Search Results - "Marcotte, E M"

Discovery of uncharacterized cellular systems by genome-wide analysis of functional linkages by Marcotte, Edward M, Date, Shailesh V

“…We introduce a general computational method, applicable on a genome-wide scale, for the systematic discovery of uncharacterized cellular systems. Quantitative…”
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Detecting Protein Function and Protein-Protein Interactions from Genome Sequences by Marcotte, Edward M., Pellegrini, Matteo, Ng, Ho-Leung, Rice, Danny W., Yeates, Todd O., Eisenberg, David

“…A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting…”
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A combined algorithm for genome-wide prediction of protein function by Eisenberg, David, Marcotte, Edward M, Pellegrini, Matteo, Thompson, Michael J, Yeates, Todd O

“…The availability of over 20 fully sequenced genomes has driven the development of new methods to find protein function and interactions. Here we group proteins…”
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Reducing MCM levels in human primary T cells during the G0→G1 transition causes genomic instability during the first cell cycle by Orr, S J, Gaymes, T, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, G J, Marcotte, E M, Thomas, N S B

“…DNA replication is tightly regulated, but paradoxically there is reported to be an excess of MCM DNA replication proteins over the number of replication…”
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Measuring the dynamics of the proteome by Marcotte, E M

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Reducing MCM levels in human primary T cells during the G →G transition causes genomic instability during the first cell cycle by Orr, S J, Gaymes, T, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, G J, Marcotte, E M, Thomas, N S B

“…DNA replication is tightly regulated, but paradoxically there is reported to be an excess of MCM DNA replication proteins over the number of replication…”
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Protein function in the post-genomic era by Eisenberg, David, Marcotte, Edward M, Xenarios, Ioannis, Yeates, Todd O

“…Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of…”
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DIP: the database of interacting proteins by Xenarios, I, Rice, D W, Salwinski, L, Baron, M K, Marcotte, E M, Eisenberg, D

“…The Database of Interacting Proteins (DIP; http://dip.doe-mbi.ucla.edu) is a database that documents experimentally determined protein-protein interactions…”
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Assigning Protein Functions by Comparative Genome Analysis: Protein Phylogenetic Profiles by Pellegrini, Matteo, Marcotte, Edward M., Thompson, Michael J., Eisenberg, David, Yeates, Todd O.

“…Determining protein functions from genomic sequences is a central goal of bioinformatics. We present a method based on the assumption that proteins that…”
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Protein interaction networks from yeast to human by Bork, Peer, Jensen, Lars J, von Mering, Christian, Ramani, Arun K, Lee, Insuk, Marcotte, Edward M

“…Protein interaction networks summarize large amounts of protein–protein interaction data, both from individual, small-scale experiments and from automated…”
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A census of protein repeats by Marcotte, Edward M., Pellegrini, Matteo, Yeates, Todd O., Eisenberg, David

“…In this study, we analyzed all known protein sequences for repeating amino acid segments. Although duplicated sequence segments occur in 14 % of all proteins,…”
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LGL: Creating a Map of Protein Function with an Algorithm for Visualizing Very Large Biological Networks by Adai, Alex T., Date, Shailesh V., Wieland, Shannon, Marcotte, Edward M.

“…Networks are proving to be central to the study of gene function, protein–protein interaction, and biochemical pathway data. Visualization of networks is…”
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Comparative experiments on learning information extractors for proteins and their interactions by Bunescu, Razvan, Ge, Ruifang, Kate, Rohit J., Marcotte, Edward M., Mooney, Raymond J., Ramani, Arun K., Wong, Yuk Wah

“…Automatically extracting information from biomedical text holds the promise of easily consolidating large amounts of biological knowledge in…”
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Expression Deconvolution: A Reinterpretation of DNA Microarray Data Reveals Dynamic Changes in Cell Populations by Lu, Peng, Nakorchevskiy, Aleksey, Marcotte, Edward M.

“…Cells grow in dynamically evolving populations, yet this aspect of experiments often goes unmeasured. A method is proposed for measuring the population…”
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Mining literature for protein–protein interactions by Marcotte, Edward M., Xenarios, Ioannis, Eisenberg, David

“…Motivation: A central problem in bioinformatics is how to capture information from the vast current scientific literature in a form suitable for analysis by…”
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The need for a public proteomics repository by Marcotte, Edward M, Prince, John T, Carlson, Mark W, Wang, Rong, Lu, Peng

“…Large-scale protein expression measurements promise to open exciting areas of research, ranging from systematic investigations of post-transcriptional…”
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Computational genetics: finding protein function by nonhomology methods by Marcotte, Edward M

“…During the past year, computational methods have been developed that use the rapidly accumulating genomic data to discover protein function. The methods rely…”
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Diametrical clustering for identifying anti-correlated gene clusters by Dhillon, Inderjit S., Marcotte, Edward M., Roshan, Usman

“…Motivation: Clustering genes based upon their expression patterns allows us to predict gene function. Most existing clustering algorithms cluster genes…”
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Localizing Proteins in the Cell from Their Phylogenetic Profiles by Marcotte, Edward M., Xenarios, Ioannis, Van der Bliek, Alexander M., Eisenberg, David

“…We introduce a computational method for identifying subcellular locations of proteins from the phylogenetic distribution of the homologs of organellar…”
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DIP: The Database of Interacting Proteins: 2001 update by Xenarios, I, Fernandez, E, Salwinski, L, Duan, X J, Thompson, M J, Marcotte, E M, Eisenberg, D

“…The Database of Interacting Proteins (DIP; http://dip.doe-mbi.ucla. edu) is a database that documents experimentally determined protein-protein interactions…”
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