Search Results - "Mardon, Helen J."

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss by Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Macklon, Nick S, Brosens, Jan J

“…Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus…”
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Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation by Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Brosens, Jan J, Macklon, Nick S

“…Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a…”
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Implantation of the Human Embryo Requires Rac1-Dependent Endometrial Stromal Cell Migration by Grewal, Seema, Carver, Janet G., Ridley, Anne J., Mardon, Helen J.

“…Failure of the human embryo to implant into the uterine wall during the early stages of pregnancy is a major cause of infertility. Implantation involves embryo…”
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Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading by Chillakuri, Chandramouli R, Jones, Céline, Mardon, Helen J

“…Vitronectin is a multi-functional protein found predominantly as a monomer in blood and as an oligomer in the extracellular matrix. We have dissected the…”
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Perfusion culture enhanced human endometrial stromal cell growth in alginate-multivalent integrin α5β1 ligand scaffolds by Li, Zhaohui, Kreiner, Michaela, Edrada-Ebel, RuAngelie, Cui, Zhanfeng, van der Walle, Christopher F., Mardon, Helen J.

“…A method to functionalize alginate by introducing monomeric or self‐assembling (tetrameric) fibronectin (FN) domains is described, leading to a functional…”
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Interdomain Tilt Angle Determines Integrin-dependent Function of the Ninth and Tenth FIII Domains of Human Fibronectin by Altroff, Harri, Schlinkert, Robin, van der Walle, Christopher F., Bernini, Andrea, Campbell, Iain D., Werner, Jörn M., Mardon, Helen J.

“…Integrins are an important family of signaling receptors that mediate diverse cellular processes. The binding of the abundant extracellular matrix ligand…”
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Synergistic Activity of the Ninth and Tenth FIII Domains of Human Fibronectin Depends upon Structural Stability by Altroff, Harri, Choulier, Laurence, Mardon, Helen J.

“…The ninth and tenth FIII domains (FIII9–10) of human fibronectin act in synergy to promote cell adhesion via the interaction with integrin receptors. Here we…”
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Human Endometrial Stromal Cell Rho GTPases Have Opposing Roles in Regulating Focal Adhesion Turnover and Embryo Invasion In Vitro by Grewal, Seema, Carver, Janet, Ridley, Anne J, Mardon, Helen J

“…Implantation of the embryo into the uterine compartment is a multistep event involving attachment of the embryo to the endometrial epithelia, followed by…”
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Functional Characterization of W147A: A High-Affinity Interleukin-11 Antagonist by Underhill-Day, Nicholas, McGovern, Lisa A, Karpovich, Natalia, Mardon, Helen J, Barton, Victoria A, Heath, John K

“…IL-11 is a member of the gp130 family of cytokines, which signal via assembly of multisubunit receptor complexes containing at least one molecule of the…”
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Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity by Klemmt, Petra A B, Carver, Janet G, Kennedy, Stephen H, Koninckx, Philippe R, Mardon, Helen J

“…To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating…”
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Module-module interactions in the cell binding region of fibronectin: stability, flexibility and specificity by Spitzfaden, Claus, Grant, Richard P, Mardon, Helen J, Campbell, Iain D

“…The structure of mosaic proteins depends on the nature and strength of interactions between individual modules. Here we investigated the structural…”
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Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression by Klemmt, Petra A.B., Carver, Janet G., Koninckx, Philippe, McVeigh, Enda J., Mardon, Helen J.

“…BACKGROUND Endometriosis, classified as the presence of endometrial cells in ectopic sites, is a debilitating disease causing pain and infertility in ∼10% of…”
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αVβ6 Is a Novel Receptor for Human Fibrillin-1: COMPARATIVE STUDIES OF MOLECULAR DETERMINANTS UNDERLYING INTEGRIN-RGD AFFINITY AND SPECIFICITY by Jovanović, Jelena, Takagi, Junichi, Choulier, Laurence, Abrescia, Nicola G.A, Stuart, David I, van der Merwe, P. Anton, Mardon, Helen J, Handford, Penny A

“…Human fibrillin-1, the major structural protein of connective tissue 10-12 nm microfibrils, contains multiple calcium binding epidermal growth factor-like…”
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Clustered integrin α5β1 ligand displays model fibronectin-mediated adhesion of human endometrial stromal cells by Li, Zhaohui, Kreiner, Michaela, van der Walle, Christopher F., Mardon, Helen J.

“…► A new substrate architecture for synthetic mimics of the cell extracellular matrix is presented. ► The substrates involve the synthesis of oriented,…”
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Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights into Microfibril Organization by Lee, Stephen S.J, Knott, Vroni, Jovanović, Jelena, Harlos, Karl, Grimes, Jonathan M, Choulier, Laurence, Mardon, Helen J, Stuart, David I, Handford, Penny A

“…Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10–12 nm microfibrils, is dominated by 43 calcium binding epidermal growth…”
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Human Endometrial Stromal Cell Rho GTPases Have Opposing Roles in Regulating Focal Adhesion Turnover and Embryo Invasion In Vitro1 by Grewal, Seema, Carver, Janet, Ridley, Anne J, Mardon, Helen J

“…Implantation of the embryo into the uterine compartment is a multistep event involving attachment of the embryo to the endometrial epithelia, followed by…”
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Heparin-Binding Epidermal Growth Factor and Its Receptors Mediate Decidualization and Potentiate Survival of Human Endometrial Stromal Cells by Chobotova, Katya, Karpovich, Natalia, Carver, Janet, Manek, Sanjiv, Gullick, William J., Barlow, David H., Mardon, Helen J.

“…Heparin-binding epidermal growth factor (HB-EGF) has pleiotropic biological functions in many tissues, including those of the female reproductive tract. It…”
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Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro by Klemmt, Petra A.B., Liu, Fang, Carver, Janet G., Jones, Celine, Brosi, Dorothea, Adamson, Jonathan, Mardon, Helen J., McVeigh, Enda

“…BACKGROUND Gonadotrophin releasing hormone (GnRH) analogues are widely used in IVF programmes as a method of suppressing the luteinizing hormone (LH) surge…”
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The Production of Interleukin-11 and Decidualization Are Compromised in Endometrial Stromal Cells Derived from Patients with Infertility by Karpovich, Natalia, Klemmt, Petra, Hwang, Jung Hye, McVeigh, J. Enda, Heath, John K., Barlow, David H., Mardon, Helen J.

“…IL-11 signaling is critical for decidualization of the endometrial stroma in early pregnancy in the mouse. In this study, we investigate the function of IL-11…”
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Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst by Chobotova, Katya, Spyropoulou, Isabella, Carver, Janet, Manek, Sanjiv, Heath, John K, Gullick, William J, Barlow, David H, Sargent, Ian L, Mardon, Helen J

“…The mechanisms that mediate implantation of the human embryo remain poorly understood and represent a fundamental problem in reproductive biology. Candidate…”
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