Search Results - "Marden, Chloe"

Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial by Kottaridis, Panagiotis D, North, Janet, Tsirogianni, Maria, Marden, Chloe, Samuel, Edward R, Jide-Banwo, Sam, Grace, Sarah, Lowdell, Mark W

“…Human Natural Killer (NK) cells require at least two signals to trigger tumor cell lysis. Absence of ligands providing either signal 1 or 2 provides NK…”
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Tumor-Primed Human Natural Killer Cells Lyse NK-Resistant Tumor Targets: Evidence of a Two-Stage Process in Resting NK Cell Activation by North, Janet, Bakhsh, Ismail, Marden, Chloe, Pittman, Hanna, Addison, Elena, Navarrete, Cristina, Anderson, Robert, Lowdell, Mark W

“…NK cells are defined as those cells that lyse tumor cells without priming. In this study, we show that the preincubation of resting human NK cells with the…”
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Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread by Boyton, Rosemary J., Davies, Selina, Marden, Chloe, Fantino, Cristina, Reynolds, Catherine, Portugal, Karina, Dewchand, Hamlata, Altmann, Daniel M.

“…There is much interest in therapeutic manipulation of cytokine responses in autoimmunity, yet studies in mouse models have sometimes produced conflicting…”
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Differentiation-dependent up-regulation of p47(phox) gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity by Marden, Chloe M, Stefanidis, Dimitrios, Cunninghame-Graham, Deborah S, Casimir, Colin M

“…The p47(phox) gene encodes a cytosolic component of the phagocytic NADPH oxidase complex. Expression of p47(phox) is both tissue-specific and developmentally…”
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Results of a Phase 1 Clinical Trial of Allogeneic Tumor-Primed Natural Killer Cells in AML by Kottaridis, Panagiotis, Tsirogianni, Maria, North, Janet, Marden, Chloe, Mackinnon, Stephen, Lowdell, Mark W

“…Abstract 946 We have previously reported that resting human NK cells can be primed to lyse NK-resistant tumor cells, including AML, by co-incubation with…”
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Ligation of CD8α on human natural killer cells prevents activation‐induced apoptosis and enhances cytolytic activity by Addison, Elena G., North, Janet, Bakhsh, Ismail, Marden, Chloe, Haq, Sumaira, Al‐Sarraj, Samia, Malayeri, Reza, Wickremasinghe, R. Gitendra, Davies, Jeffrey K., Lowdell, Mark W.

“…Summary It has been previously shown that the subset of human natural killer (NK) cells which express CD8 in a homodimeric α/α form are more cytotoxic than…”
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Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial: e0123416 by Kottaridis, Panagiotis D, North, Janet, Tsirogianni, Maria, Marden, Chloe, Samuel, Edward R, Jide-Banwo, Sam, Grace, Sarah, Lowdell, Mark W

“…Human Natural Killer (NK) cells require at least two signals to trigger tumor cell lysis. Absence of ligands providing either signal 1 or 2 provides NK…”
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Tumor-Activated Human NK Cells Specificall Ylyse Autologous and Allogeneic NK-Resistant Tumor Targets by Lowdell, Mark W., Bakhsh, Ismail, North, Janet, Marden, Chloe, Addison, Elena, Mackinnon, Stephen

“…Pre-incubation of resting human NK cells with the leukemia cell CTV-1 primes NK cells to lyse NK-resistant cell lines, primary leukemias and solid tumors, even…”
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Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen by Scott, Gary K, Marden, Chloe, Xu, Fan, Kirk, Liana, Benz, Christopher C

“…The antitumor activity of histone deacetylase (HDAC) inhibitors has been linked to gene expression induced by acetylation of histone and nonhistone proteins;…”
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Ligation of CD8[alpha] on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity by Addison, Elena G, North, Janet, Bakhsh, Ismail, Marden, Chloe

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CD69 Is Required for Activated NK Cell-Mediated Killing of Resistant Targets by Marden, Chloe M., North, Janet, Anderson, Robert, Bakhsh, Ismail A., Addison, Elena, Pittman, Hannah, Mackinnon, Stephen, Lowdell, Mark W.

