Search Results - "Marco, Y"

The Perseus computational platform for comprehensive analysis of (prote)omics data by Tyanova, Stefka, Temu, Tikira, Sinitcyn, Pavel, Carlson, Arthur, Hein, Marco Y, Geiger, Tamar, Mann, Matthias, Cox, Jürgen

“…Perseus is a comprehensive, user-friendly software platform for the biological analysis of quantitative proteomics data. It is intended to help biologists with…”
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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ by Cox, Jürgen, Hein, Marco Y., Luber, Christian A., Paron, Igor, Nagaraj, Nagarjuna, Mann, Matthias

“…Protein quantification without isotopic labels has been a long-standing interest in the proteomics field. However, accurate and robust proteome-wide…”
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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances by Hein, Marco Y., Hubner, Nina C., Poser, Ina, Cox, Jürgen, Nagaraj, Nagarjuna, Toyoda, Yusuke, Gak, Igor A., Weisswange, Ina, Mansfeld, Jörg, Buchholz, Frank, Hyman, Anthony A., Mann, Matthias

“…The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the…”
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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation by Patel, Avinash, Lee, Hyun O., Jawerth, Louise, Maharana, Shovamayee, Jahnel, Marcus, Hein, Marco Y., Stoynov, Stoyno, Mahamid, Julia, Saha, Shambaditya, Franzmann, Titus M., Pozniakovski, Andrej, Poser, Ina, Maghelli, Nicola, Royer, Loic A., Weigert, Martin, Myers, Eugene W., Grill, Stephan, Drechsel, David, Hyman, Anthony A., Alberti, Simon

“…Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study…”
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Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD by Reeves, Helen L., Zaki, Marco Y. W., Day, Christopher P.

“…Hepatocellular carcinoma (HCC) is the second commonest cause of cancer death worldwide. Rather than falling as a result of prevention and treatments for viral…”
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A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards by Wiśniewski, Jacek R., Hein, Marco Y., Cox, Jürgen, Mann, Matthias

“…Absolute protein quantification using mass spectrometry (MS)-based proteomics delivers protein concentrations or copy numbers per cell. Existing methodologies…”
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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility by Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.

“…Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the…”
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Functional single-cell genomics of human cytomegalovirus infection by Hein, Marco Y., Weissman, Jonathan S.

“…Understanding how viral and host factors interact and how perturbations impact infection is the basis for designing antiviral interventions. Here we define the…”
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Accurate Protein Complex Retrieval by Affinity Enrichment Mass Spectrometry (AE-MS) Rather than Affinity Purification Mass Spectrometry (AP-MS) by Keilhauer, Eva C., Hein, Marco Y., Mann, Matthias

“…Protein–protein interactions are fundamental to the understanding of biological processes. Affinity purification coupled to mass spectrometry (AP-MS) is one of…”
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Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool by Vahl, J. Christoph, Drees, Christoph, Heger, Klaus, Heink, Sylvia, Fischer, Julius C., Nedjic, Jelena, Ohkura, Naganari, Morikawa, Hiromasa, Poeck, Hendrik, Schallenberg, Sonja, Rieß, David, Hein, Marco Y., Buch, Thorsten, Polic, Bojan, Schönle, Anne, Zeiser, Robert, Schmitt-Gräff, Annette, Kretschmer, Karsten, Klein, Ludger, Korn, Thomas, Sakaguchi, Shimon, Schmidt-Supprian, Marc

“…Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately…”
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A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response by Adamson, Britt, Norman, Thomas M., Jost, Marco, Cho, Min Y., Nuñez, James K., Chen, Yuwen, Villalta, Jacqueline E., Gilbert, Luke A., Horlbeck, Max A., Hein, Marco Y., Pak, Ryan A., Gray, Andrew N., Gross, Carol A., Dixit, Atray, Parnas, Oren, Regev, Aviv, Weissman, Jonathan S.

“…Functional genomics efforts face tradeoffs between number of perturbations examined and complexity of phenotypes measured. We bridge this gap with Perturb-seq,…”
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Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism by Saha, Shambaditya, Weber, Christoph A., Nousch, Marco, Adame-Arana, Omar, Hoege, Carsten, Hein, Marco Y., Osborne-Nishimura, Erin, Mahamid, Julia, Jahnel, Marcus, Jawerth, Louise, Pozniakovski, Andrej, Eckmann, Christian R., Jülicher, Frank, Hyman, Anthony A.

