Search Results - "Marcus, Aaron"

New approaches for measurement of platelet reactivity by Marcus, Aaron J.

“…In a highly interesting, intricate, and novel paper in this issue of Blood, Fung and colleagues have extended their previous pioneering studies and now reveal…”
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Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39 by Hyman, Matthew C, Petrovic-Djergovic, Danica, Visovatti, Scott H, Liao, Hui, Yanamadala, Sunitha, Bouïs, Diane, Su, Enming J, Lawrence, Daniel A, Broekman, M Johan, Marcus, Aaron J, Pinsky, David J

“…Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells…”
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Increased platelet activation in sleep apnea subjects with intermittent hypoxemia by Krieger, Ana C., Anand, Ranjini, Hernandez-Rosa, Evelyn, Maidman, Allison, Milrad, Sara, DeGrazia, Miles Q., Choi, Alexander J., Oromendia, Clara, Marcus, Aaron J., Drosopoulos, Joan H. F.

“…Purpose Obstructive sleep apnea (OSA) is independently associated with increased risk for stroke and other cardiovascular diseases. Since activated platelets…”
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E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role by Aldi, Silvia, Marino, Alice, Tomita, Kengo, Corti, Federico, Anand, Ranjini, Olson, Kim E., Marcus, Aaron J., Levi, Roberto

“…Ischemia/reperfusion (I/R) elicits renin release from cardiac mast cells (MC), thus activating a local renin‐angiotensin system (RAS), culminating in…”
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Feedback Regulation of Endothelial Cell Surface Plasmin Generation by PKC-dependent Phosphorylation of Annexin A2 by He, Kai-Li, Sui, Guangzhi, Xiong, Huabao, Broekman, M. Johan, Huang, Bihui, Marcus, Aaron J., Hajjar, Katherine A.

“…In response to blood vessel injury, hemostasis is initiated by platelet activation, advanced by thrombin generation, and tempered by fibrinolysis. The primary…”
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Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk by Moeckel, Douglas, Jeong, Soon Soeg, Sun, Xiaofeng, Broekman, M Johan, Nguyen, Annie, Drosopoulos, Joan H F, Marcus, Aaron J, Robson, Simon C, Chen, Ridong, Abendschein, Dana

“…In patients with acute myocardial infarction undergoing reperfusion therapy to restore blood flow through blocked arteries, simultaneous inhibition of platelet…”
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The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons by Corti, Federico, Olson, Kim E, Marcus, Aaron J, Levi, Roberto

“…Once released, norepinephrine is removed from cardiac synapses via reuptake into sympathetic nerves, whereas transmitter ATP is catabolized by ecto-NTP…”
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Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis by Jacovina, Andrew T, Deora, Arunkumar B, Ling, Qi, Broekman, M Johan, Almeida, Dena, Greenberg, Caroline B, Marcus, Aaron J, Smith, Jonathan D, Hajjar, Katherine A

“…When plasma levels of homocysteine (HC), a thiol amino acid formed upon methionine demethylation, exceed 12 muM, individuals are at increased risk of…”
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Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization by Kopp, Hans-Georg, Hooper, Andrea T, Broekman, M Johan, Avecilla, Scott T, Petit, Isabelle, Luo, Min, Milde, Till, Ramos, Carlos A, Zhang, Fan, Kopp, Tabitha, Bornstein, Paul, Jin, David K, Marcus, Aaron J, Rafii, Shahin

“…Thrombopoietic cells may differentially promote or inhibit tissue vascularization by releasing both pro- and antiangiogenic factors. However, the molecular…”
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Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection by Marcus, Aaron J, Broekman, M Johan, Drosopoulos, Joan H F, Olson, Kim E, Islam, Naziba, Pinsky, David J, Levi, Roberto

“…Blood platelets maintain vascular integrity and promote primary and secondary hemostasis following interruption of vessel continuity. Biochemical or physical…”
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CD39/NTPDase-1 activity and expression in normal leukocytes by Pulte, E. Dianne, Broekman, M. Johan, Olson, Kim E, Drosopoulos, Joan H.F, Kizer, Jorge R, Islam, Naziba, Marcus, Aaron J

“…Abstract Introduction CD39/NTPDase-1 is a cell surface enzyme expressed on leukocytes and endothelial cells that metabolizes ATP to ADP and AMP. CD39 is…”
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Human solCD39 inhibits injury-induced development of neointimal hyperplasia by Drosopoulos, J H F, Kraemer, R, Shen, H, Upmacis, R K, Marcus, A J, Musi, E

“…Blood platelets provide the initial response to vascular endothelial injury, becoming activated as they adhere to the injured site. Activated platelets recruit…”
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Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain by Pinsky, David J, Broekman, M Johan, Peschon, Jacques J, Stocking, Kim L, Fujita, Tomoyuki, Ramasamy, Ravichandran, Connolly, Jr, E Sander, Huang, Judy, Kiss, Szilard, Zhang, Yuan, Choudhri, Tanvir F, McTaggart, Ryan A, Liao, Hui, Drosopoulos, Joan H F, Price, Virginia L, Marcus, Aaron J, Maliszewski, Charles R

“…Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in…”
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Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases by Marcus, Aaron J, Broekman, M Johan, Drosopoulos, Joan H F, Islam, Naziba, Pinsky, David J, Sesti, Casilde, Levi, Roberto

“…Platelets are responsible for maintaining vascular integrity. In thrombocytopenic states, vascular permeability and fragility increase, presumably due to the…”
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CD39 Expression on T Lymphocytes Correlates With Severity of Disease in Patients With Chronic Lymphocytic Leukemia by Pulte, Dianne, Furman, Richard R, Broekman, M. Johan, Drosopoulos, Joan H.F, Ballard, Harold S, Olson, Kim E, Kizer, Jorge R, Marcus, Aaron J

“…Abstract Introduction Chronic lymphocytic leukemia (CLL) is a B-cell disorder, but it is also associated with abnormalities in T-lymphocyte function. In this…”
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Integration of advanced practice providers into the Israeli healthcare system by Aaron, Eliana Marcus, Andrews, Caryn Scheinberg

“…Many countries around the world have integrated various types of Advanced Practice Providers (APPs) into their healthcare systems. The main motivating factors…”
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CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia by Pulte, Dianne, Olson, Kim E, Broekman, M Johan, Islam, Naziba, Ballard, Harold S, Furman, Richard R, Olson, Ashley E, Marcus, Aaron J

“…Chronic lymphocytic leukemia (CLL) is characterized by accumulation of mature appearing lymphocytes and is rarely complicated by thrombosis. One possible…”
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Platelet-erythrocyte interactions enhance αIIbβ3 integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo by Vallés, Juana, Santos, M. Teresa, Aznar, Justo, Martı́nez, Marcial, Moscardó, Antonio, Piñón, Marta, Broekman, M. Johan, Marcus, Aaron J.

“…Activated platelets release biologically active compounds, which then recruit additional platelets into an evolving thrombus. We studied activation of αIIbβ3…”
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Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors by Schaefer, Ulrich, Machida, Takuji, Broekman, M Johan, Marcus, Aaron J, Levi, Roberto

“…We previously reported that ATP coreleased with norepinephrine from cardiac sympathetic nerves activates presynaptic P2X purinoceptors (P2XR), thereby…”
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P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window by Fung, C Y E, Marcus, Aaron J, Broekman, M Johan, Mahaut-Smith, Martyn P

“…Thrombus formation at sites of disrupted atherosclerotic plaques is a leading cause of death and disability worldwide. Although the platelet is now recognized…”
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