Search Results - "Marfe, Gabriella"

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction by Marfe, Gabriella, Tafani, Marco, Indelicato, Manuela, Sinibaldi-Salimei, Paola, Reali, Valentina, Pucci, Bruna, Fini, Massimo, Russo, Matteo Antonio

“…Kaempferol (3,4′,5,7‐tetrahydroxyflavone) is a flavonoid with anti‐ and pro‐oxidant activity present in various natural sources. Kaempferol has been shown to…”
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Sphingosine kinases signalling in carcinogenesis by Marfe, Gabriella, Mirone, Giovanna, Shukla, Arvind, Di Stefano, Carla

“…Sphingosine kinases (Sphk1 and 2) regulate the prodution of sphingosine-1-phosphate (S1P), that is key molecule in cancer development. SphK1, which is commonly…”
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Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells by Marfe, Gabriella, Di Stefano, Carla, Gambacurta, Alessandra, Ottone, Tiziana, Martini, Valentina, Abruzzese, Elisabetta, Mologni, Luca, Sinibaldi-Salimei, Paola, de Fabritis, Paolo, Gambacorti-Passerini, Carlo, Amadori, Sergio, Birge, Raymond B

“…Objective As a better understanding of the molecular basis of carcinogenesis has emerged, oncogene-specific cell-signaling pathways have been successfully…”
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Bypass mechanisms of resistance to tyrosine kinase inhibition in chronic myelogenous leukaemia by Marfe, Gabriella, Di Stefano, Carla

“…Chronic myeloid leukaemia (CML) is a disease induced by the BCR-ABL oncogene. Tyrosine kinase inhibitors (TKIs) were introduced in the late 1990s and have…”
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Pyrrolo[1,2‐b][1,2,5]benzothiadiazepines (PBTDs) exert their anti‐proliferative activity by interfering with Akt–mTOR signaling and bax:bcl‐2 ratio modulation in cells from chronic myeloid leukemic patients by Di Stefano, Carla, Marfe, Gabriella, Trawinska, Malgorzata Monika, Sinibaldi‐Salimei, Paola, Silvestri, Romano, Amadori, Sergio, Abruzzese, Elisabetta

“…In our study we found that pyrrolo[1,2‐b][1,2,5]benzothiadiazepines (PBTDs) mediated apoptosis in primary leukemia cells from 27 chronic myelogenous leukemia…”
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The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners by Marfe, Gabriella, Tafani, Marco, Pucci, Bruna, Di Stefano, Carla, Indelicato, Manuela, Andreoli, Angela, Russo, Matteo Antonio, Sinibaldi-Salimei, Paola, Manzi, Vincenzo

“…A large body of evidence shows that a single bout of strenuous exercise induces oxidative stress in circulating human lymphocytes leading to lipid…”
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In vitro anti-leukaemia activity of pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) by Marfe, Gabriella, Di Stefano, Carla

“…Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by unregulated growth of myeloid leukemia cells in the bone marrow and…”
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Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models by ROSA, Roberta, MARCIANO, Roberta, ZANNETTI, Antonella, GRECO, Adelaide, DE STEFANO, Alfonso, CARLOMAGNO, Chiara, VENEZIANI, Bianca Maria, TRONCONE, Giancarlo, DE PLACIDO, Sabino, BIANCO, Roberto, MALAPELLE, Umberto, FORMISANO, Luigi, NAPPI, Lucia, D'AMATO, Claudia, D'AMATO, Valentina, DAMIANO, Vincenzo, MARFE, Gabriella, DEL VECCHIO, Silvana

“…Although the anti-EGF receptor (EGFR) monoclonal antibody cetuximab is an effective strategy in colorectal cancer therapy, its clinical use is limited by…”
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The evidence of toxic wastes dumping in Campania, Italy by Marfe, Gabriella, Di Stefano, Carla

“…Abstract The region of Campania (particularly Naples and Caserta) were subjected to extensive illegal dumping operations of toxic and radioactive wastes since…”
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Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type II-induced apoptosis by Marfè, Gabriella, Tafani, Marco, Fiorito, Filomena, Pagnini, Ugo, Iovane, Giuseppe, De Martino, Luisa

“…n our previous study, we have shown that canine coronavirus type II (CCoV-II) activates both extrinsic and intrinsic apoptotic pathway in a canine fibrosarcoma…”
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Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells by Mirone, Giovanna, Perna, Stefania, Shukla, Arvind, Marfe, Gabriella

