Search Results - "Marcovich, Irina"

The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family by Lipovsek, Marcela, Marcovich, Irina, Elgoyhen, Ana Belén

“…Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades. In…”
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Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11 by Marcovich, Irina, Baer, Nicholas K, Shubina-Oleinik, Olga, Eclov, Rachel, Beard, Clayton W, Holt, Jeffrey R

“…Gene therapy for genetic hearing loss is an emerging therapeutic modality for hearing restoration. However, the approach has not yet been translated into…”
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The role of PKA in the translational response to heat stress in Saccharomyces cerevisiae by Barraza, Carla E, Solari, Clara A, Marcovich, Irina, Kershaw, Christopher, Galello, Fiorella, Rossi, Silvia, Ashe, Mark P, Portela, Paula

“…Cellular responses to stress stem from a variety of different mechanisms, including translation arrest and relocation of the translationally repressed mRNAs to…”
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(E)‑3-Furan-2-yl‑N‑p‑tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation by Arias, Hugo R, Ghelardini, Carla, Lucarini, Elena, Tae, Han-Shen, Yousuf, Arsalan, Marcovich, Irina, Manetti, Dina, Romanelli, Maria Novella, Elgoyhen, Ana Belén, Adams, David J, Di Cesare Mannelli, Lorenzo

“…The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce…”
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Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit by Moglie, Marcelo J, Marcovich, Irina, Corradi, Jeremías, Carpaneto Freixas, Agustín E, Gallino, Sofía, Plazas, Paola V, Bouzat, Cecilia, Lipovsek, Marcela, Elgoyhen, Ana Belén

“…The α9α10 nicotinic acetylcholine receptor (nAChR) plays a fundamental role in inner ear physiology. It mediates synaptic transmission between efferent…”
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Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice by Wu, Jason, Solanes, Paola, Nist-Lund, Carl, Spataro, Sofia, Shubina-Oleinik, Olga, Marcovich, Irina, Goldberg, Hannah, Schneider, Bernard L., Holt, Jeffrey R.

“…AAV-mediated gene therapy is a promising approach for treating genetic hearing loss. Replacement or editing of the Tmc1 gene, encoding hair cell mechanosensory…”
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Key role of the TM2-TM3 loop in calcium potentiation of the α9α10 nicotinic acetylcholine receptor by Gallino, Sofia L., Agüero, Lucía, Boffi, Juan C., Schottlender, Gustavo, Buonfiglio, Paula, Dalamon, Viviana, Marcovich, Irina, Carpaneto, Agustín, Craig, Patricio O., Plazas, Paola V., Elgoyhen, Ana B.

“…The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-permeable ion channel that mediates synaptic transmission between…”
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Evolution and function of Tmc genes in mammalian hearing by Marcovich, Irina, Holt, Jeffrey R

“…Auditory sensation in the mammalian inner ear requires mechanosensitive hair cells and an elaborate array of molecules that form the sensory transduction…”
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Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors by Marcovich, Irina, Moglie, Marcelo J, Carpaneto Freixas, Agustín E, Trigila, Anabella P, Franchini, Lucia F, Plazas, Paola V, Lipovsek, Marcela, Elgoyhen, Ana Belén

“…Abstract The expansion and pruning of ion channel families has played a crucial role in the evolution of nervous systems. Nicotinic acetylcholine receptors…”
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Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line by Carpaneto Freixas, Agustín E, Moglie, Marcelo J, Castagnola, Tais, Salatino, Lucia, Domene, Sabina, Marcovich, Irina, Gallino, Sofia, Wedemeyer, Carolina, Goutman, Juan D, Plazas, Paola V, Elgoyhen, Ana Belén

“…The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons that aid…”
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Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function by Boffi, Juan Carlos, Marcovich, Irina, Gill-Thind, JasKiran K, Corradi, Jeremías, Collins, Toby, Lipovsek, María Marcela, Moglie, Marcelo, Plazas, Paola V, Craig, Patricio O, Millar, Neil S, Bouzat, Cecilia, Elgoyhen, Ana Belén

“…Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular…”
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