Search Results - "Margol, Ashley S."

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas by Bayliss, Jill, Mukherjee, Piali, Lu, Chao, Jain, Siddhant U, Chung, Chan, Martinez, Daniel, Sabari, Benjamin, Margol, Ashley S, Panwalkar, Pooja, Parolia, Abhijit, Pekmezci, Melike, McEachin, Richard C, Cieslik, Marcin, Tamrazi, Benita, Garcia, Benjamin A, La Rocca, Gaspare, Santi, Mariarita, Lewis, Peter W, Hawkins, Cynthia, Melnick, Ari, David Allis, C, Thompson, Craig B, Chinnaiyan, Arul M, Judkins, Alexander R, Venneti, Sriram

“…Childhood posterior fossa (PF) ependymomas cause substantial morbidity and mortality. These tumors lack recurrent genetic mutations, but a subset of these…”
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Tumor-associated macrophages in SHH subgroup of medulloblastomas by Margol, Ashley S, Robison, Nathan J, Gnanachandran, Janahan, Hung, Long T, Kennedy, Rebekah J, Vali, Marzieh, Dhall, Girish, Finlay, Jonathan L, Erdreich-Epstein, Anat, Krieger, Mark D, Drissi, Rachid, Fouladi, Maryam, Gilles, Floyd H, Judkins, Alexander R, Sposto, Richard, Asgharzadeh, Shahab

“…Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce…”
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Pathology and diagnosis of SMARCB1-deficient tumors by Margol, Ashley S, Judkins, Alexander R

“…Malignant rhabdoid tumor (MRT) can occur in the kidney, central nervous system, or extracranial/extrarenal locations and is characterized by alterations in the…”
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Sustained response of three pediatric BRAFV600E mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy by Toll, Stephanie A., Tran, Hung N., Cotter, Jennifer, Judkins, Alexander R., Tamrazi, Benita, Biegel, Jaclyn A., Dhall, Girish, Robison, Nathan J., Waters, Kaaren, Patel, Palak, Cooper, Robert, Margol, Ashley S.

“…Outcomes for children with high-grade gliomas (HGG) remain dismal despite aggressive treatment strategies. The use of targeted therapy for BRAFV600E mutated…”
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Central diabetes insipidus: A rare unreported side effect of temozolomide in pediatrics by Kuo, Christopher, Foon, Dione, Waters, Kaaren, Cheung, Clement, Margol, Ashley S.

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Use of External Control Cohorts in Pediatric Brain Tumor Clinical Trials by Margol, Ashley S, Molinaro, Annette M, Onar-Thomas, Arzu, Resnick, Adam, Hanson, Derek, Kieran, Mark, Mishra-Kalyani, Pallavi, Rivera, Donna, Barone, Amy, Arons, David, Meehan, Clair, Prados, Michael

“…Why, when, and how to consider external control cohorts in pediatric brain tumor clinical trials…”
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Pediatric Central Nervous System Embryonal Tumors: Presentation, Diagnosis, Therapeutic Strategies, and Survivorship—A Review by Ronsley, Rebecca, Cole, Bonnie, Ketterl, Tyler, Wright, Jason, Ermoian, Ralph, Hoffman, Lindsey M., Margol, Ashley S., Leary, Sarah E.S.

“…Central nervous system (CNS) embryonal tumors represent a diverse group of neoplasms and have a peak incidence in early childhood. These tumors can be located…”
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Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma by Rosenberg, Tom, Yeo, Kee Kiat, Mauguen, Audrey, Alexandrescu, Sanda, Prabhu, Sanjay P, Tsai, Jessica W, Malinowski, Seth, Joshirao, Mrinal, Parikh, Karishma, Farouk Sait, Sameer, Rosenblum, Marc K, Benhamida, Jamal K, Michaiel, George, Tran, Hung N, Dahiya, Sonika, Kachurak, Kara, Friedman, Gregory K, Krystal, Julie I, Huang, Michael A, Margol, Ashley S, Wright, Karen D, Aguilera, Dolly, MacDonald, Tobey J, Chi, Susan N, Karajannis, Matthias A

“…The prognosis for patients with pediatric high-grade glioma (pHGG) is poor despite aggressive multimodal therapy. Objective responses to targeted therapy with…”
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MR multitasking‐based dynamic imaging for cerebrovascular evaluation ( MT‐DICE ): Simultaneous quantification of permeability and leakage‐insensitive perfusion by dynamic T1/T2 mapping by Hu, Zhehao, Christodoulou, Anthony G., Wang, Nan, Xie, Yibin, Shiroishi, Mark S., Yang, Wensha, Zada, Gabriel, Chow, Frances E., Margol, Ashley S., Tamrazi, Benita, Chang, Eric L., Li, Debiao, Fan, Zhaoyang

“…Purpose To develop an MR multitasking‐based dynamic imaging for cerebrovascular evaluation (MT‐DICE) technique for simultaneous quantification of permeability…”
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Clinical and neuropsychological outcome of pediatric non‐midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience by Yeo, Kee Kiat, Kayser, Kimberly, Margol, Ashley S., Wong, Kenneth K., Robison, Nathan, Finlay, Jonathan, Dhall, Girish

