Search Results - "Marcovina, Santica"

Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week by Tsimikas, Sotirios, Marcovina, Santica M

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Lipoprotein (a) measurements for clinical application by Marcovina, Santica M., Albers, John J.

“…The high degree of size heterogeneity of apo(a), the distinct protein component of lipoprotein (a) [Lp(a)], renders the development and selection of specific…”
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Lipoprotein(a): a genetically determined risk factor for Cardiovascular disease by Marcovina, Santica M.

“…Lipoprotein(a) is a complex lipoprotein with unique characteristics distinguishing it from all the other apolipoprotein B-containing lipoprotein particles. Its…”
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Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association by Reyes-Soffer, Gissette, Ginsberg, Henry N., Berglund, Lars, Duell, P. Barton, Heffron, Sean P., Kamstrup, Pia R., Lloyd-Jones, Donald M., Marcovina, Santica M., Yeang, Calvin, Koschinsky, Marlys L.

“…High levels of lipoprotein(a) [Lp(a)], an apoB100-containing lipoprotein, are an independent and causal risk factor for atherosclerotic cardiovascular diseases…”
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Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials by Viney, Nicholas J, BSc, van Capelleveen, Julian C, MD, Geary, Richard S, PhD, Xia, Shuting, MS, Tami, Joseph A, PharmD, Yu, Rosie Z, PhD, Marcovina, Santica M, Prof, Hughes, Steven G, MD, Graham, Mark J, MS, Crooke, Rosanne M, PhD, Crooke, Stanley T, MD, Witztum, Joseph L, Prof, Stroes, Erik S, Prof, Tsimikas, Sotirios, Prof

“…Summary Background Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific…”
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Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017 by Lawrence, Jean M, Divers, Jasmin, Isom, Scott, Saydah, Sharon, Imperatore, Giuseppina, Pihoker, Catherine, Marcovina, Santica M, Mayer-Davis, Elizabeth J, Hamman, Richard F, Dolan, Lawrence, Dabelea, Dana, Pettitt, David J, Liese, Angela D

“…IMPORTANCE: Changes in the prevalence of youth-onset diabetes have previously been observed. OBJECTIVE: To estimate changes in prevalence of type 1 and type 2…”
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Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study by Tsimikas, Sotirios, Prof, Viney, Nicholas J, BSc, Hughes, Steven G, MBBS, Singleton, Walter, MD, Graham, Mark J, MS, Baker, Brenda F, PhD, Burkey, Jennifer L, PhD, Yang, Qingqing, MS, Marcovina, Santica M, Prof, Geary, Richard S, PhD, Crooke, Rosanne M, PhD, Witztum, Joseph L, Prof

“…Summary Background Lipoprotein(a) (Lp[a]) is a risk factor for cardiovascular disease and calcific aortic valve stenosis. No effective therapies to lower…”
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NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis by Tsimikas, Sotirios, Fazio, Sergio, Ferdinand, Keith C., Ginsberg, Henry N., Koschinsky, Marlys L., Marcovina, Santica M., Moriarty, Patrick M., Rader, Daniel J., Remaley, Alan T., Reyes-Soffer, Gissette, Santos, Raul D., Thanassoulis, George, Witztum, Joseph L., Danthi, Simhan, Olive, Michelle, Liu, Lijuan

“…Pathophysiological, epidemiological, and genetic studies provide strong evidence that lipoprotein(a) [Lp(a)] is a causal mediator of cardiovascular disease…”
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Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012 by Mayer-Davis, Elizabeth J, Lawrence, Jean M, Dabelea, Dana, Divers, Jasmin, Isom, Scott, Dolan, Lawrence, Imperatore, Giuseppina, Linder, Barbara, Marcovina, Santica, Pettitt, David J, Pihoker, Catherine, Saydah, Sharon, Wagenknecht, Lynne

“…This study ascertained cases of type 1 and type 2 diabetes among youths from 2002 through 2012 at five U.S. study centers. After adjustment for age, sex, and…”
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Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study by Aroda, Vanita R, Edelstein, Sharon L, Goldberg, Ronald B, Knowler, William C, Marcovina, Santica M, Orchard, Trevor J, Bray, George A, Schade, David S, Temprosa, Marinella G, White, Neil H, Crandall, Jill P, the Diabetes Prevention Program Research Group