“…Regorafenib, an oral small‐molecule multi kinase inhibitor, is able to block Vascular Endothelial Growth Factor Receptors (VEGFR‐1, 2, and 3), Platelet‐Derived…”
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Pyrrolo[1,2-B][1,2,5] benzodiazepines (PBTDs) Compounds Induce Apoptosis in Chronic Myeloid Leukaemia Cells from Patients at Onset, Imatinib and Second Generation TK Inhibitors (Dasatinib, Nilotinib) Resistant by Abruzzese, Elisabetta, Marfe', Gabriella, Di Stefano, Carla, Trawinska, Malgorzata M., Russo, Matteo A., Silvestri, Romano, Poeta, Giovanni Del, Martinelli, Giovanni, Soverini, Simona, de Fabritiis, Paolo, Amadori, Sergio, Salimei, Paola Sinibaldi

“…CML is a clonal myeloproliferative disease in which Bcr-Abl deregulated tyrosine kinase (TK) activity impairs blood cells homeostasis leading to altered…”
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PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells by Marfe, Gabriella, Di Stefano, Carla, Silvestri, Romano, Abruzzese, Elisabetta, Catalano, Gianfranco, Di Renzo, Livia, Filomeni, Giuseppe, Giorda, Ezio, La Regina, Giuseppe, Morgante, Emanuela, Ciriolo, Maria Rosa, Russo, Matteo Antonio, Amadori, Sergio, Sinibaldi-Salimei, Paola

“…The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES…”
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Effectiveness of COVID‑19 vaccines and their challenges (Review) by Marfe, Gabriella, Perna, Stefania, Shukla, Arvind Kumar

“…At the end of 2019, a new disease recognized such as severe acute respiratory syndrome (SARS), was reported in Wuhan, China. This disease was caused by an…”
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Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs):  A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant by Silvestri, Romano, Marfè, Gabriella, Artico, Marino, La Regina, Giuseppe, Lavecchia, Antonio, Novellino, Ettore, Morgante, Emanuela, Di Stefano, Carla, Catalano, Gianfranco, Filomeni, Giuseppe, Abruzzese, Elisabetta, Ciriolo, Maria Rosa, Russo, Matteo Antonio, Amadori, Sergio, Cirilli, Roberto, La Torre, Francesco, Salimei, Paola Sinibaldi

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Signaling mechanisms of resistance to EGFR- and Anti-Angiogenic Inhibitors cancer by Mirone, Giovanna, Shukla, Arvind, Marfe, Gabriella

“…Abstract Colorectal cancer is among four most common malignancies and the second leading cause of cancer death in the western world. Epidermal Growth Factor…”
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Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis by De Martino, Luisa, Marfé, Gabriella, Longo, Mariangela, Fiorito, Filomena, Montagnaro, Serena, Iovane, Valentina, Decaro, Nicola, Pagnini, Ugo

“…A previous study demonstrated that infection of a canine fibrosarcoma cell line (A-72 cells) by canine coronavirus (CCoV) resulted in apoptosis ( Ruggieri et…”
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Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB by Tafani, Marco, Schito, Luana, Pellegrini, Laura, Villanova, Lidia, Marfe, Gabriella, Anwar, Tahira, Rosa, Roberta, Indelicato, Manuela, Fini, Massimo, Pucci, Bruna, Russo, Matteo A.

“…The role of hypoxia in regulating tumor progression is still controversial. Here, we demonstrate that, similarly to what previously observed by us in human…”
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Modulation of telomerase activity, bTERT and c-Myc induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin during Bovine Herpesvirus 1 infection in MDBK cells by Fiorito, Filomena, Cantiello, Antonietta, Granato, Giovanna Elvira, Marfè, Gabriella, Ciarcia, Roberto, Florio, Salvatore, Pagnini, Ugo, De Martino, Luisa, Iovane, Giuseppe

“…•TCDD anticipates BHV-1 induced apoptosis.•TCDD anticipates down-regulation of telomerase activity during BHV-1 infection in bovine cells (MDBK).•TCDD…”
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The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review) by DI STEFANO, CARLA, MIRONE, GIOVANNA, PERNA, STEFANIA, MARFE, GABRIELLA

“…Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal…”
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