Search Results - "Marcus, J.P."

Safety of voriconazole in a patient with CYP2C92/CYP2C92 genotype by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Mikus, Gerd

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Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients by Geist, Marcus J. P., Ziesenitz, Victoria C., Bardenheuer, Hubert J., Burhenne, Juergen, Skopp, Gisela, Mikus, Gerd

“…Transdermal fentanyl is widely used to control pain in cancer patients. The high pharmacokinetic variability of fentanyl is assumed to be due to cytochrome…”
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Decreased Cytochrome P450 3A activity in palliative patients with haematological diseases: Potential impact on supportive drug therapies by Geist, Marcus J. P., Siller, Nelly, Egerer, Gerlinde, Bardenheuer, Hubert, Burhenne, Juergen, Mikus, Gerd

“…Cytochrome P450 3A (CYP3A) is the most relevant drug‐metabolizing enzyme in human beings involved in the elimination of about 50% of the marketed drugs…”
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Steady-state pharmacokinetics and metabolism of voriconazole in patients by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Weiss, Johanna, Mikus, Gerd

“…Voriconazole exhibits non-linear pharmacokinetics in adults and is said to be mainly metabolized by CYP2C19 and CYP3A4 to voriconazole-N-oxide. The aim of this…”
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Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions by Geist, Marcus J. P., Egerer, Gerlinde, Mikus, Gerd, Blank, Antje, Hohmann, Nicolas, Heinz, Werner J., Carls, Alexandra

“…Posaconazole prophylaxis is recommended for patients with acute myeloid leukaemia during induction chemotherapy. Although a tablet formulation with better oral…”
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In Vivo CYP3A Activity in Palliative Care Patients: Study Protocol for a Single Arm Prospective Trial by Geist, Marcus J P, Bardenheuer, Hubert J, Burhenne, Jürgen, Mikus, Gerd

“…Drug interactions are a common cause for escalation of debilitating symptoms in palliative care patients. CYP3A is the most relevant CYP enzyme in humans…”
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Consumption and domestic waste water demographic factors and developments in society by van der Wijst, M.A.J.E., Groot-Marcus, J.P.

“…Different types of households can be distinguished but as all households consume, they all contribute to the pollution of domestic waste water. The consumption…”
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Bleeding Control in Palliative Care Patients With the Help of Tranexamic Acid by Geist, Marcus J. P., Kessler, Jens, Frankenhauser, Susanne, Bardenheuer, Hubert J.

“…Background: Persistent bleeding is a common reason for admitting patients with advanced cancer to a palliative care unit. Several reports show a successful…”
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Induction of voriconazole metabolism by rifampin in a patient with acute myeloid leukemia: importance of interdisciplinary communication to prevent treatment errors with complex medications by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Mikus, Gerd

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Intensive Care-Led Echocardiography and FICE Accreditation by Peck, Marcus JE, Breen, Andrew, Jones, Nicola L, Morris, Craig, Russell, Conn

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MiAMP1, a novel protein from Macadamia integrifolia adopts a Greek key beta-barrel fold unique amongst plant antimicrobial proteins by McManus, A.M, Nielsen, K.J, Marcus, J.P, Harrison, S.J, Green, J.L, Manners, J.M, Craik, D.J

“…MiAMP1 is a recently discovered 76 amino acid residue, highly basic protein from the nut kernel of Macadamia integrifolia which possesses no sequence homology…”
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Purification, characterisation and cDNA cloning of an antimicrobial peptide from Macadamia integrifolia by Marcus, J.P, Goulter, K.C, Green, J.L, Harrison, S.J, Manners, J.M

“…An antimicrobial peptide with no significant amino acid sequence similarity to previously described peptides has been isolated from the nut kernels of…”
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Identification of a Second Active Site Residue in Escherichia coli L-Threonine Dehydrogenase: Methylation of Histidine-90 with Methyl p-Nitrobenzenesulfonate by Marcus, J.P., Dekker, E.E.

“…Incubation of L-threonine dehydrogenase from Escherichia coli with methyl p-nitrobenzenesulfonate results in a time- and concentration-dependent loss of…”
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pH-dependent decarboxylation of 2-amino-3-ketobutyrate, the unstable intermediate in the threonine dehydrogenase-initiated pathway for threonine utilization by Marcus, J P, Dekker, E E

“…2-Amino-3-ketobutyrate can be readily formed enzymatically by the action of L-threonine dehydrogenase. A convenient assay for determining the half-life of this…”
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