Search Results - "Marco Mina"

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors by Saghafinia, Sadegh, Mina, Marco, Riggi, Nicolo, Hanahan, Douglas, Ciriello, Giovanni

“…The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate…”
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Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability by Raynaud, Franck, Mina, Marco, Tavernari, Daniele, Ciriello, Giovanni

“…Genomic instability is a major driver of intra-tumor heterogeneity. However, unstable genomes often exhibit different molecular and clinical phenotypes, which…”
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Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression by Tavernari, Daniele, Battistello, Elena, Dheilly, Elie, Petruzzella, Aaron S, Mina, Marco, Sordet-Dessimoz, Jessica, Peters, Solange, Krueger, Thorsten, Gfeller, David, Riggi, Nicolo, Oricchio, Elisa, Letovanec, Igor, Ciriello, Giovanni

“…Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma,…”
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Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes by Liu, Yuanlong, Nanni, Luca, Sungalee, Stephanie, Zufferey, Marie, Tavernari, Daniele, Mina, Marco, Ceri, Stefano, Oricchio, Elisa, Ciriello, Giovanni

“…Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome…”
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Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies by Mina, Marco, Raynaud, Franck, Tavernari, Daniele, Battistello, Elena, Sungalee, Stephanie, Saghafinia, Sadegh, Laessle, Titouan, Sanchez-Vega, Francisco, Schultz, Nikolaus, Oricchio, Elisa, Ciriello, Giovanni

“…Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely…”
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Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers by Zufferey, Marie, Liu, Yuanlong, Tavernari, Daniele, Mina, Marco, Ciriello, Giovanni

“…Spatial interactions and insulation of chromatin regions are associated with transcriptional regulation. Domains of frequent chromatin contacts are proposed as…”
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The functional complex network approach to foster forest resilience to global changes by Messier, Christian, Bauhus, Jürgen, Doyon, Frederik, Maure, Fanny, Sousa-Silva, Rita, Nolet, Philippe, Mina, Marco, Aquilué, Núria, Fortin, Marie-Josée, Puettmann, Klaus

“…Human impacts on Earth’s ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and…”
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AlignNemo: a local network alignment method to integrate homology and topology by Ciriello, Giovanni, Mina, Marco, Guzzi, Pietro H, Cannataro, Mario, Guerra, Concettina

“…Local network alignment is an important component of the analysis of protein-protein interaction networks that may lead to the identification of evolutionary…”
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Editorial: Cancer evolution: From biological insights to therapeutic opportunities by Davis, Andrew A., Gerratana, Lorenzo, Mina, Marco

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A transcribed enhancer dictates mesendoderm specification in pluripotency by Alexanian, Michael, Maric, Daniel, Jenkinson, Stephen P., Mina, Marco, Friedman, Clayton E., Ting, Ching-Chia, Micheletti, Rudi, Plaisance, Isabelle, Nemir, Mohamed, Maison, Damien, Kernen, Jasmin, Pezzuto, Iole, Villeneuve, Dominic, Burdet, Frédéric, Ibberson, Mark, Leib, Stephen L., Palpant, Nathan J., Hernandez, Nouria, Ounzain, Samir, Pedrazzini, Thierry

“…Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer…”
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Contrasting impacts of climate change on protection forests of the Italian Alps by Hillebrand, Laurin, Marzini, Sebastian, Crespi, Alice, Hiltner, Ulrike, Mina, Marco

“…Protection forests play a key role in protecting settlements, people, and infrastructures from gravitational hazards such as rockfalls and avalanches in…”
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Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity by Raynaud, Franck, Mina, Marco, Ciriello, Giovanni

“…Intra-tumor heterogeneity is frequently observed in cancer patients, and it is associated with therapeutic resistance and disease relapse. However, its…”
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A perspective on the need for integrated frameworks linking species distribution and dynamic forest landscape models across spatial scales by Hof, Anouschka R., Mina, Marco, Mairota, Paola, Aguilar, Francisco, Leitinger, Georg, Brůna, Josef, Koivula, Matti, Klopčič, Matija, Sjögren, Jörgen, Vacchiano, Giorgio