“…Context: Vitamin B12 deficiency may occur with metformin treatment, but few studies have assessed risk with long-term use. Objective: To assess the risk of B12…”
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Lp(a): When and how to measure it by Cegla, Jaimini, France, Michael, Marcovina, Santica M, Neely, R Dermot G

“…Lipoprotein(a) has long been regarded as a risk factor for cardiovascular disease; however, its routine use in clinical practice has been hampered by…”
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Controlled study of the effect of proprotein convertase subtilisin-kexin type 9 inhibition with evolocumab on lipoprotein(a) particle kinetics by Watts, Gerald F, Chan, Dick C, Somaratne, Ransi, Wasserman, Scott M, Scott, Rob, Marcovina, Santica M, Barrett, P Hugh R

“…Abstract Aims Lipoprotein(a) [Lp(a)], a low-density lipoprotein (LDL) particle covalently bound to apolipoprotein(a) [apo(a)], is a potentially potent…”
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Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor by Romagnuolo, Rocco, Scipione, Corey A., Boffa, Michael B., Marcovina, Santica M., Seidah, Nabil G., Koschinsky, Marlys L.

“…Elevated levels of lipoprotein(a) (Lp(a)) have been identified as an independent risk factor for coronary heart disease. Plasma Lp(a) levels are reduced by…”
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Measurement of Lipoprotein(a): A Once in a Lifetime Opportunity by Marcovina, Santica M., Shapiro, Michael D.

“…[Display omitted]…”
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Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth by Pihoker, Catherine, Gilliam, Lisa K, Ellard, Sian, Dabelea, Dana, Davis, Cralen, Dolan, Lawrence M, Greenbaum, Carla J, Imperatore, Giuseppina, Lawrence, Jean M, Marcovina, Santica M, Mayer-Davis, Elizabeth, Rodriguez, Beatriz L, Steck, Andrea K, Williams, Desmond E, Hattersley, Andrew T, for the SEARCH for Diabetes in Youth Study Group

“…Aims: Our study aims were to determine the frequency of MODY mutations (HNF1A, HNF4A, glucokinase) in a diverse population of youth with diabetes and to assess…”
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Apo(a) and ApoB Interact Noncovalently Within Hepatocytes: Implications for Regulation of Lp(a) Levels by Modulation of ApoB Secretion by Youssef, Amer, Clark, Justin R., Marcovina, Santica M., Boffa, Michael B., Koschinsky, Marlys L.

“…Elevated plasma Lp(a) (lipoprotein(a)) levels are associated with increased risk for atherosclerotic cardiovascular disease and aortic valve stenosis. However,…”
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Development and validation of an isoform-independent monoclonal antibody–based ELISA for measurement of lipoprotein(a) by Marcovina, Santica M., Navabi, Nazanin, Allen, Serena, Gonen, Ayelet, Witztum, Joseph L., Tsimikas, Sotirios

“…The study aims were to develop a new isoform-independent enzyme-linked immunoassay (ELISA) for the measurement of lipoprotein(a) [Lp(a)], validate its…”
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The SEARCH for Diabetes in Youth study: rationale, findings, and future directions by Hamman, Richard F, Bell, Ronny A, Dabelea, Dana, D'Agostino, Jr, Ralph B, Dolan, Lawrence, Imperatore, Giuseppina, Lawrence, Jean M, Linder, Barbara, Marcovina, Santica M, Mayer-Davis, Elizabeth J, Pihoker, Catherine, Rodriguez, Beatriz L, Saydah, Sharon

“…The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the…”
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Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9 by Romagnuolo, Rocco, Scipione, Corey A, Marcovina, Santica M, Gemin, Matthew, Seidah, Nabil G, Boffa, Michael B, Koschinsky, Marlys L

“…Elevated plasma concentrations of lipoprotein(a) (Lp(a)) are a causal risk factor for cardiovascular disease. The mechanisms underlying Lp(a) clearance from…”
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Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood by Dabelea, Dana, Stafford, Jeanette M, Mayer-Davis, Elizabeth J, D’Agostino, Ralph, Dolan, Lawrence, Imperatore, Giuseppina, Linder, Barbara, Lawrence, Jean M, Marcovina, Santica M, Mottl, Amy K, Black, Mary Helen, Pop-Busui, Rodica, Saydah, Sharon, Hamman, Richard F, Pihoker, Catherine

“…IMPORTANCE: The burden and determinants of complications and comorbidities in contemporary youth-onset diabetes are unknown. OBJECTIVE: To determine the…”
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