Search Results - "Maresh, Marianne E."

The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders by Zerfas, Breanna L, Maresh, Marianne E, Trader, Darci J

“…The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed when cells are stressed or receive an inflammatory signal. The primary role of…”
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Approaches to Evaluate the Impact of a Small‐Molecule Binder to a Noncatalytic Site of the Proteasome by Tian, Wenzhi, Maresh, Marianne E., Trader, Darci J.

“…Proteasome activity is crucial for cell survival and proliferation. In recent years, small molecules have been discovered that can affect the catalytic…”
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A Yeast Chronological Lifespan Assay to Assess Activity of Proteasome Stimulators by Maresh, Marianne E., Chen, Panyue, Hazbun, Tony R., Trader, Darci J.

“…Aging is characterized by changes in several cellular processes, including dysregulation of proteostasis. Current research has shown long‐lived rodents display…”
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Discovery and Development of Cyclic Peptide Proteasome Stimulators by Nelson, Samantha, Harris, Timothy J., Muli, Christine S., Maresh, Marianne E., Baker, Braden, Smith, Chloe, Neumann, Chris, Trader, Darci J., Parkinson, Elizabeth I.

“…The proteasome degrades proteins, which is essential for cellular homeostasis. Ubiquitin independent proteolysis degrades highly disordered and misfolded…”
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Solid‐Phase Synthesis and Application of a Clickable Version of Epoxomicin for Proteasome Activity Analysis by Salazar‐Chaparro, Andres F., Halder, Saayak, Maresh, Marianne E., Trader, Darci J.

“…Degradation of proteins by the proteasome is an essential cellular process and one that many wish to study in a variety of disease types. There are…”
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Development of a Method To Prioritize Protein–Ligand Pairs on Beads Using Protein Conjugated to a Near-IR Dye by Maresh, Marianne E, Trader, Darci J

“…The development of techniques to screen one-bead–one-compound (OBOC) libraries remains a critical step in identifying small molecules that bind target…”
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Identification of a covalent binder to the oncoprotein gankyrin using a NIR-Based OBOC screening method by Maresh, Marianne E, Zerfas, Breanna L, Wuthrich, Brice S, Trader, Darci J

“…Despite huge advancements in the process of synthesizing small molecules as part of one-bead-one-compound (OBOC) libraries, progress lags in the ability to…”
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Methods for the discovery of small molecules to monitor and perturb the activity of the human proteasome by Maresh, Marianne E, Salazar-Chaparro, Andres F, Trader, Darci J

“…Regulating protein production and degradation is critical to maintaining cellular homeostasis. The proteasome is a key player in keeping proteins at the proper…”
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Approaches to Evaluate the Impact of a Small Molecule Binder to a Non-catalytic Site of the Proteasome by Tian, Wenzhi, Maresh, Marianne E., Trader, Darci J.

“…Proteasome activity is crucial for cell survival and proliferation. In recent years, small molecules have been discovered that can affect the catalytic…”
Get full text