Search Results - "Marco Ghezzi"
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Mutational screening of NR5A1 gene encoding steroidogenic factor 1 in cryptorchidism and male factor infertility and functional analysis of seven undescribed mutations
Published in Fertility and sterility (01-07-2015)“…Objective To study the role of NR5A1 in cryptorchidism and male factor infertility. Mutations in NR5A1 have been initially associated with primary adrenal…”
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Spontaneous fertility and in vitro fertilization outcome: new evidence of human papillomavirus sperm infection
Published in Fertility and sterility (2016)“…Objective To evaluate the reproductive outcome of infertile couples undergoing assisted reproduction techniques (ART) with or without human papillomavirus…”
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Testicular Cancer: Genes, Environment, Hormones
Published in Frontiers in endocrinology (Lausanne) (02-07-2019)“…Testicular cancer (TC) represents one of the most peculiar clinical challenges at present. In fact, currently treatments are so effective ensuring a 5 years…”
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Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure
Published in The journal of clinical endocrinology and metabolism (01-03-2016)“…Context: The G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis…”
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Role of Viral Infections in Testicular Cancer Etiology: Evidence From a Systematic Review and Meta-Analysis
Published in Frontiers in endocrinology (Lausanne) (12-06-2019)“…The most represented histotype of testicular cancer is the testicular germ-cell tumor (TGCT), both seminoma and non-seminoma. The pathogenesis of this cancer…”
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Fertility Outcomes and Sperm-DNA Parameters in Metastatic Melanoma Survivors Receiving Vemurafenib or Dabrafenib Therapy: Case Report
Published in Frontiers in oncology (05-03-2020)“…Melanoma is a frequent neoplasm in young adult males in reproductive age, 10% of them degenerating into regional and/or distant metastases (MM). The use of…”
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Evaluation of Serum/Urine Genomic and Metabolomic Profiles to Improve the Adherence to Sildenafil Therapy in Patients with Erectile Dysfunction
Published in Frontiers in pharmacology (10-12-2020)“…Type V-phosphodiesterase-inhibitors (PDE5i) are the first choice drugs in the treatment of erectile dysfunction (ED), being effective in 60-70% of patients…”
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HPV Prophylactic Vaccination in Males Improves the Clearance of Semen Infection
Published in EBioMedicine (01-10-2015)“…Semen represents a reservoir for human papillomavirus (HPV), rising concern in couples eligible for assisted reproduction techniques (ART). Humoral immunity…”
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Serum Anti-HPV Antibody Titer as a Marker of Vaccine Effectiveness in Males with Genital Infection
Published in Vaccines (Basel) (07-12-2020)“…Persistent human papillomavirus (HPV) semen infection is increasingly associated with male infertility. Adjuvant HPV vaccination is suggested to reduce the…”
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Comparison of NGS panel and Sanger sequencing for genotyping CAG repeats in the AR gene
Published in Molecular genetics & genomic medicine (01-06-2020)“…Background The androgen receptor (AR) is a nuclear receptor, encoded by the AR gene on the X chromosome. Within the first exon of the AR gene, two short tandem…”
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Sperm Count and Hypogonadism as Markers of General Male Health
Published in European urology focus (01-01-2021)“…Some evidence suggests that infertile men, who are at increased risk for hypogonadism, metabolic derangements, and osteoporosis, have higher long-term…”
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Negative Association Between Sclerostin and INSL3 in Isolated Human Osteocytes and in Klinefelter Syndrome: New Hints for Testis–Bone Crosstalk
Published in The journal of clinical endocrinology and metabolism (01-05-2018)“…The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insulin-like 3 peptide (INSL3) on the most…”
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FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate
Published in Endocrine (01-05-2017)“…The purpose of this study is to evaluate whether follicle-stimulating hormone treatment improves sperm DNA parameters and pregnancy outcome in infertile male…”
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Development of a novel next-generation sequencing panel for diagnosis of quantitative spermatogenic impairment
Published in Journal of assisted reproduction and genetics (01-04-2020)“…Purpose To develop and assess a novel custom next-generation sequencing (NGS) panel for male infertility genetic diagnosis. Methods A total of 241 subjects…”
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Copy number variations of E2F1: a new genetic risk factor for testicular cancer
Published in Endocrine-related cancer (01-03-2017)“…Testicular germ cell tumor (TGCT) is one of the most heritable forms of cancer. In last years, many evidence suggested that constitutional genetic factors,…”
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Molecular karyotyping of single sperm with nuclear vacuoles identifies more chromosomal abnormalities in patients with testiculopathy than fertile controls: implications for ICSI
Published in Human reproduction (Oxford) (01-11-2015)“…STUDY QUESTION Is there a difference between molecular karyotype of single sperm selected by high-magnification microscopy from infertile patients with…”
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No Difference in 5-HTTLPR and Stin2 Polymorphisms Frequency Between Premature Ejaculation Patients and Controls
Published in Journal of sexual medicine (01-06-2012)“…Premature ejaculation (PE) is defined as the inability of men to control ejaculation and it is the most prevalent male sexual dysfunction. The neurobiogenesis…”
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Calcium-sensing receptor polymorphisms increase the risk of osteoporosis in ageing males
Published in Endocrine (01-08-2018)Get full text
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Increased risk of testis failure in testicular germ cell tumor survivors undergoing radiotherapy
Published in Oncotarget (09-01-2018)“…Testicular germ cell tumors (TGCTs) are prevalent in males of reproductive age. Among the available therapeutic choices, pelvic radiotherapy (RT) and simple…”
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Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor
Published in Frontiers in pharmacology (13-05-2016)“…Young males have testicular germ cells tumors (TGCT) as the most common malignancy and its incidence is increasing in several countries. Besides unilateral…”
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