Search Results - "Marciani, Dante"

Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants by Marciani, Dante J.

“…Numerous triterpenoid saponins are adjuvants that modify the activities of T cells and antigen-presenting cells, like dendritic cells (DCs). Saponins can…”
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Effects of N-acylation on the immune adjuvanticity of analogs of the Quillaja saponins derivative GPI-0100 by Marciani, Dante J.

“…•Lipophilic alkyl chains alter Q. saponins’ conformation and associative properties.•Q. saponins’ micellar properties may affect the availability of certain…”
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A retrospective analysis of the Alzheimer's disease vaccine progress – The critical need for new development strategies by Marciani, Dante J.

“…The promising results obtained with aducanumab and solanezumab against Alzheimer's disease (AD) strengthen the vaccine approach to prevent AD, despite of the…”
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Alzheimer's disease vaccine development: A new strategy focusing on immune modulation by Marciani, Dante J

“…Abstract Despite significant advances in the development of Alzheimer's disease (AD) vaccines effective in animal models, these prototypes have been clinically…”
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New Th2 adjuvants for preventive and active immunotherapy of neurodegenerative proteinopathies by Marciani, Dante J.

“…•Vaccine therapy of neurodegenerative proteopathies solely requires Th2 immunity.•Explaining the paradox of the AN-1792 Alzheimer's disease vaccine…”
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Is fucose the answer to the immunomodulatory paradox of Quillaja saponins? by Marciani, Dante J.

“…Quillaja saponins, e.g. QS-21, are immunomodulating aldehyde-carrying triterpene glycosides, which depending on the acylation state of their single fucosyl…”
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Rejecting the Alzheimer's disease vaccine development for the wrong reasons by Marciani, Dante J.

“…•Tested Alzheimer vaccines were more suited for transgenic mouse models than humans.•Immunogen must have the conformational epitope found in toxic oligomeric…”
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Effects of immunomodulators on the response induced by vaccines against autoimmune diseases by Marciani, Dante J.

“…A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an…”
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Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity by Marciani, Dante J.

“…Inactivated vaccines require adjuvants to stimulate an immune response. The choice of adjuvant or immune enhancer determines whether the immune response is…”
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Facing Alzheimer’s disease in the developing countries by Marciani, Dante J.

“…Aunque el incremento de casos de enfermedad de Alzheimer (EA) en los países desarrollados será limitado, en los países en desarrollo de América Latina, Asia y…”
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Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100 by Marciani, Dante J, Reynolds, Robert C, Pathak, Ashish K, Finley-Woodman, Kyra, May, Richard D

“…Unfractionated GPI-0100 (UFGPI-0100) containing semi-synthetic derivatives of deacylated Quillaja saponins (DS saponins) modified at the glucuronic acid…”
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Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2 by Quenelle, Debra C., Collins, Deborah J., Marciani, Dante J., Kern, Earl R.

“…These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1…”
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Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs by Quenelle, Debra C., Collins, Deborah J., Rice, Terri L., Prichard, Mark N., Marciani, Dante J., Kern, Earl R.

“…These studies were performed to determine the effect of AD-472, an attenuated human herpes simplex virus (HSV) type 2 or HSV-2 glycoprotein D (gD) when…”
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Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins by Marciani, Dante J., Pathak, Ashish K., Reynolds, Robert C., Seitz, Lainne, May, Richard D.

“…Quillaja saponins are readily hydrolyzed under physiological conditions, yielding deacylated forms that are significantly less toxic than their precursors…”
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Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis by Zhang, Ping, Yang, Qiu-Bo, Marciani, Dante J, Martin, Michael, Clements, John D, Michalek, Suzanne M, Katz, Jannet

“…The gram-negative, anaerobic bacterium Porphyromonas gingivalis, has been implicated in the etiology of adult periodontal disease. Among the potential…”
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Quillaja saponin adjuvants: derivatives formed under sub-optimal conditions by Marciani, Dante J, Pathak, Ashish K, Reynolds, Robert D

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Alzheimer’s disease: Toward the rational design of an effective vaccine by Marciani, Dante J.

“…The promising clinical results with the human monoclonal antibodies aducanumab and solanezumab targeting β-amyloidin Alzheimer’s disease treatment, confirm…”
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Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine by Marciani, Dante J, Ptak, Roger G, Voss, Thomas G, Reynolds, Robert C, Pathak, Ashish K, Chamblin, Tyler L, Scholl, David R, May, Richard D

“…Quillaja saponins (Q. saponins) are readily hydrolyzed at neutral pH to yield degraded deacylated saponins (DS-saponins). Degradation of Q. saponins resulted…”
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The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health by Lowry, Christopher A., Smith, David G., Siebler, Philip H., Schmidt, Dominic, Stamper, Christopher E., Hassell, James E., Yamashita, Paula S., Fox, James H., Reber, Stefan O., Brenner, Lisa A., Hoisington, Andrew J., Postolache, Teodor T., Kinney, Kerry A., Marciani, Dante, Hernandez, Mark, Hemmings, Sian M. J., Malan-Muller, Stefanie, Wright, Kenneth P., Knight, Rob, Raison, Charles L., Rook, Graham A. W.

“…The hygiene or “Old Friends” hypothesis proposes that the epidemic of inflammatory disease in modern urban societies stems at least in part from reduced…”
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Synergistic Effects of Immune Agonists on Efficacy of Vaccines by Marciani, Dante J, Triozzi, Pierre L

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