Search Results - "Marcocci, Elena"
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Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice
Published in PLoS pathogens (14-03-2019)“…Herpes simplex virus type 1 (HSV-1) is a DNA neurotropic virus, usually establishing latent infections in the trigeminal ganglia followed by periodic…”
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Redox-Modulating Agents in the Treatment of Viral Infections
Published in International journal of molecular sciences (08-06-2020)“…Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, several intracellular factors, including the redox state,…”
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Intracellular redox state as target for anti-influenza therapy: are antioxidants always effective?
Published in Current topics in medicinal chemistry (01-11-2014)“…Influenza virus infections represent a big issue for public health since effective treatments are still lacking. In particular, the emergence of strains…”
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Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
Published in Scientific reports (21-10-2015)“…Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer’s Disease (AD)…”
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5
Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs
Published in International journal of molecular sciences (13-02-2022)“…The COVID-19 pandemic has evidenced the urgent need for the discovery of broad-spectrum antiviral therapies that could be deployed in the case of future…”
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Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models
Published in International journal of molecular sciences (11-06-2021)“…Herpes simplex virus 1 (HSV-1) is a widespread neurotropic virus establishing a life-long latent infection in neurons with periodic reactivations. Recent…”
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A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity In Vitro
Published in Molecules (Basel, Switzerland) (17-08-2018)“…DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially and physiologically ripe aubergine berries, were studied for the…”
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Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
Published in International journal of molecular sciences (06-06-2022)“…The increasing resistance to conventional antifungal drugs is a widespread concern, and a search for new compounds, active against different species of fungi,…”
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Experimental Data Based Machine Learning Classification Models with Predictive Ability to Select in Vitro Active Antiviral and Non-Toxic Essential Oils
Published in Molecules (Basel, Switzerland) (25-05-2020)“…In the last decade essential oils have attracted scientists with a constant increase rate of more than 7% as witnessed by almost 5000 articles. Among the…”
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10
Autosomal dominant Alport syndrome: molecular analysis of the COL4A4 gene and clinical outcome
Published in Nephrology, dialysis, transplantation (01-05-2009)“…Background. Alport syndrome is a clinically and genetically heterogeneous nephropathy characterized by glomerular basement membrane lesions often associated…”
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11
APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells
Published in PloS one (15-11-2010)“…Lifelong latent infections of the trigeminal ganglion by the neurotropic herpes simplex virus type 1 (HSV-1) are characterized by periodic reactivation. During…”
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The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV
Published in International journal of molecular sciences (28-06-2022)“…Herpes simplex virus type-1 (HSV-1) and John Cunningham polyomavirus (JCPyV) are widely distributed DNA viruses causing mainly asymptomatic infection, but also…”
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Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer’s disease pathogenesis
Published in Journal of neurovirology (01-10-2015)“…Several data indicate that neuronal infection with herpes simplex virus type 1 (HSV-1) causes biochemical alterations reminiscent of Alzheimer’s disease (AD)…”
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GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition
Published in Frontiers in immunology (06-02-2019)“…An imbalance in GSH/GSSG ratio represents a triggering event in pro-inflammatory cytokine production and inflammatory response. However, the molecular…”
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15
Alport syndrome and leiomyomatosis: the first deletion extending beyond COL4A6 intron 2
Published in Pediatric nephrology (Berlin, West) (01-05-2011)“…Alport syndrome (ATS) is a nephropathy characterized by the association of progressive hematuric nephritis with ultrastructural changes of the glomerular…”
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A Novel Method to Titrate Herpes Simplex Virus-1 (HSV-1) Using Laser-Based Scanning of Near-Infrared Fluorophores Conjugated Antibodies
Published in Frontiers in microbiology (14-06-2017)“…Among several strategies used for Herpes simplex virus (HSV) detection in biological specimens, standard plaque assay (SPA) remains the most reliable method to…”
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MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation
Published in Future medicinal chemistry (01-11-2016)“…Histone deacetylases (HDACs) regulate the life cycle of several viruses. We investigated the ability of different HDAC inhibitors, to interfere with influenza…”
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Corrigendum: GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition
Published in Frontiers in immunology (02-07-2019)“…[This corrects the article DOI: 10.3389/fimmu.2019.00155.]…”
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Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons
Published in Frontiers in aging neuroscience (18-10-2016)“…Several findings suggest that Herpes simplex virus-1 (HSV-1) infection plays a role in the neurodegenerative processes that characterize Alzheimer's disease…”
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Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer’s Disease Progression
Published in Microorganisms (Basel) (01-07-2020)“…Compelling evidence supports the role of oxidative stress in Alzheimer’s disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a…”
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