Blood group factor and HLA-related epilepsy among the Armenian population

A study was made of the distribution of antigens of the isoserological systems ABO, Rh-Hr, MNSs, Duffy, Lutheran, Kidd, Kell-Chellano, P and Lewis in 192 epileptics++ in the Armenian community. It was found that the SS phenotype was significantly positively associated with epilepsy, whereas negative...

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Bibliographic Details
Published in:	Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) Vol. 90; no. 9; p. 85
Main Authors:	Darbinian, V Zh, Nersisian, V M, Musazlian, N O, Maretirosian, I G, Akopian, L P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1990
Subjects:	Armenia Blood Group Antigens - genetics Disease Susceptibility Epilepsy - blood Epilepsy - etiology Epilepsy - genetics Epilepsy - immunology Erythrocytes - immunology Genetic Markers - genetics Genetic Markers - immunology Haplotypes - genetics HLA-B27 Antigen - genetics HLA-DR3 Antigen - genetics Humans Phenotype Armenia
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Summary:	A study was made of the distribution of antigens of the isoserological systems ABO, Rh-Hr, MNSs, Duffy, Lutheran, Kidd, Kell-Chellano, P and Lewis in 192 epileptics++ in the Armenian community. It was found that the SS phenotype was significantly positively associated with epilepsy, whereas negative relations were established with the SS and AB phenotypes. The remaining group blood markers cannot serve markers of epilepsy in the Armenian community. The segregation familial analysis demonstrated as well that the MNSs system is not related genetically to the HLA system and the gene of "predisposition" to epilepsy, coupled in the Armenian community with HLA-B27 (cross-B27) and HLA-DR3 antigens.
ISSN:	0044-4588