“…Background Germ cell tumors (GCT) arising from non‐midline structures (basal ganglia, thalamus, and posterior fossa) are rare. Although patients with midline…”
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A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children’s Oncology Group by Margol, Ashley S., Yeo, Kee Kiat, Xia, Caihong, Onar, Arzu, Robison, Nathan J., Freyer, David R., Dhall, Girish

“…Background For several types of cancer, biological differences and outcome disparities have been documented in adolescents/young adults (AYAs, 15–39 years old)…”
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Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens by Yeo, Kee Kiat, Margol, Ashley S., Kennedy, Rebekah J., Hung, Long, Robison, Nathan J., Dhall, Girish, Asgharzadeh, Shahab

“…Purpose Irradiation-avoiding strategies have been used with relative success in the treatment of infants and young children with medulloblastoma. While…”
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Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy by Blüml, Stefan, Margol, Ashley S, Sposto, Richard, Kennedy, Rebekah J, Robison, Nathan J, Vali, Marzieh, Hung, Long T, Muthugounder, Sakunthala, Finlay, Jonathan L, Erdreich-Epstein, Anat, Gilles, Floyd H, Judkins, Alexander R, Krieger, Mark D, Dhall, Girish, Nelson, Marvin D, Asgharzadeh, Shahab

“…Medulloblastomas in children can be categorized into 4 molecular subgroups with differing clinical characteristics, such that subgroup determination aids in…”
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A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients by Lim-Fat, Mary Jane, Cotter, Jennifer A, Touat, Mehdi, Vogelzang, Jayne, Sousa, Cecilia, Pisano, Will, Geduldig, Jack, Bhave, Varun, Driver, Joseph, Kao, Pei-Chi, McGovern, Alana, Ma, Clement, Margol, Ashley S, Cole, Kristina, Smith, Amy, Goldman, Stewart, Kaneva, Kristiyana, Truong, Ai Lien, Nazemi, Kellie J, Wood, Matthew D, Wright, Karen D, London, Wendy B, Warren, Katherine E, Wen, Patrick Y, Bi, Wenya Linda, Alexandrescu, Sanda, Reardon, David A, Ligon, Keith L, Yeo, Kee Kiat

“…The frequency and significance of IDH mutations in glioma across age groups is incompletely understood. We performed a multi-center retrospective…”
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Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics by Yeo, Kee Kiat, Alexandrescu, Sanda, Cotter, Jennifer A, Vogelzang, Jayne, Bhave, Varun, Li, Marilyn M, Ji, Jianling, Benhamida, Jamal K, Rosenblum, Marc K, Bale, Tejus A, Bouvier, Nancy, Kaneva, Kristiyana, Rosenberg, Tom, Lim-Fat, Mary Jane, Ghosh, Hia, Martinez, Migdalia, Aguilera, Dolly, Smith, Amy, Goldman, Stewart, Diamond, Eli L, Gavrilovic, Igor, MacDonald, Tobey J, Wood, Matthew D, Nazemi, Kellie J, Truong, AiLien, Cluster, Andrew, Ligon, Keith L, Cole, Kristina, Bi, Wenya Linda, Margol, Ashley S, Karajannis, Matthias A, Wright, Karen D

“…The incidence and biology of IDH1/2 mutations in pediatric gliomas are unclear. Notably, current treatment approaches by pediatric and adult providers vary…”
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Addendum: Sustained response of three pediatric BRAFV600E mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy by Toll, Stephanie A, Tran, Hung N, Cotter, Jennifer, Judkins, Alexander R, Tamrazi, Benita, Biegel, Jaclyn A, Dhall, Girish, Robison, Nathan J, Waters, Kaaren, Patel, Palak, Cooper, Robert, Margol, Ashley S

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Multi‐institutional analysis of central nervous system germ cell tumors in patients with Down syndrome by Harris, Micah K., Graham, Richard T., Cappellano, Andréa M., Margol, Ashley S., Michaiel, George, Crawford, John R., Ioakeim‐Ioannidou, Myrsini, Stanek, Joseph R., Liu, Kevin X., MacDonald, Shannon M., Abdelbaki, Mohamed S.

“…Purpose Primary germ cell tumors (GCTs) are the most common central nervous system (CNS) neoplasm in patients with Down syndrome (DS). However, a standard of…”
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Phase I trial of dasatinib, lenalidomide, and temozolomide in children with relapsed or refractory central nervous system tumors by Robison, Nathan J., Yeo, Kee Kiat, Berliner, Adrian P., Malvar, Jemily, Sheard, Michael A., Margol, Ashley S., Seeger, Robert C., Rushing, Teresa, Finlay, Jonathan L., Sposto, Richard, Dhall, Girish

“…Single agent studies targeting the tumor microenvironment in central nervous system (CNS) tumors have largely been disappointing. Combination therapies…”
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Effective re-induction regimen for children with recurrent medulloblastoma by O’Halloran, Katrina, Phadnis, Sheetal, Friedman, Gregory K, Metrock, Katie, Davidson, Tom B, Robison, Nathan J, Tamrazi, Benita, Cotter, Jennifer A, Dhall, Girish, Margol, Ashley S

“…Abstract Background There is no standard treatment for the recurrence of medulloblastoma, the most common malignant childhood brain tumor, and prognosis…”
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A genome-wide association study on medulloblastoma by Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice

“…Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants…”
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