Search Results - "Marco, Michael R"

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix by Kim, Jin K., Marco, Michael R., Choi, Seo‐Hyun, Qu, Xuan, Chen, Chin‐Tung, Elkabets, Moshe, Fairchild, Lauren, Chow, Oliver, Barriga, Francisco M., Dow, Lukas E., O’Rourke, Kevin, Szeglin, Bryan, Yarilin, Dmitry, Fujisawa, Sho, Manova‐Todorova, Katia, Paty, Philip B., Shia, Jinru, Leslie, Christina, Joshua Smith, J., Lowe, Scott, Pelossof, Raphael, Sanchez‐Vega, Francisco, Garcia‐Aguilar, Julio

“…Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully…”
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A SMAD4‐modulated gene profile predicts disease‐free survival in stage II and III colorectal cancer by Szeglin, Bryan C., Wu, Chao, Marco, Michael R., Park, Hyun Sung, Zhang, Zeda, Zhang, Bing, Garcia‐Aguilar, Julio, Beauchamp, R. Daniel, Chen, X. Steven, Smith, J. Joshua

“…Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in the United States and a leading cause of cancer‐related mortality…”
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Consolidation mFOLFOX6 Chemotherapy After Chemoradiotherapy Improves Survival in Patients With Locally Advanced Rectal Cancer: Final Results of a Multicenter Phase II Trial by Marco, Michael R, Zhou, Lihong, Patil, Sujata, Marcet, Jorge E, Varma, Madhulika G, Oommen, Samuel, Cataldo, Peter A, Hunt, Steven R, Kumar, Anjali, Herzig, Daniel O, Fichera, Alessandro, Polite, Blase N, Hyman, Neil H, Ternent, Charles A, Stamos, Michael J, Pigazzi, Alessio, Dietz, David, Yakunina, Yuliya, Pelossof, Raphael, Garcia-Aguilar, Julio

“…BACKGROUND:Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery…”
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Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer by Chatila, Walid K., Kim, Jin K., Walch, Henry, Marco, Michael R., Chen, Chin-Tung, Wu, Fan, Omer, Dana M., Khalil, Danny N., Ganesh, Karuna, Qu, Xuan, Luthra, Anisha, Choi, Seo-Hyun, Ho, Yu-Jui, Kundra, Ritika, Groves, Katharine I., Chow, Oliver S., Cercek, Andrea, Weiser, Martin R., Widmar, Maria, Wei, Iris H., Pappou, Emmanouil P., Nash, Garrett M., Paty, Philip B., Shi, Qian, Vakiani, Efsevia, Duygu Selcuklu, S., Donoghue, Mark T. A., Solit, David B., Berger, Michael F., Shia, Jinru, Pelossof, Raphael, Romesser, Paul B., Yaeger, Rona, Smith, J. Joshua, Schultz, Nikolaus, Sanchez-Vega, Francisco, Garcia-Aguilar, Julio

“…The incidence of rectal cancer is increasing in patients younger than 50 years. Locally advanced rectal cancer is still treated with neoadjuvant radiation,…”
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SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance by Wasserman, Isaac, Lee, Lik Hang, Ogino, Shuji, Marco, Michael R, Wu, Chao, Chen, Xi, Datta, Jashodeep, Sadot, Eran, Szeglin, Bryan, Guillem, Jose G, Paty, Philip B, Weiser, Martin R, Nash, Garrett M, Saltz, Leonard, Barlas, Afsar, Manova-Todorova, Katia, Uppada, Srijaya Prakash Babu, Elghouayel, Arthur E, Ntiamoah, Peter, Glickman, Jonathan N, Hamada, Tsuyoshi, Kosumi, Keisuke, Inamura, Kentaro, Chan, Andrew T, Nishihara, Reiko, Cercek, Andrea, Ganesh, Karuna, Kemeny, Nancy E, Dhawan, Punita, Yaeger, Rona, Sawyers, Charles L, Garcia-Aguilar, Julio, Giannakis, Marios, Shia, Jinru, Smith, J Joshua

