Search Results - "Margolin, L"

The reality of artificial viscosity by Margolin, L. G.

“…Artificial viscosity is used in the computer simulation of high Reynolds number flows and is one of the oldest numerical artifices. In this paper, I will…”
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Scale matters by Margolin, L. G.

“…The applicability of Navier-Stokes equations is limited to near-equilibrium flows in which the gradients of density, velocity and energy are small. Here I…”
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Artificial viscosity—then and now by Margolin, L. G., Lloyd-Ronning, N. M.

“…In this paper, we recount the history of artificial viscosity, beginning with its origin in previously unpublished and unavailable documents, continuing on to…”
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A modern concept of Lagrangian hydrodynamics by Margolin, L. G., Canfield, J. M.

“…We offer a modern interpretation of Lagrangian hydrodynamics as employed in Lagrangian simulations of compressible fluid flow. Our main result is to show that…”
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On the Convergence of the Cross-Entropy Method by Margolin, L.

“…The cross-entropy method is a relatively new method for combinatorial optimization. The idea of this method came from the simulation field and then was…”
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Second-order sign-preserving conservative interpolation (remapping) on general grids by Margolin, L.G., Shashkov, Mikhail

“…An accurate conservative interpolation (remapping) algorithm is an essential component of most arbitrary Lagrangian–Eulerian (ALE) methods. In this paper we…”
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Finite-scale equations for compressible fluid flow by Margolin, L.G.

“…Finite-scale equations (FSE) describe the evolution of finite volumes of fluid over time. We discuss the FSE for a one-dimensional compressible fluid, whose…”
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Modeling turbulent flow with implicit LES by Margolin, L. G., Rider, W. J., Grinstein, F. F.

“…Implicit large eddy simulation (ILES) is a methodology for modeling high Reynolds' number flows that combine computational efficiency and ease of…”
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Crystalline Monoclonal Antibodies for Subcutaneous Delivery by Yang, Mark X., Shenoy, Bhami, Disttler, Matthew, Patel, Reena, McGrath, Margaret, Pechenov, Sergey, Margolin, Alexey L.

“…Therapeutic applications for mAbs have increased dramatically in recent years, but the large quantities required for clinical efficacy have limited the options…”
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Finite volume methods and the equations of finite scale: A mimetic approach by Margolin, L. G., Shashkov, M.

“…After introducing the general concept of mimetic differencing, we focus on two specific methodologies, nonoscillatory methods and finite volume approximations…”
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Protein Crystals as Novel Catalytic Materials by Margolin, Alexey L., Navia, Manuel A.

“…In this era of molecular biology, protein crystallization is often considered to be a necessary first step in obtaining structural information through X‐ray…”
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On balanced approximations for time integration of multiple time scale systems by Knoll, D.A., Chacon, L., Margolin, L.G., Mousseau, V.A.

“…The effect of various numerical approximations used to solve linear and nonlinear problems with multiple time scales is studied in the framework of modified…”
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Stability of crystalline proteins by Shenoy, Bhami, Wang, Yi, Shan, Weizhong, Margolin, Alexey L.

“…By using two model proteins, glucose oxidase and lipase, we demonstrate that dry crystalline formulations are significantly more stable than their amorphous…”
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Finite scale theory: Predicting nature’s shocks by Margolin, L.G., Plesko, C.S., Reisner, J.M.

“…In this paper, we describe a continuum model that accurately reproduces the experimentally measured structure of physical shocks in a perfect gas. We begin by…”
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Remapping, recovery and repair on a staggered grid by Margolin, L.G., Shashkov, Mikhail

“…An accurate remapping algorithm is an essential component of many arbitrary Lagrangian–Eulerian (ALE) methods. In previous work, we have described a local…”
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The design and construction of implicit LES models by Margolin, L. G., Rider, W. J.

“…We offer preliminary thoughts on the design of a modified equation and the construction of a corresponding numerical algorithm, which may be intended for use…”
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Entropy in self-similar shock profiles by Margolin, L.G., Reisner, J.M., Jordan, P.M.

“…In this paper, we study the structure of a gaseous shock, and in particular the distribution of entropy within, in both a thermodynamics and a statistical…”
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Fully compressible solutions for early stage Richtmyer–Meshkov instability by Margolin, L.G., Reisner, J.M.

“…•We study the early stages of Richtmyer-Meshkov instability.•We perform 2D simulations based on fully compressible viscous fluid dynamics.•We construct a 1D…”
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Protein crystals for the delivery of biopharmaceuticals by Basu, Sujit K, Govardhan, Chandrika P, Jung, Chu W, Margolin, Alexey L

“…The year 2002 marked the 20th anniversary of the first successful product of modern biotechnology, the regulatory approval of recombinant insulin for…”
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Novel long-acting crystal formulation of human growth hormone by Govardhan, Chandrika, Khalaf, Nazer, Jung, Chu W, Simeone, Ben, Higbie, Amy, Qu, Susan, Chemmalil, Letha, Pechenov, Sergey, Basu, Sujit K, Margolin, Alexey L

“…The aim of the study is to solve a significant challenge of extending the half-life of therapeutic proteins using crystalline biopharmaceuticals and without…”
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