“…P granules are non-membrane-bound RNA-protein compartments that are involved in germline development in C. elegans. They are liquids that condense at one end…”
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Early and Extreme Warming in the South China Sea During 2015/2016: Role of an Unusual Indian Ocean Dipole Event by Xiao, Fuan, Wang, Dongxiao, Leung, Marco Y. T.

“…The South China Sea (SCS) experienced sea surface temperature that broke historical records in the autumn of 2015. This event cannot be explained by El Niño…”
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Phase relationship between summer and winter monsoons over the South China Sea: Indian Ocean and ENSO forcing by Zhang, Yue, Zhou, Wen, Leung, Marco Y. T.

“…This paper identifies the seasonal relationships between monsoon activities over South China (SC) in winter and summer, which can help improve seasonal…”
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Association of air pollution and weather conditions during infection course with COVID-19 case fatality rate in the United Kingdom by Hossain, M. Pear, Zhou, Wen, Leung, Marco Y. T., Yuan, Hsiang-Yu

“…Although the relationship between the environmental factors, such as weather conditions and air pollution, and COVID-19 case fatality rate (CFR) has been…”
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OpenCell: Endogenous tagging for the cartography of human cellular organization by Cho, Nathan H, Cheveralls, Keith C, Brunner, Andreas-David, Kim, Kibeom, Michaelis, André C, Raghavan, Preethi, Kobayashi, Hirofumi, Savy, Laura, Li, Jason Y, Canaj, Hera, Kim, James Y S, Stewart, Edna M, Gnann, Christian, McCarthy, Frank, Cabrera, Joana P, Brunetti, Rachel M, Chhun, Bryant B, Dingle, Greg, Hein, Marco Y, Huang, Bo, Mehta, Shalin B, Weissman, Jonathan S, Gómez-Sjöberg, Rafael, Itzhak, Daniel N, Royer, Loïc A, Mann, Matthias, Leonetti, Manuel D

“…Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass…”
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MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices by McGinnis, Christopher S., Patterson, David M., Winkler, Juliane, Conrad, Daniel N., Hein, Marco Y., Srivastava, Vasudha, Hu, Jennifer L., Murrow, Lyndsay M., Weissman, Jonathan S., Werb, Zena, Chow, Eric D., Gartner, Zev J.

“…Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such as cell doublets. However, universal and scalable sample barcoding…”
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Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease by Younes, Ramy, Caviglia, Gian Paolo, Govaere, Olivier, Rosso, Chiara, Armandi, Angelo, Sanavia, Tiziana, Pennisi, Grazia, Liguori, Antonio, Francione, Paolo, Gallego-Durán, Rocío, Ampuero, Javier, Garcia Blanco, Maria J., Aller, Rocio, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio M., Maggioni, Marco, Cabibi, Daniela, Pareja, María Jesús, Zaki, Marco Y.W., Grieco, Antonio, Fracanzani, Anna L., Valenti, Luca, Miele, Luca, Fariselli, Piero, Petta, Salvatore, Romero-Gomez, Manuel, Anstee, Quentin M., Bugianesi, Elisabetta

“…Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their…”
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Decoding Human Cytomegalovirus by Stern-Ginossar, Noam, Weisburd, Ben, Michalski, Annette, Le, Vu Thuy Khanh, Hein, Marco Y., Huang, Sheng-Xiong, Ma, Ming, Shen, Ben, Qian, Shu-Bing, Hengel, Hartmut, Mann, Matthias, Ingolia, Nicholas T., Weissman, Jonathan S.

“…The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like those of other complex viruses, our understanding of its protein coding…”
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TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms by Esparza-Baquer, Aitor, Labiano, Ibone, Sharif, Omar, Agirre-Lizaso, Aloña, Oakley, Fiona, Rodrigues, Pedro M, Zhuravleva, Ekaterina, O'Rourke, Colm J, Hijona, Elizabeth, Jimenez-Agüero, Raul, Riaño, Ioana, Landa, Ana, La Casta, Adelaida, Zaki, Marco Y W, Munoz-Garrido, Patricia, Azkargorta, Mikel, Elortza, Felix, Vogel, Andrea, Schabbauer, Gernot, Aspichueta, Patricia, Andersen, Jesper B, Knapp, Sylvia, Mann, Derek A, Bujanda, Luis, Banales, Jesus Maria, Perugorria, Maria Jesus

“…Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic…”
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