“…SMAD4 has shown promise in identifying patients with colorectal cancer at high risk of recurrence or death. A discovery cohort and independent validation…”
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KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer by Choi, Seo-Hyun, Kim, Jin K, Chen, Chin-Tung, Wu, Chao, Marco, Michael R, Barriga, Francisco M, O'Rourke, Kevin, Pelossof, Raphael, Qu, Xuan, Chang, Qing, de Stanchina, Elisa, Shia, Jinru, Smith, J Joshua, Sanchez-Vega, Francisco, Garcia-Aguilar, Julio

“…KRAS mutation in colorectal cancer is associated with aggressive tumor behavior through increased invasiveness and higher rates of lung metastases, but the…”
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Survival After Induction Chemotherapy and Chemoradiation Versus Chemoradiation and Adjuvant Chemotherapy for Locally Advanced Rectal Cancer by Kim, Jin K, Marco, Michael R, Roxburgh, Campbell S D, Chen, Chin-Tung, Cercek, Andrea, Strombom, Paul, Temple, Larissa K F, Nash, Garrett M, Guillem, Jose G, Paty, Philip B, Yaeger, Rona, Stadler, Zsofia K, Gonen, Mithat, Segal, Neil H, Reidy, Diane L, Varghese, Anna, Shia, Jinru, Vakiani, Efsevia, Wu, Abraham J, Romesser, Paul B, Crane, Christopher H, Gollub, Marc J, Saltz, Leonard, Smith, J Joshua, Weiser, Martin R, Patil, Sujata, Garcia-Aguilar, Julio

“…Total neoadjuvant therapy (TNT) improves tumor response in locally advanced rectal cancer (LARC) patients compared to neoadjuvant chemoradiotherapy alone. The…”
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A rectal cancer organoid platform to study individual responses to chemoradiation by Ganesh, Karuna, Wu, Chao, O’Rourke, Kevin P., Szeglin, Bryan C., Zheng, Youyun, Sauvé, Charles-Etienne Gabriel, Adileh, Mohammad, Wasserman, Isaac, Marco, Michael R., Kim, Amanda S., Shady, Maha, Sanchez-Vega, Francisco, Karthaus, Wouter R., Won, Helen H., Choi, Seo-Hyun, Pelossof, Raphael, Barlas, Afsar, Ntiamoah, Peter, Pappou, Emmanouil, Elghouayel, Arthur, Strong, James S., Chen, Chin-Tung, Harris, Jennifer W., Weiser, Martin R., Nash, Garrett M., Guillem, Jose G., Wei, Iris H., Kolesnick, Richard N., Veeraraghavan, Harini, Ortiz, Eduardo J., Petkovska, Iva, Cercek, Andrea, Manova-Todorova, Katia O., Saltz, Leonard B., Lavery, Jessica A., DeMatteo, Ronald P., Massagué, Joan, Paty, Philip B., Yaeger, Rona, Chen, Xi, Patil, Sujata, Clevers, Hans, Berger, Michael F., Lowe, Scott W., Shia, Jinru, Romesser, Paul B., Dow, Lukas E., Garcia-Aguilar, Julio, Sawyers, Charles L., Smith, J. Joshua

“…Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation and surgery to optimize outcomes for individual patients. No…”
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MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer by Williams, Hannah, Omer, Dana M, Thompson, Hannah M, Lin, Sabrina T, Verheij, Floris S, Miranda, Joao, Yuval, Jonathan B, Buckley, James, Marco, Michael R, Qin, Li-Xuan, Dombroski, David A, Kedar, Rajendra, Oto, Aytekin, Korngold, Elena, Veniero, Joseph C, Gandhi, Sunil, Krishnaraj, Arun, Jagtiani, Minal, Ohanian, Kirk, Vu, Dan, Hope, Thomas A, Lee, Sonia, Wasnik, Ashish P, Madhuripan, Nikhil, Gollub, Marc J, Garcia-Aguilar, Julio

“…Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have…”
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