Search Results - "Marder, Karen S."

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk by MacLeod, David A., Rhinn, Herve, Kuwahara, Tomoki, Zolin, Ari, Di Paolo, Gilbert, McCabe, Brian D., Marder, Karen S., Honig, Lawrence S., Clark, Lorraine N., Small, Scott A., Abeliovich, Asa

“…Recent genome-wide association studies have linked common variants in the human genome to Parkinson’s disease (PD) risk. Here we show that the consequences of…”
Get full text

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease by Lindestam Arlehamn, Cecilia S., Dhanwani, Rekha, Pham, John, Kuan, Rebecca, Frazier, April, Rezende Dutra, Juliana, Phillips, Elizabeth, Mallal, Simon, Roederer, Mario, Marder, Karen S., Amara, Amy W., Standaert, David G., Goldman, Jennifer G., Litvan, Irene, Peters, Bjoern, Sulzer, David, Sette, Alessandro

“…A diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal…”
Get full text

Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis by Chan, Robin B, Perotte, Adler J, Zhou, Bowen, Liong, Christopher, Shorr, Evan J, Marder, Karen S, Kang, Un J, Waters, Cheryl H, Levy, Oren A, Xu, Yimeng, Shim, Hong Bin, Pe'er, Itsik, Di Paolo, Gilbert, Alcalay, Roy N

“…Parkinson's disease (PD) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy…”
Get full text

The association between Mediterranean diet adherence and Parkinson's disease by Alcalay, Roy N., Gu, Yian, Mejia-Santana, Helen, Cote, Lucien, Marder, Karen S., Scarmeas, Nikolaos

“…Background: Recent studies have demonstrated an association between a Mediterranean‐type diet and Alzheimer's risk. We assessed the association between…”
Get full text

Arm swing as a potential new prodromal marker of Parkinson's disease by Mirelman, Anat, Bernad-Elazari, Hagar, Thaler, Avner, Giladi-Yacobi, Eytan, Gurevich, Tanya, Gana-Weisz, Mali, Saunders-Pullman, Rachel, Raymond, Deborah, Doan, Nancy, Bressman, Susan B., Marder, Karen S., Alcalay, Roy N., Rao, Ashwini K., Berg, Daniela, Brockmann, Kathrin, Aasly, Jan, Waro, Bjørg Johanne, Tolosa, Eduardo, Vilas, Dolores, Pont-Sunyer, Claustre, Orr-Urtreger, Avi, Hausdorff, Jeffrey M., Giladi, Nir

“…ABSTRACT Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD), often observed early in the course of the disease. We…”
Get full text

Reply: More than a co-incidence? Exploring the increased frequency of amyotrophic lateral sclerosis in Huntington disease by Hickman, Richard A., Traynor, Bryan J., Marder, Karen S., Vonsattel, Jean-Paul

Get full text

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse by Singhania, Akul, Pham, John, Dhanwani, Rekha, Frazier, April, Rezende Dutra, Juliana, Marder, Karen S., Phillips, Elizabeth, Mallal, Simon, Amara, Amy W., Standaert, David G., Sulzer, David, Peters, Bjoern, Sette, Alessandro, Lindestam Arlehamn, Cecilia S.

“…The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of…”
Get full text

Recommendations of the Alzheimerʼs Disease–Related Dementias Conference by Montine, Thomas J, Koroshetz, Walter J, Babcock, Debra, Dickson, Dennis W, Galpern, Wendy R, Glymour, M Maria, Greenberg, Steven M, Hutton, Michael L, Knopman, David S, Kuzmichev, Andrey N, Manly, Jennifer J, Marder, Karen S, Miller, Bruce L, Phelps, Creighton H, Seeley, William W, Sieber, Beth-Anne, Silverberg, Nina B, Sutherland, Margaret, Torborg, Christine L, Waddy, Salina P, Zlokovic, Berislav V, Corriveau, Roderick A

“…The National Alzheimerʼs Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimerʼs Disease that is updated annually. In the Plan,…”
Get full text

Clinical and neuropathological features of progressive supranuclear palsy in Leucine rich repeat kinase (LRRK2) G2019S mutation carriers by Vilas, Dolores, Sharp, Madeleine, Gelpi, Ellen, Genís, David, Marder, Karen S., Cortes, Etty, Vonsattel, Jean‐Paul, Tolosa, Eduard, Alcalay, Roy N.

Get full text

T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls by Dhanwani, Rekha, Pham, John, Premlal, Ashmitaa Logandha Ramamoorthy, Frazier, April, Kumar, Atul, Pero, Maria Elena, Bartolini, Francesca, Dutra, Juliana Rezende, Marder, Karen S, Peters, Bjoern, Sulzer, David, Sette, Alessandro, Lindestam Arlehamn, Cecilia S

“…Alzheimer's disease (AD), a chronic multifactorial and complex neurodegenerative disorder is a leading cause of dementia. Recently, neuroinflammation has been…”
Get full text

Corrigendum: T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls by Dhanwani, Rekha, Pham, John, Premlal, Ashmitaa Logandha Ramamoorthy, Frazier, April, Kumar, Atul, Pero, Maria Elena, Bartolini, Francesca, Dutra, Juliana Rezende, Marder, Karen S, Peters, Bjoern, Sulzer, David, Sette, Alessandro, Lindestam Arlehamn, Cecilia S

