Search Results - "Margaret C. M. Smith"

A phage protein that binds φC31 integrase to switch its directionality by Khaleel, Thanafez, Younger, Ellen, McEwan, Andrew R., Varghese, Anpu S., Smith, Margaret C. M.

“…Summary The serine integrase, Int, from the Streptomyces phage φC31 mediates the integration and excision of the phage genome into and out of the host…”
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Evolutionary Relationships among Actinophages and a Putative Adaptation for Growth in Streptomyces spp by Smith, Margaret C. M, Hendrix, Roger W, Dedrick, Rebekah, Mitchell, Kaitlin, Ko, Ching-Chung, Russell, Daniel, Bell, Emma, Gregory, Matthew, Bibb, Maureen J, Pethick, Florence, Jacobs-Sera, Deborah, Herron, Paul, Buttner, Mark J, Hatfull, Graham F

“…The genome sequences of eight Streptomyces phages are presented, four of which were isolated for this study. Phages R4, TG1, ϕHau3, and SV1 were isolated…”
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An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides by Houssen, Wael E., Bent, Andrew F., McEwan, Andrew R., Pieiller, Nathalie, Tabudravu, Jioji, Koehnke, Jesko, Mann, Greg, Adaba, Rosemary I., Thomas, Louise, Hawas, Usama W., Liu, Huanting, Schwarz-Linek, Ulrich, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel

“…Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new…”
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Integrating vectors for genetic studies in the rare Actinomycete Amycolatopsis marina by Gao, Hong, Murugesan, Buvani, Hoßbach, Janina, Evans, Stephanie K, Stark, W Marshall, Smith, Margaret C M

“…Few natural product pathways from rare Actinomycetes have been studied due to the difficulty in applying molecular approaches in these genetically intractable…”
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Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis by Fayed, Bahgat, Ashford, David A, Hashem, Amal M, Amin, Magdy A, El Gazayerly, Omaima N, Gregory, Matthew A, Smith, Margaret C M

“…Bacteria in the genus Streptomyces and its close relatives are prolific producers of secondary metabolites with antibiotic activity. Genome sequencing of these…”
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A flexible mathematical model platform for studying branching networks: experimentally validated using the model actinomycete, Streptomyces coelicolor by Nieminen, Leena, Webb, Steven, Smith, Margaret C M, Hoskisson, Paul A

“…Branching networks are ubiquitous in nature and their growth often responds to environmental cues dynamically. Using the antibiotic-producing soil bacterium…”
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The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides by Houssen, Wael E., Koehnke, Jesko, Zollman, David, Vendome, Jeremie, Raab, Andrea, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel

“…Cyanobactins, including patellamides, are a group of cyanobacterial post‐translationally modified ribosomal cyclic peptides. The final product should in theory…”
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Use of an inducible promoter for antibiotic production in a heterologous host by Dangel, Volker, Westrich, Lucia, Smith, Margaret C. M, Heide, Lutz, Gust, Bertolt

“…The biosynthetic gene cluster of the aminocoumarin antibiotic novobiocin comprises 20 coding sequences. Sixteen of them code for essential enzymes for…”
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Cross-resistance is modular in bacteria-phage interactions by Wright, Rosanna C T, Friman, Ville-Petri, Smith, Margaret C M, Brockhurst, Michael A

“…Phages shape the structure of natural bacterial communities and can be effective therapeutic agents. Bacterial resistance to phage infection, however, limits…”
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Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure by Wright, Rosanna C T, Friman, Ville-Petri, Smith, Margaret C M, Brockhurst, Michael A

“…Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of…”
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Hypervariation and phase variation in the bacteriophage ‘resistome’ by Hoskisson, Paul A, Smith, Margaret CM

“…Most bacteria encode proteins for defence against infection by bacteriophages. The mechanisms that bring about phage defence are extremely diverse, suggesting…”
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Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor by Martín, Juan F., Santos-Beneit, Fernando, Rodríguez-García, Antonio, Sola-Landa, Alberto, Smith, Margaret C. M., Ellingsen, Trond E., Nieselt, Kay, Burroughs, Nigel J., Wellington, Ellizabeth M. H.