“…The C-type lectin receptor CD69 is expressed on a range of haematopoietic cells following activation. On natural killer (NK) cells CD69 may play a direct role…”
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Differentiation-dependent up-regulation of p47phox gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity by Marden, Chloe M., Stefanidis, Dimitrios, Cunninghame-Graham, Deborah S., Casimir, Colin M.

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ORIGINAL ARTICLE: Ligation of CD8 alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity by Addison, Elena G, North, Janet, Bakhsh, Ismail, Marden, Chloe, Haq, Sumaira, Al-Sarraj, Samia, Malayeri, Reza, Wickremasinghe, RGitendra, Davies, Jeffrey K, Lowdell, Mark W

“…It has been previously shown that the subset of human natural killer (NK) cells which express CD8 in a homodimeric alpha - alpha form are more cytotoxic than…”
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Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity by Addison, Elena G, North, Janet, Bakhsh, Ismail, Marden, Chloe, Haq, Sumaira, Al-Sarraj, Samia, Malayeri, Reza, Wickremasinghe, R Gitendra, Davies, Jeffrey K, Lowdell, Mark W

“…It has been previously shown that the subset of human natural killer (NK) cells which express CD8 in a homodimeric alpha/alpha form are more cytotoxic than…”
Get full text

Differentiation-dependent up-regulation of p47 phox gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity by Marden, Chloe M., Stefanidis, Dimitrios, Cunninghame-Graham, Deborah S., Casimir, Colin M.

“…The p47 phox gene encodes a cytosolic component of the phagocytic NADPH oxidase complex. Expression of p47 phox is both tissue-specific and developmentally…”
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Transcriptional Repression of ErbB2 by Histone Deacetylase Inhibitors Detected by a Genomically Integrated ErbB2 Promoter-reporting Cell Screen 1 This research was supported in part by Grants R01-CA36773 and P50-CA58207 from the NIH as well as grants from the Hazel P. Munroe and Janet Landfear (Mt. Zion Health Systems) memorial funds.1 by Gary K. Scott, Chloe Marden, Fan Xu, Liana Kirk, Christopher C. Benz

“…The antitumor activity of histone deacetylase (HDAC) inhibitors has been linked to gene expression induced by acetylation of histone and nonhistone proteins;…”
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Enhanced Retroviral Transduction of 5-Fluorouracil–Resistant Human Bone Marrow (Stem) Cells Using a Genetically Modified Packaging Cell Line by Povey, Joanna, Weeratunge, Nishanthi, Marden, Chloe, Sehgal, Amita, Thrasher, Adrian, Casimir, Colin

“…Pluripotent hematopoietic stem cells (PHSC) are rare cells capable of multilineage differentiation, long-term reconstituting activity and extensive…”
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Enhanced retroviral transduction of 5-fluorouracil-resistant human bone marrow (stem) cells using a genetically modified packaging cell line by POVEY, J, WEERATUNGE, N, MARDEN, C, SEHGAL, A, THRASHER, A, CASIMIR, C

“…Pluripotent hematopoietic stem cells (PHSC) are rare cells capable of multilineage differentiation, long-term reconstituting activity and extensive…”
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Functional analysis of the p47phox gene promoter by Marden, Chloe Maria

“…Defects in the p47phox gene that encodes a cytosolic component of the phagocytic NADPH oxidase complex are responsible for the majority of cases of autosomal…”
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A functional ISRE is required for myeloid transcription of the p47(phox) gene by Marden, Chloe, Cunninghame Graham, Deborah, Thrasher, Adrian, Casimir, Colin

“…Expression of p47(phox), a component of the phagocytic NADPH oxidase, is both tissue-specific and developmentally regulated. We have investigated transcription…”
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