Regenerative treatment of canine osteogenic lesions with Platelet-Rich Plasma and hydroxyapatite: a case report

This study examined the efficacy of a therapy based on a combination of Platelet Rich Plasma and hydroxyapatite nanoparticles in a severe clinical case involving a young Rottweiler with a complex spiral fracture of the tibia. Following a worsening of the lesion after traditional surgical interventio...

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Bibliographic Details
Published in:	Frontiers in veterinary science Vol. 11; p. 1459714
Main Authors:	Barbaro, Katia, Marconi, Giorgio, Innocenzi, Elisa, Altigeri, Annalisa, Zepparoni, Alessia, Monteleone, Valentina, Alimonti, Cristian, Marcoccia, Daniele, Ghisellini, Paola, Rando, Cristina, Ottoboni, Stefano, Rau, Julietta V, Eggenhöffner, Roberto, Scicluna, Maria Teresa
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 23-09-2024
Subjects:	case report hydroxyapatite nanoparticles ImageJ analysis platelet-rich plasma veterinary regenerative medicine Veterinary Science case report hydroxyapatite nanoparticles platelet-rich plasma veterinary regenerative medicine ImageJ analysis
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Summary:	This study examined the efficacy of a therapy based on a combination of Platelet Rich Plasma and hydroxyapatite nanoparticles in a severe clinical case involving a young Rottweiler with a complex spiral fracture of the tibia. Following a worsening of the lesion after traditional surgical intervention, the subject was treated with the combined therapy. X-rays were taken at the following stages: immediately post-surgery, four weeks post-surgery, and 10 days post-treatment. Fracture gap and callus density measurements were obtained using ImageJ analysis, allowing for a detailed quantitative assessment of bone regeneration over time. Post-operative radiographs indicated a clinical worsening of the fracture, revealing an increased fracture gap due to bone loss. However, significant improvements were observed ten days following the treatment, with a marked reduction in fracture gaps and increased callus density. These results demonstrated a notable acceleration in bone healing and callus formation compared to typical recovery times for similar lesions. The method showed potential for enhancing osteogenic regeneration, facilitating faster healing of serious orthopedic injuries compared to traditional methods.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Mudasir Bashir Gugjoo, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, India Edited by: Khan Sharun, Indian Veterinary Research Institute, India Reviewed by: Luca Melotti, University of Padua, Italy
ISSN:	2297-1769 2297-1769
DOI:	10.3389/fvets.2024.1459714