“…Phosphate controls the biosynthesis of many classes of secondary metabolites that belong to different biosynthetic groups, indicating that phosphate control is…”
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Genome Sequence of the Fleming Strain of Micrococcus luteus, a Simple Free-Living Actinobacterium by Young, Michael, Artsatbanov, Vladislav, Beller, Harry R, Chandra, Govind, Chater, Keith F, Dover, Lynn G, Goh, Ee-Been, Kahan, Tamar, Kaprelyants, Arseny S, Kyrpides, Nikos, Lapidus, Alla, Lowry, Stephen R, Lykidis, Athanasios, Mahillon, Jacques, Markowitz, Victor, Mavromatis, Konstantinos, Mukamolova, Galina V, Oren, Aharon, Rokem, J Stefan, Smith, Margaret C M, Young, Danielle I, Greenblatt, Charles L

“…OA  Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination by Colloms, Sean D, Merrick, Christine A, Olorunniji, Femi J, Stark, W Marshall, Smith, Margaret C M, Osbourn, Anne, Keasling, Jay D, Rosser, Susan J

“…Synthetic biology requires effective methods to assemble DNA parts into devices and to modify these devices once made. Here we demonstrate a convenient rapid…”
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The Conjugative Transposon Tn5397 Has a Strong Preference for Integration into Its Clostridium difficile Target Site by Wang, Hongmei, Smith, Margaret C M, Mullany, Peter

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The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain by Koehnke, Jesko, Bent, Andrew, Houssen, Wael E, Zollman, David, Morawitz, Falk, Shirran, Sally, Vendome, Jeremie, Nneoyiegbe, Ada F, Trembleau, Laurent, Botting, Catherine H, Smith, Margaret C M, Jaspars, Marcel, Naismith, James H

“…The subtilisin-like domain of PatG can catalyze the macrocyclization of linear peptide. The crystal structure of the PatG macrocyclase domain, along with…”
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The mechanism of ϕC31 integrase directionality: experimental analysis and computational modelling by Pokhilko, Alexandra, Zhao, Jia, Ebenhöh, Oliver, Smith, Margaret C M, Stark, W Marshall, Colloms, Sean D

“…Serine integrases, DNA site-specific recombinases used by bacteriophages for integration and excision of their DNA to and from their host genomes, are…”
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Characterization of the Streptomyces coelicolor Glycoproteome Reveals Glycoproteins Important for Cell Wall Biogenesis by Keenan, Tessa, Dowle, Adam, Bates, Rachel, Smith, Margaret C M

“…The physiological role of protein O-glycosylation in prokaryotes is poorly understood due to our limited knowledge of the extent of their glycoproteomes. In ,…”
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Gated rotation mechanism of site-specific recombination by ΦC31 integrase by Olorunniji, Femi J., Buck, Dorothy E., Colloms, Sean D., McEwan, Andrew R., Smith, Margaret C. M., Stark, W. Marshall, Rosser, Susan J.

“…Integrases, such as that of the Streptomyces temperate bacteriophage ΦC31, promote site-specific recombination between DNA sequences in the bacteriophage and…”
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Complete genome sequence of ‘Mycobacterium neoaurum’ NRRL B-3805, an androstenedione (AD) producer for industrial biotransformation of sterols by Rodríguez‐García, Antonio, Fernández‐Alegre, Estela, Morales, Alejandro, Sola‐Landa, Alberto, Lorraine, Jess, Macdonald, Sandy, Dovbnya, Dmitry, Smith, Margaret C.M., Donova, Marina, Barreiro, Carlos

“…•Genome sequence of the 4-androstene-3,17-dione (AD) producer strain ‘M. neoaurum’ NRRL B-3805 (formerly Mycobacterium sp. NRRL B-3805).•Sequence of B-3805 was…”
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