar footprint for photovoltaic generation in the United States by Denholm, Paul, Margolis, Robert M.

“…In this report, we estimate the state-by-state per-capita “solar electric footprint” for the United States, defined as the land area required to supply all…”
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Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders by Ayhan, Y, Abazyan, B, Nomura, J, Kim, R, Ladenheim, B, Krasnova, I N, Sawa, A, Margolis, R L, Cadet, J L, Mori, S, Vogel, M W, Ross, C A, Pletnikov, M V

“…Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 ( DISC1 ) as risk factors for both schizophrenia and…”
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A comparison of nine scales to detect depression in Parkinson disease: Which scale to use? by WILLIAMS, J. R, HIRSCH, E. S, PONTONE, G, WEISS, H, RABINS, P, MARSH, L, ANDERSON, K, BUSH, A. L, GOLDSTEIN, S. R, GRILL, S, LEHMANN, S, LITTLE, J. T, MARGOLIS, R. L, PALANCI, J

“…The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties of 9 depression scales to provide…”
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Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease by van Bergen, J M G, Hua, J, Unschuld, P G, Lim, I A L, Jones, C K, Margolis, R L, Ross, C A, van Zijl, P C M, Li, X

“…In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported,…”
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Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues by Amoyel, Marc, Hillion, Kenzo-Hugo, Margolis, Shally R, Bach, Erika A

“…Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation is viewed as a passive process that depends on loss of access to…”
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Onset and rate of striatal atrophy in preclinical Huntington disease by AYLWARD, E. H, SPARKS, B. F, MARGOLIS, R. L, ROSS, C. A, FIELD, K. M, YALLAPRAGADA, V, SHPRITZ, B. D, ROSENBLATT, A, BRANDT, J, GOURLEY, L. M, LIANG, K, ZHOU, H

“…Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms. To determine when striatal atrophy begins,…”
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SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition by Kim, J A, Lee, J, Margolis, R L, Fotedar, R

“…Cell cycle controls ensure that DNA replication (S phase) follows mitosis resulting in two precise copies of the genome. A failure of the control mechanisms…”
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A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder by SACHS, N. A, SAWA, A, HOLMES, S. E, ROSS, C. A, DELISI, L. E, MARGOLIS, R. L

“…In a large Scottish pedigree, a balanced translocation t(1;11)(q42.1;q14.3) segregates with major mental illness, including schizophrenia, bipolar disorder,…”
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Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens by Morrison, Huntly M, Craft, Julia, Rivera-Lugo, Rafael, Johnson, Jeffery R, Golovkine, Guillaume R, Bell, Samantha L, Dodd, Claire E, Van Dis, Erik, Beatty, Wandy L, Margolis, Shally R, Repasy, Teresa, Shaker, Isaac, Lee, Angus Y, Vance, Russell E, Stanley, Sarah A, Watson, Robert O, Krogan, Nevan J, Portnoy, Daniel A, Penn, Bennett H, Cox, Jeffery S

“…Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic…”
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Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons by Ji, Daisy X, Witt, Kristen C, Kotov, Dmitri I, Margolis, Shally R, Louie, Alexander, Chevée, Victoria, Chen, Katherine J, Gaidt, Moritz M, Dhaliwal, Harmandeep S, Lee, Angus Y, Nishimura, Stephen L, Zamboni, Dario S, Kramnik, Igor, Portnoy, Daniel A, Darwin, K Heran, Vance, Russell E

“…Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important…”
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The association of CAG repeat length with clinical progression in huntington disease by ROSENBLATT, A, LIANG, K.-Y, ZHOU, H, ABBOTT, M. H, GOURLEY, L. M, MARGOLIS, R. L, BRANDT, J, ROSS, C. A

“…To determine whether the rate of clinical progression in Huntington disease (HD) is influenced by the size of the CAG expansion. The dataset consisted of 3,402…”
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The Neuronal Chondroitin Sulfate Proteoglycan Neurocan Binds to the Neural Cell Adhesion Molecules Ng-CAM/L1/NILE and N-CAM, and Inhibits Neuronal Adhesion and Neurite Outgrowth by Friedlander, David R., Milev, Peter, Karthikeyan, Laina, Margolis, Renée K., Margolis, Richard U., Grumet, Martin

“…We have previously shown that aggregation of microbeads coated with N-CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a chondroitin sulfate…”
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Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy by Williams, Madison C., Reker, Alexandra E., Margolis, Shally R., Liao, Jingqiu, Wiedmann, Martin, Rojas, Enrique R., Meeske, Alexander J.

“…Type VI CRISPR systems protect against phage infection using the RNA-guided nuclease Cas13 to recognize viral messenger RNA. Upon target recognition, Cas13…”
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