Search Results - "Maresca, Thomas J"

Direct observation of branching MT nucleation in living animal cells by Verma, Vikash, Maresca, Thomas J

“…Centrosome-mediated microtubule (MT) nucleation has been well characterized; however, numerous noncentrosomal MT nucleation mechanisms exist. The branching MT…”
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Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway by Ye, Anna A., Deretic, Jovana, Hoel, Christopher M., Hinman, Albert W., Cimini, Daniela, Welburn, Julie P., Maresca, Thomas J.

“…Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from opposing spindle poles, is the configuration that best ensures equal…”
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Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis by Verma, Vikash, Maresca, Thomas J

“…Microtubules (MTs) are essential for cleavage furrow positioning during cytokinesis, but the mechanisms by which MT-derived signals spatially define regions of…”
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Chromosome biorientation produces hundreds of piconewtons at a metazoan kinetochore by Ye, Anna A., Cane, Stuart, Maresca, Thomas J.

“…High-fidelity transmission of the genome through cell division requires that all sister kinetochores bind to dynamic microtubules (MTs) from opposite spindle…”
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FRET-based sensor for CaMKII activity (FRESCA): A useful tool for assessing CaMKII activity in response to Ca2+ oscillations in live cells by Ardestani, Goli, West, Megan C., Maresca, Thomas J., Fissore, Rafael A., Stratton, Margaret M.

“…Ca2+ oscillations and consequent Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation are required for embryogenesis, as well as neuronal,…”
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The whole is greater than the sum of its parts: at the intersection of order, disorder, and kinetochore function by Audett, Margaux R, Maresca, Thomas J

“…The kinetochore (KT) field has matured tremendously since Earnshaw first identified CENP-A, CENP-B, and CENP-C [1,2]. In the past 35 years, the accumulation of…”
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Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes by Drpic, Danica, Pereira, António J., Barisic, Marin, Maresca, Thomas J., Maiato, Helder

“…Chromosome bi-orientation occurs after conversion of initial lateral attachments between kinetochores and spindle microtubules into stable end-on attachments…”
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Elevated polar ejection forces stabilize kinetochore-microtubule attachments by Cane, Stuart, Ye, Anna A, Luks-Morgan, Sasha J, Maresca, Thomas J

“…Chromosome biorientation promotes congression and generates tension that stabilizes kinetochore-microtubule (kt-MT) interactions. Forces produced by molecular…”
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Classical and Emerging Regulatory Mechanisms of Cytokinesis in Animal Cells by Verma, Vikash, Mogilner, Alex, Maresca, Thomas J

“…The primary goal of cytokinesis is to produce two daughter cells, each having a full set of chromosomes. To achieve this, cells assemble a dynamic structure…”
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Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk by Afonso, Olga, Castellani, Colleen M, Cheeseman, Liam P, Ferreira, Jorge G, Orr, Bernardo, Ferreira, Luisa T, Chambers, James J, Morais-de-Sá, Eurico, Maresca, Thomas J, Maiato, Helder

“…According to the prevailing 'clock' model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1…”
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Chromosome Segregation: Not to Put Too Fine a Point (Centromere) On It by Maresca, Thomas J.

“…Localization of the histone H3 variant Cse4 (CENP-A) at the ∼125 base pair point centromere in budding yeast directs assembly of a kinetochore that binds one…”
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Cell Division: Aurora B Illuminates a Checkpoint Pathway by Maresca, Thomas J.

“…Separating mitotic error correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by their interconnected relationships…”
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It's all relative: Centromere- versus pole-based error correction by Ye, Anna A, Maresca, Thomas J

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Cell Division: The Prehistorichore? by Cane, Stuart, Maresca, Thomas J.

“…The recent discovery of a novel kinetochore has important implications for our understanding of the evolution of chromosome segregation systems and also for…”
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Cell Division: Kinetochores SKAdaddle by Ye, Anna A, Maresca, Thomas J

“…Accurate chromosome segregation during cell division requires that kinetochores couple microtubule dynamics to chromosome movement. New research reveals that…”
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Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity by Maresca, Thomas J., Groen, Aaron C., Gatlin, Jesse C., Ohi, Ryoma, Mitchison, Timothy J., Salmon, Edward D.

“…During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2]. It is generally accepted that this RanGTP gradient is…”
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Chromosome Segregation: A Kinetochore Missing Link Is Found by Maresca, Thomas J.

“…During mitosis the kinetochore assembles on centromeric chromatin. The component that connects the chromatin-associated inner domain to the microtubule-binding…”
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Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts by Maresca, Thomas J, Freedman, Benjamin S, Heald, Rebecca

“…During cell division, condensation and resolution of chromosome arms and the assembly of a functional kinetochore at the centromere of each sister chromatid…”
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A celebration of the 25th anniversary of chromatin-mediated spindle assembly by Verma, Vikash, Maresca, Thomas J

“…Formation of a bipolar spindle is required for the faithful segregation of chromosomes during cell division. Twenty-five years ago, a transformative insight…”
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Micromanipulation studies of chromatin fibers in Xenopus egg extracts reveal ATP-dependent chromatin assembly dynamics by Yan, Jie, Maresca, Thomas J, Skoko, Dunja, Adams, Christian D, Xiao, Botao, Christensen, Morten O, Heald, Rebecca, Marko, John F

“…We have studied assembly of chromatin using Xenopus egg extracts and single DNA molecules held at constant tension by using magnetic tweezers. In the absence…”
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