Search Results - "Marcucci, Lorenzo"

Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation by Marcucci, Lorenzo

“…Contraction in striated muscle is classically described as regulated by calcium-mediated structural changes in the actin-containing thin filaments, which…”
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Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles by Pavan, Piero, Monti, Elena, Bondí, Michela, Fan, Chenglei, Stecco, Carla, Narici, Marco, Reggiani, Carlo, Marcucci, Lorenzo

“…Aging of human skeletal muscles is associated with increased passive stiffness, but it is still debated whether muscle fibers or extracellular matrix (ECM) are…”
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The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism beyond the Lever-Arm Swing by Marcucci, Lorenzo, Fukunaga, Hiroki, Yanagida, Toshio, Iwaki, Mitsuhiro

“…Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one of the most…”
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Proposed mechanism for the length dependence of the force developed in maximally activated muscles by Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio

“…The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown…”
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Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle by Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio

“…Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system…”
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Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling by Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio

“…Muscle contractions are generated by cyclical interactions of myosin heads with actin filaments to form the actomyosin complex. To simulate actomyosin complex…”
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Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model by Marcucci, Lorenzo, Bondì, Michela, Randazzo, Giulia, Reggiani, Carlo, Natali, Arturo N, Pavan, Piero G

“…The forces that allow body movement can be divided into active (generated by sarcomeric contractile proteins) and passive (sustained by intra-sarcomeric…”
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From single molecule fluctuations to muscle contraction: a Brownian model of A.F. Huxley's hypotheses by Marcucci, Lorenzo, Yanagida, Toshio

“…Muscular force generation in response to external stimuli is the result of thermally fluctuating, cyclical interactions between myosin and actin, which…”
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Cytosolic Ca2+ gradients and mitochondrial Ca2+ uptake in resting muscle fibers: A model analysis by Marcucci, Lorenzo, Michelucci, Antonio, Reggiani, Carlo

“…Calcium ions (Ca2+) enter mitochondria via the mitochondrial Ca2+ uniporter, driven by electrical and concentration gradients. In this regard, transgenic mouse…”
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A 3D diffusional-compartmental model of the calcium dynamics in cytosol, sarcoplasmic reticulum and mitochondria of murine skeletal muscle fibers by Marcucci, Lorenzo, Canato, Marta, Protasi, Feliciano, Stienen, Ger J M, Reggiani, Carlo

“…Variations of free calcium concentration ([Ca2+]) are powerful intracellular signals, controlling contraction as well as metabolism in muscle cells. To fully…”
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Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle by Marchioretti, Caterina, Zanetti, Giulia, Pirazzini, Marco, Gherardi, Gaia, Nogara, Leonardo, Andreotti, Roberta, Martini, Paolo, Marcucci, Lorenzo, Canato, Marta, Nath, Samir R., Zuccaro, Emanuela, Chivet, Mathilde, Mammucari, Cristina, Pacifici, Marco, Raffaello, Anna, Rizzuto, Rosario, Mattarei, Andrea, Desbats, Maria A., Salviati, Leonardo, Megighian, Aram, Sorarù, Gianni, Pegoraro, Elena, Belluzzi, Elisa, Pozzuoli, Assunta, Biz, Carlo, Ruggieri, Pietro, Romualdi, Chiara, Lieberman, Andrew P., Babu, Gopal J., Sandri, Marco, Blaauw, Bert, Basso, Manuela, Pennuto, Maria

“…Polyglutamine expansion in the androgen receptor (AR) causes spinobulbar muscular atrophy (SBMA). Skeletal muscle is a primary site of toxicity; however, the…”
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Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment by Marcucci, Lorenzo, Reggiani, Carlo

“…Elderly people perform more slowly movements of everyday life as rising from a chair, walking, and climbing stairs. This is in the first place due to the loss…”
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Double Diapering Ineffectiveness in Avoiding Adduction and Extension in Newborns Hips by De Pellegrin, Maurizio, Damia, Chiara Maria, Marcucci, Lorenzo, Moharamzadeh, Desiree

“…Hip flexion and abduction is fundamental for developmental dysplasia of the hip (DDH) treatment. At present, double diaper treatment has been inappropriately…”
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Switching of myosin-V motion between the lever-arm swing and Brownian search-and-catch by Fujita, Keisuke, Iwaki, Mitsuhiro, Iwane, Atsuko H., Marcucci, Lorenzo, Yanagida, Toshio

“…Motor proteins are force-generating nanomachines that are highly adaptable to their ever-changing biological environments and have a high energy conversion…”
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Excessive Accumulation of Ca2 + in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State by Canato, Marta, Capitanio, Paola, Cancellara, Lina, Leanza, Luigi, Raffaello, Anna, Reane, Denis Vecellio, Marcucci, Lorenzo, Michelucci, Antonio, Protasi, Feliciano, Reggiani, Carlo

“…Mice (Y522S or YS), carrying a mutation of the sarcoplasmic reticulum (SR) Ca2+ release channel of skeletal muscle fibers (ryanodine receptor type-1, RyR1)…”
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Resection of Calcaneonavicular and Talocalcaneal Coalitions With Surgical Correction of the Hindfoot Valgus Deformity in One Step by De Pellegrin, Maurizio, Marcucci, Lorenzo, Brogioni, Lorenzo, Fracassetti, Dario

“…Background: Calcaneonavicular (CNC) and talocalcaneal (TCC) coalitions are the most common cause of rigid flatfoot in children. After resection, correction of…”
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Surgical Treatment of Clubfoot in Children with Moebius Syndrome by De Pellegrin, Maurizio, Marcucci, Lorenzo, Brogioni, Lorenzo, Prati, Giovanni

“…Moebius syndrome (MS) is a rare disease, with paralysis of the VI and VII cranial nerves, frequently associated with clubfoot (CF). The aim of this study was…”
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Guided Growth in Leg Length Discrepancy in Beckwith-Wiedemann Syndrome: A Consecutive Case Series by De Pellegrin, Maurizio, Brogioni, Lorenzo, Laskow, Guy, Barera, Graziano, Pajno, Roberta, Osimani, Sara, Russo, Silvia, Marcucci, Lorenzo

“…Beckwith-Wiedemann Syndrome (BWS) is a rare genetic disorder characterized by overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycemia,…”
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Mechanosensing in Myosin Filament Solves a 60 Years Old Conflict in Skeletal Muscle Modeling between High Power Output and Slow Rise in Tension by Marcucci, Lorenzo, Reggiani, Carlo

“…Almost 60 years ago Andrew Huxley with his seminal paper (Huxley, 1957) laid the foundation of modern muscle modeling, linking chemical to mechanical events…”
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A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers? by Reggiani, Carlo, Marcucci, Lorenzo

“…Mitochondria are characterized by a high capacity to accumulate calcium thanks to the electrochemical gradient created by the extrusion of protons in the…”
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