“…Climate change significantly alters species distributions. Numerous studies project the future distribution of species using Species Distribution models…”
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Tree regeneration in models of forest dynamics: A key priority for further research by Díaz‐Yáñez, Olalla, Käber, Yannek, Anders, Tim, Bohn, Friedrich, Braziunas, Kristin H., Brůna, Josef, Fischer, Rico, Fischer, Samuel M., Hetzer, Jessica, Hickler, Thomas, Hochauer, Christian, Lexer, Manfred J., Lischke, Heike, Mairota, Paola, Merganič, Ján, Merganičová, Katarina, Mette, Tobias, Mina, Marco, Morin, Xavier, Nieberg, Mats, Rammer, Werner, Reyer, Christopher P. O., Scheiter, Simon, Scherrer, Daniel, Bugmann, Harald

“…Tree regeneration is a key process in forest dynamics, particularly in the context of forest resilience and climate change. Models are pivotal for assessing…”
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Simulating the Effects of Intensifying Silviculture on Desired Species Yields across a Broad Environmental Gradient by Eric B. Searle, F. Wayne Bell, Guy R. Larocque, Mathieu Fortin, Jennifer Dacosta, Rita Sousa-Silva, Marco Mina, Holly D. Deighton

“…In the past two decades, forest management has undergone major paradigm shifts that are challenging the current forest modelling architecture. New…”
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Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells by Mina, Marco, Magi, Shigeyuki, Jurman, Giuseppe, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Arner, Erik, Forrest, Alistair R. R., Carninci, Piero, Hayashizaki, Yoshihide, Daub, Carsten O., Okada-Hatakeyama, Mariko, Furlanello, Cesare

“…The analysis of CAGE (Cap Analysis of Gene Expression) time-course has been proposed by the FANTOM5 Consortium to extend the understanding of the sequence of…”
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Novel therapeutic strategy in the management of COPD: a systems medicine approach by Lococo, Filippo, Cesario, Alfredo, Del Bufalo, Alessandra, Ciarrocchi, Alessia, Prinzi, Giulia, Mina, Marco, Bonassi, Stefano, Russo, Patrizia

“…Respiratory diseases including chronic-obstructive-pulmonary-disease (COPD) are globally increasing, with COPD predicted to become the third leading cause of…”
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A harmonized database of European forest simulations under climate change by Grünig, Marc, Rammer, Werner, Albrich, Katharina, André, Frédéric, Augustynczik, Andrey L.D., Bohn, Friedrich, Bouwman, Meike, Bugmann, Harald, Collalti, Alessio, Cristal, Irina, Dalmonech, Daniela, De Caceres, Miquel, De Coligny, Francois, Dobor, Laura, Dollinger, Christina, Forrester, David I., Garcia-Gonzalo, Jordi, González, José Ramón, Hiltner, Ulrike, Hlásny, Tomáš, Honkaniemi, Juha, Huber, Nica, Jonard, Mathieu, Maria Jönsson, Anna, Lagergren, Fredrik, Nieberg, Mats, Mina, Marco, Mohren, Frits, Moos, Christine, Morin, Xavier, Muys, Bart, Peltoniemi, Mikko, Reyer, Christopher PO, Storms, Ilié, Thom, Dominik, Toïgo, Maude, Seidl, Rupert

“…Process-based forest models combine biological, physical, and chemical process understanding to simulate forest dynamics as an emergent property of the system…”
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A Step-by-Step Guide to Initialize and Calibrate Landscape Models: A Case Study in the Mediterranean Mountains by Suárez-Muñoz, María, Mina, Marco, Salazar, Pablo C., Navarro-Cerrillo, Rafael M., Quero, José L., Bonet-García, Francisco J.

“…The use of spatially interactive forest landscape models has increased in recent years. These models are valuable tools to assess our knowledge about the…”
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Corrigendum: A Step-By-Step Guide to Initialize and Calibrate Landscape Models: A Case Study in the Mediterranean Mountains by Suárez-Muñoz, María, Mina, Marco, Salazar, Pablo C., Navarro-Cerrillo, Rafael M., Quero, José L., Bonet-García, Francisco J.

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