Search Results - "Marek, Lindsay A."

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC by Singleton, Katherine R, Hinz, Trista K, Kleczko, Emily K, Marek, Lindsay A, Kwak, Jeff, Harp, Taylor, Kim, Jihye, Tan, Aik Choon, Heasley, Lynn E

“…The FGFR1 is a therapeutic target under investigation in multiple solid tumors and clinical trials of selective tyrosine kinase inhibitors (TKI) are underway…”
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EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases by Vaishnavi, Aria, Schubert, Laura, Rix, Uwe, Marek, Lindsay A, Le, Anh T, Keysar, Stephen B, Glogowska, Magdalena J, Smith, Matthew A, Kako, Severine, Sumi, Natalia J, Davies, Kurtis D, Ware, Kathryn E, Varella-Garcia, Marileila, Haura, Eric B, Jimeno, Antonio, Heasley, Lynn E, Aisner, Dara L, Doebele, Robert C

“…Oncogenic kinase fusions of , , , and act as drivers in human lung and other cancers. Residual tumor burden following treatment of ALK or ROS1 lung cancer…”
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Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma by Marek, Lindsay A, Hinz, Trista K, von Mässenhausen, Anne, Olszewski, Kyle A, Kleczko, Emily K, Boehm, Diana, Weiser-Evans, Mary C, Nemenoff, Raphael A, Hoffmann, Hans, Warth, Arne, Gozgit, Joseph M, Perner, Sven, Heasley, Lynn E

“…Malignant pleural mesothelioma (MPM) is associated with asbestos exposure and is a cancer that has not been significantly affected by small molecule-based…”
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FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies by WYNES, Murry W, HINZ, Trista K, DZIADZIUSZKO, Rafal, JASSEM, Jacek, WOJTYLAK, Szymon, SEJDA, Aleksandra, GOZGIT, Joseph M, BUNN, Paul A, CAMIDGE, D. Ross, TAN, Aik-Choon, HIRSCH, Fred R, HEASLEY, Lynn E, DEXIANG GAO, MARTINI, Michael, MAREK, Lindsay A, WARE, Kathryn E, EDWARDS, Michael G, BÖHM, Diana, PERNER, Sven, HELFRICH, Barbara A

“…FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The…”
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FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers by Göke, Friederike, Franzen, Alina, Hinz, Trista K, Marek, Lindsay A, Yoon, Petros, Sharma, Rakesh, Bode, Maike, von Maessenhausen, Anne, Lankat-Buttgereit, Brigitte, Göke, Antonia, Golletz, Carsten, Kirsten, Robert, Boehm, Diana, Vogel, Wenzel, Kleczko, Emily K, Eagles, Justin R, Hirsch, Fred R, Van Bremen, Tobias, Bootz, Friedrich, Schroeck, Andreas, Kim, Jihye, Tan, Aik-Choon, Jimeno, Antonio, Heasley, Lynn E, Perner, Sven

“…FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical…”
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Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines by Hinz, Trista K, Kleczko, Emily K, Singleton, Katherine R, Calhoun, Jacob, Marek, Lindsay A, Kim, Jihye, Tan, Aik Choon, Heasley, Lynn E

“…The inhibitory epidermal growth factor receptor (EGFR) antibody, cetuximab, is an approved therapy for head and neck squamous cell carcinoma (HNSCC). Despite…”
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A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines by Singleton, Katherine R, Kim, Jihye, Hinz, Trista K, Marek, Lindsay A, Casás-Selves, Matias, Hatheway, Clark, Tan, Aik Choon, DeGregori, James, Heasley, Lynn E

“…Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine…”
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Non-Amplified FGFR1 is a Growth Driver in Malignant Pleural Mesothelioma by Marek, Lindsay A., Hinz, Trista K., von Mässenhause, Anne, Olszewski, Kyle A., Kleczko, Emily K., Böhm, Diana, Weiser-Evans, Mary C., Nemenoff, Raphael A., Hoffmann, Hans, Warth, Arne, Gozgit, Joseph M., Perner, Sven, Heasley, Lynn E.

“…Malignant pleural mesothelioma (MPM) is associated with asbestos exposure and is a cancer that has not been significantly impacted by small molecule-based…”
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