“…[This corrects the article DOI: 10.3389/fnins.2020.00874.]…”
Get full text

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research by Wray, Selina, Self, Matthew, Lewis, Patrick A, Taanman, Jan-Willem, Ryan, Natalie S, Mahoney, Colin J, Liang, Yuying, Devine, Michael J, Sheerin, Una-Marie, Houlden, Henry, Morris, Huw R, Healy, Daniel, Marti-Masso, Jose-Felix, Preza, Elisavet, Barker, Suzanne, Sutherland, Margaret, Corriveau, Roderick A, D'Andrea, Michael, Schapira, Anthony H V, Uitti, Ryan J, Guttman, Mark, Opala, Grzegorz, Jasinska-Myga, Barbara, Puschmann, Andreas, Nilsson, Christer, Espay, Alberto J, Slawek, Jaroslaw, Gutmann, Ludwig, Boeve, Bradley F, Boylan, Kevin, Stoessl, A Jon, Ross, Owen A, Maragakis, Nicholas J, Van Gerpen, Jay, Gerstenhaber, Melissa, Gwinn, Katrina, Dawson, Ted M, Isacson, Ole, Marder, Karen S, Clark, Lorraine N, Przedborski, Serge E, Finkbeiner, Steven, Rothstein, Jeffrey D, Wszolek, Zbigniew K, Rossor, Martin N, Hardy, John

“…Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to…”
Get full text

Learning fast accurate movements requires intact frontostriatal circuits by Shabbott, Britne, Ravindran, Roshni, Schumacher, Joseph W, Wasserman, Paula B, Marder, Karen S, Mazzoni, Pietro

“…The basal ganglia are known to play a crucial role in movement execution, but their importance for motor skill learning remains unclear. Obstacles to our…”
Get full text

Clinical assessment of mobility and balance impairments in pre-symptomatic Huntington's disease by Rao, Ashwini K, Louis, Elan D, Marder, Karen S

“…Abstract Background Quantitative movement analysis can detect impairments in mobility and balance in persons with pre-symptomatic HD (pre-HD); however, it is…”
Get full text

SCARB2 variants and glucocerebrosidase activity in Parkinson’s disease by Alcalay, Roy N, Levy, Oren A, Wolf, Pavlina, Oliva, Petra, Zhang, Xiaokui Kate, Waters, Cheryl H, Fahn, Stanley, Kang, Un Jung, Liong, Christopher, Ford, Blair, Mazzoni, Pietro, Kuo, Sheng, Johnson, Amelie, Xiong, Lan, Rouleau, Guy A, Chung, Wendy K, Marder, Karen S, Gan-Or, Ziv

“…Mutations in glucocerebrosidase ( GBA ) are a common risk factor for Parkinson's disease (PD). The scavenger receptor class B member 2 ( SCARB2 ) gene encodes…”
Get full text

Research criteria for the diagnosis of prodromal dementia with Lewy bodies by McKeith, Ian G., Ferman, Tanis J., Thomas, Alan J., Blanc, Frédéric, Boeve, Bradley F., Fujishiro, Hiroshige, Kantarci, Kejal, Muscio, Cristina, O'Brien, John T., Postuma, Ronald B., Aarsland, Dag, Ballard, Clive, Bonanni, Laura, Donaghy, Paul, Emre, Murat, Galvin, James E., Galasko, Douglas, Goldman, Jennifer G., Gomperts, Stephen N., Honig, Lawrence S., Ikeda, Manabu, Leverenz, James B., Lewis, Simon J.G., Marder, Karen S., Masellis, Mario, Salmon, David P., Taylor, John Paul, Tsuang, Debby W., Walker, Zuzana, Tiraboschi, Pietro

“…The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset…”
Get full text

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk by MacLeod, David A., Rhinn, Herve, Kuwahara, Tomoki, Zolin, Ari, Di Paolo, Gilbert, McCabe, Brian D., Marder, Karen S., Honig, Lawrence S., Clark, Lorraine N., Small, Scott A., Abeliovich, Asa

Get full text

Quantifying Postural Control in Premanifest and Manifest Huntington Disease Using Wearable Sensors by Porciuncula, Franchino, Wasserman, Paula, Marder, Karen S., Rao, Ashwini K.

“…Background. Impairments in postural control in Huntington disease (HD) have important consequences for daily functioning. This observational study…”
Get full text

Longitudinal Patterns of Cortical Atrophy on MRI in Patients With Alzheimer Disease With and Without Lewy Body Pathology by Constant, Allison Beers, Basavaraju, Rakshathi, France, Jeanelle, Honig, Lawrence S., Marder, Karen S., Provenzano, Frank Anthony

“…Although Alzheimer disease (AD) and dementia with Lewy bodies (DLBs) represent 2 different pathologies, they have clinical overlap, and there is a significant…”
Get full text

CSF β-Amyloid 1-42 Predicts Progression to Cognitive Impairment in Newly Diagnosed Parkinson Disease by Terrelonge, Mark, Marder, Karen S., Weintraub, Daniel, Alcalay, Roy N.

“…Low CSF β-amyloid 1-42 has been associated with cognitive decline in advanced Parkinson’s disease; data from a single cohort suggest β-amyloid 1-42 may be an…”
Get full text