Search Results - "Marcondes, Mario"

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation by Bhagat, Tushar D, Chen, Si, Bartenstein, Matthias, Barlowe, A Trevor, Von Ahrens, Dagny, Choudhary, Gaurav S, Tivnan, Patrick, Amin, Elianna, Marcondes, A Mario, Sanders, Mathijs A, Hoogenboezem, Remco M, Kambhampati, Suman, Ramachandra, Nandini, Mantzaris, Iaonnis, Sukrithan, Vineeth, Laurence, Remi, Lopez, Robert, Bhagat, Prafullla, Giricz, Orsi, Sohal, Davendra, Wickrema, Amittha, Yeung, Cecilia, Gritsman, Kira, Aplan, Peter, Hochedlinger, Konrad, Yu, Yiting, Pradhan, Kith, Zhang, Jinghang, Greally, John M, Mukherjee, Siddhartha, Pellagatti, Andrea, Boultwood, Jacqueline, Will, Britta, Steidl, Ulrich, Raaijmakers, Marc H G P, Deeg, H Joachim, Kharas, Michael G, Verma, Amit

“…The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the…”
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The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy by Karoopongse, Ekapun, Yeung, Cecilia, Byon, John, Ramakrishnan, Aravind, Holman, Zaneta J, Jiang, Peter Y Z, Yu, Qiang, Deeg, H Joachim, Marcondes, A Mario

“…Both DNA and histone methylation are dysregulated in the myelodysplastic syndromes (MDS). Based on preliminary data we hypothesized that dysregulated…”
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Pre-transplant expressions of microRNAs, comorbidities, and post-transplant mortality by Sorror, Mohamed L., Gooley, Ted A., Maclean, Kirsteen H., Hubbard, Jesse, Marcondes, Mario A., Torok-Storb, Beverly J., Tewari, Muneesh

“…We analyzed micro-RNAs (miRs) as possible diagnostic biomarkers for relevant comorbidities prior to and prognostic biomarkers for mortality following…”
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Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model by Marcondes, A. Mario, Li, Xiang, Tabellini, Laura, Bartenstein, Matthias, Kabacka, Julia, Sale, George E., Hansen, John A., Dinarello, Charles A., Deeg, H. Joachim

“…Interleukin (IL)–32 was originally identified in natural killer cells and IL-2–activated human T lymphocytes. As T cells are activated in allogeneic…”
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Phase I study protocol: NKTR-255 as monotherapy or combined with daratumumab or rituximab in hematologic malignancies by Shah, Nina, Perales, Miguel-Angel, Turtle, Cameron J, Cairo, Mitchell S, Cowan, Andrew J, Saeed, Hayder, Budde, Lihua E, Tan, Alan, Lee, Zachary, Kai, Kazuharu, Marcondes, Mario Q, Zalevsky, Jonathan, Tagliaferri, Mary A, Patel, Krina K

“…NKTR-255 is an investigational polyethylene glycol-modified recombinant human IL-15 (rhIL-15) receptor agonist, designed to improve the immunotherapeutic and…”
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Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function by Marcondes, A. Mario, Mhyre, Andrew J, Stirewalt, Derek L, Kim, Soo-Hyun, Dinarello, Charles A, Deeg, H. Joachim

“…TNFα levels are elevated in the marrows of patients with myelodysplastic syndrome (MDS) and are associated with high rates of apoptosis, which contributes to…”
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Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion by Frenzel, Eileen, Wrenger, Sabine, Immenschuh, Stephan, Koczulla, Rembert, Mahadeva, Ravi, Deeg, H Joachim, Dinarello, Charles A, Welte, Tobias, Marcondes, A Mario Q, Janciauskiene, Sabina

“…The angiopoietin-like protein 4 (angptl4, also known as peroxisome proliferator-activated receptor [PPAR]γ-induced angiopoietin-related protein) is a…”
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Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes by Li, Xiang, Xu, Feng, Chang, ChunKang, Byon, John, Papayannopoulou, Thalia, Deeg, H Joachim, Marcondes, A Mario

“…The transcription factor TWIST-1 is up-regulated in CD34(+) cells in myelodysplastic syndrome and is involved in resistance to apoptosis. There is evidence…”
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Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy by Luo, Wen, Hoang, Hai, Zhu, Hongwen, Miller, Katherine, Mo, Xiaokui, Eguchi, Shiori, Tian, Meijuan, Liao, Yanling, Ayello, Janet, Rosenblum, Jeremy M, Marcondes, Mario, Currier, Mark, Mardis, Elaine, Cripe, Timothy, Lee, Dean, Cairo, Mitchell S

“…BackgroundPediatric patients with recurrent/metastatic Ewing sarcoma (ES) have a dismal 5-year survival. Novel therapeutic approaches are desperately needed…”
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A novel polymer-conjugated human IL-15 improves efficacy of CD19-targeted CAR T-cell immunotherapy by Hirayama, Alexandre V., Chou, Cassie K., Miyazaki, Takahiro, Steinmetz, Rachel N., Di, Henna A., Fraessle, Simon P., Gauthier, Jordan, Fiorenza, Salvatore, Hawkins, Reed M., Overwijk, Willem W., Riddell, Stanley R., Marcondes, Mario Q., Turtle, Cameron J.

