Search Results - "Marcos, Malumbres"

Physiological relevance of cell cycle kinases by Malumbres, Marcos

“…The basic biology of the cell division cycle and its control by protein kinases was originally studied through genetic and biochemical studies in yeast and…”
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CDK4/6 Inhibitors: What Is the Best Cocktail? by Malumbres, Marcos

“…CDK4/6 inhibitors have shown great potential in the new armamentarium against cancer. However, their effect as single agents is limited, and the hopes are on…”
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Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition by Álvarez-Fernández, Mónica, Malumbres, Marcos

“…Inhibiting the cell-cycle kinases CDK4 and CDK6 results in significant therapeutic effect in patients with advanced hormone-positive breast cancer. The…”
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miRNAs versus oncogenes: the power of social networking by Malumbres, Marcos

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From Plk1 to Plk5: Functional evolution of polo-like kinases by de Cárcer, Guillermo, Manning, Gerard, Malumbres, Marcos

“…Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal protein kinase domain and a C-terminal polo-box domain (PBD) involved in…”
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The cell proliferation antigen Ki-67 organises heterochromatin by Sobecki, Michal, Mrouj, Karim, Camasses, Alain, Parisis, Nikolaos, Nicolas, Emilien, Llères, David, Gerbe, François, Prieto, Susana, Krasinska, Liliana, David, Alexandre, Eguren, Manuel, Birling, Marie-Christine, Urbach, Serge, Hem, Sonia, Déjardin, Jérôme, Malumbres, Marcos, Jay, Philippe, Dulic, Vjekoslav, Lafontaine, Denis Lj, Feil, Robert, Fisher, Daniel

“…Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear…”
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Plk1 overexpression induces chromosomal instability and suppresses tumor development by de Cárcer, Guillermo, Venkateswaran, Sharavan Vishaan, Salgueiro, Lorena, El Bakkali, Aicha, Somogyi, Kalman, Rowald, Konstantina, Montañés, Pablo, Sanclemente, Manuel, Escobar, Beatriz, de Martino, Alba, McGranahan, Nicholas, Malumbres, Marcos, Sotillo, Rocío

“…Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target…”
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CDK6 as a key regulator of hematopoietic and leukemic stem cell activation by Scheicher, Ruth, Hoelbl-Kovacic, Andrea, Bellutti, Florian, Tigan, Anca-Sarmiza, Prchal-Murphy, Michaela, Heller, Gerwin, Schneckenleithner, Christine, Salazar-Roa, María, Zöchbauer-Müller, Sabine, Zuber, Johannes, Malumbres, Marcos, Kollmann, Karoline, Sexl, Veronika

“…The cyclin-dependent kinase 6 (CDK6) and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic…”
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Squamous differentiation requires G2/mitosis slippage to avoid apoptosis by Sanz-Gómez, Natalia, de Pedro, Isabel, Ortigosa, Beatriz, Santamaría, David, Malumbres, Marcos, de Cárcer, Guillermo, Gandarillas, Alberto

“…The cellular mechanisms controlling cell fate in self-renewal tissues remain unclear. Cell cycle failure often leads to an apoptosis anti-oncogenic response…”
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CDK inhibitors in cancer therapy: what is next? by Malumbres, Marcos, Pevarello, Paolo, Barbacid, Mariano, Bischoff, James R

“…The pursuit for drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. The first-generation…”
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Control of cell proliferation pathways by microRNAs by Bueno, María José, de Castro, Ignacio Pérez, Malumbres, Marcos

“…microRNAs (miRNAs) are small non-coding RNAs that regulate a large variety of cellular processes including differentiation, apoptosis and proliferation…”
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Cell cycle control of pituitary development and disease by Quereda, Victor, Malumbres, Marcos

“…The pituitary gland regulates diverse physiological functions, including growth, metabolism, reproduction, stress response, and ageing. Early genetic models in…”
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Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells by Rata, Scott, Suarez Peredo Rodriguez, Maria F., Joseph, Stephy, Peter, Nisha, Echegaray Iturra, Fabio, Yang, Fengwei, Madzvamuse, Anotida, Ruppert, Jan G., Samejima, Kumiko, Platani, Melpomeni, Alvarez-Fernandez, Monica, Malumbres, Marcos, Earnshaw, William C., Novak, Bela, Hochegger, Helfrid

“…Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive…”
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Splicing together sister chromatids by Valcárcel, Juan, Malumbres, Marcos

“…Splicing of pre‐mRNAs is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site…”
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The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions by Manchado, Eusebio, Eguren, Manuel, Malumbres, Marcos

“…The APC/C (anaphase-promoting complex/cyclosome) is an E3 ubiquitin ligase that targets specific substrates for degradation by the 26S proteasome. APC/C…”
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An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability by Mitxelena, Jone, Apraiz, Aintzane, Vallejo-Rodríguez, Jon, García-Santisteban, Iraia, Fullaondo, Asier, Alvarez-Fernández, Mónica, Malumbres, Marcos, Zubiaga, Ana M

“…Abstract The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in…”
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Non-mitotic functions of the Anaphase-Promoting Complex by Eguren, Manuel, Manchado, Eusebio, Malumbres, Marcos

“…The Anaphase-Promoting Complex or Cyclosome (APC/C) is an E3 ubiquitin ligase whose activation requires the binding of a cofactor, either Cdc20 or Cdh1. While…”
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Cyclin-dependent kinases by Malumbres, Marcos

“…Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic…”
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Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma by López-Nieva, Pilar, Fernández-Navarro, Pablo, Graña-Castro, Osvaldo, Andrés-León, Eduardo, Santos, Javier, Villa-Morales, María, Cobos-Fernández, María Ángeles, González-Sánchez, Laura, Malumbres, Marcos, Salazar-Roa, María, Fernández-Piqueras, José

“…Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs…”
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The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes by Frangini, Alberto, Sjöberg, Marcela, Roman-Trufero, Monica, Dharmalingam, Gopuraja, Haberle, Vanja, Bartke, Till, Lenhard, Boris, Malumbres, Marcos, Vidal, Miguel, Dillon, Niall

“…Reversible cellular quiescence is critical for developmental processes in metazoan organisms and is characterized by a reduction in cell size and…”
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