“…•Polymer-conjugated IL-15 (NKTR-255) induced CD8+ and CD4+ T-cell and natural killer cell proliferation in nonhuman primates.•NKTR-255 enhanced the efficacy of…”
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957 NKTR-255+cetuximab in patients with solid tumors: interim safety and efficacy results from the phase 1b dose-escalation study by Altan, Mehmet, Patnaik, Amita, Barve, Minal, Dunn, Lara, Cobb, Patrick, Rosenberg, Ari, Sharma, Sunil, Sukari, Ammar, Patel, Manish, Wang, Xiaoli, Ma, Haijun, Dixit, Neha, Nieves, Wildaliz, Fanton, Christie, Currie, Sue, Lee, Zachary, Marcondes, Mario, Zalevsky, Johnathan, Tagliaferri, Mary, Sacco, Assuntina

“…BackgroundNKTR-255 is an investigational IL-15Rα-dependent, polymer-conjugated, recombinant human IL-15 agonist designed to provide sustained pharmacodynamic…”
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368 REVEAL: Phase 1 dose-escalation study of NKTR-262, a novel TLR7/8 agonist, plus bempegaldesleukin: local innate immune activation and systemic adaptive immune expansion for treating solid tumors by Diab, Adi, Curti, Brendan, Bilen, Mehmet, Brohl, Andrew, Domingo-Musibay, Evidio, Borazanci, Erkut, Fanton, Christie, Haglund, Cat, Vimal, Mona, Muhsin, Mann, Marcondes, Mario, Nguyen, Anh, Tagliaferri, Mary, Lin, Wei, Zalevsky, Jonathan, D’Angelo, Sandra

“…BackgroundNKTR-262 is a small-molecule agonist of toll-like receptors (TLR) 7/8. Given by intratumoral (IT) injection, NKTR-262 is retained within the tumor…”
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DNA Methylation and Gene Expression Profiling of Ewing Sarcoma Primary Tumors Reveal Genes That Are Potential Targets of Epigenetic Inactivation by Patel, Nikul, Black, Jennifer, Chen, Xi, Marcondes, A. Mario, Grady, William M., Lawlor, Elizabeth R., Borinstein, Scott C.

“…The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded…”
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A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia by Srinagesh, Hrishikesh, Jackson, Clayton, Shiraz, Parveen, Jeyakumar, Nikeshan, Hamilton, Mark, Egeler, Emily, Mavroukakis, Sharon, Kuo, Adam, Cancilla, Juancarlos, Sahaf, Bita, Agarwal, Neha, Kanegai, Alyssa, Kramer, Anne Marijn, Arai, Sally, Bharadwaj, Sushma, Dahiya, Saurabh, Hosoya, Hitomi, Johnston, Laura, Kennedy, Vanessa, Liedtke, Michaela, Lowsky, Robert, Mikkilineni, Lekha, Negrin, Robert, Rezvani, Andrew, Sidana, Surbhi, Shizuru, Judith, Smith, Melody, Weng, Wen-Kai, Feldman, Steven, Frank, Matthew J., Lee, Zachary, Tagliaferri, Mary, Marcondes, A. Mario, Miklos, David, Mackall, Crystal, Muffly, Lori

“…•Combining CAR-T cells targeting CD19 & CD22 with a recombinant, polymer-conjugated IL15 receptor agonist (NKTR-255) was safe and feasible.•NKTR-255 was…”
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Hematopoietic cell transplantation for patients with myelodysplastic syndromes (MDS): When, how and for whom? by Marcondes, Mario, MD, Deeg, H. Joachim, MD

“…Hematopoietic cell transplantation (HCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS). However, who should and can be…”
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α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression by Frenzel, Eileen, Wrenger, Sabine, Brügger, Britta, Salipalli, Sandeep, Immenschuh, Stephan, Aggarwal, Nupur, Lichtinghagen, Ralf, Mahadeva, Ravi, Marcondes, A Mario Q, Dinarello, Charles A, Welte, Tobias, Janciauskiene, Sabina

“…α1-Antitrypsin (A1AT) purified from human plasma upregulates expression and release of angiopoietin-like protein 4 (Angptl4) in adherent human blood monocytes…”
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α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics by Marcondes, A. Mario, Karoopongse, Ekapun, Lesnikova, Marina, Margineantu, Daciana, Welte, Tobias, Dinarello, Charles A., Hockenbery, David, Janciauskiene, Sabina, Deeg, H. Joachim

“…Hematopoietic cell transplantation is curative in many patients. However, graft-versus-host disease (GVHD), triggered by alloreactive donor cells, has remained…”
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Effects of Carvedilol Treatment in Dogs with Chronic Mitral Valvular Disease by Marcondes-Santos, M, Tarasoutchi, F, Mansur, A.P, Strunz, C.M.C

“…Background: Stimulation of the sympathetic nervous system occurs during the development of heart failure in dogs with chronic mitral valvular disease (CMVD)…”
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The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes by Li, Xiang, Marcondes, A. Mario, Gooley, Theodore A., Deeg, H. Joachim

“…Patients with low-grade myelodysplastic syndromes (MDS) show high levels of tumor necrosis factor α (TNFα) and up-regulation of apoptosis in the marrow. In…”
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Combinatorial immunotherapy of anti-MCAM CAR-modified expanded natural killer cells and NKTR-255 against neuroblastoma by Luo, Wen, Gardenswartz, Aliza, Hoang, Hai, Chu, Yaya, Tian, Meijuan, Liao, Yanling, Ayello, Janet, Rosenblum, Jeremy M., Mo, Xiaokui, Marcondes, A. Mario, Overwijk, Willem W., Cripe, Timothy P., Lee, Dean A., Cairo, Mitchell S.

“…Pediatric patients with recurrent metastatic neuroblastoma (NB) have a dismal 5-year survival. Novel therapeutic approaches are urgently needed. The melanoma…”
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