Search Results - "Marchica, Valentina"
-
1
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Published in Blood (04-08-2016)“…The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has…”
Get full text
Journal Article -
2
Oncolytic Virotherapy and Microenvironment in Multiple Myeloma
Published in International journal of molecular sciences (24-02-2021)“…Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of bone marrow (BM) clonal plasma cells, which are strictly dependent on…”
Get full text
Journal Article -
3
Role of Galectins in Multiple Myeloma
Published in International journal of molecular sciences (17-12-2017)“…Galectins are a family of lectins that bind β-galactose-containing glycoconjugates and are characterized by carbohydrate-recognition domains (CRDs). Galectins…”
Get full text
Journal Article -
4
ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma
Published in Cancer cell (10-07-2017)“…Amplification of 1q21 occurs in approximately 30% of de novo and 70% of relapsed multiple myeloma (MM) and is correlated with disease progression and drug…”
Get full text
Journal Article -
5
CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy
Published in British journal of haematology (01-08-2020)“…Summary A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients…”
Get full text
Journal Article -
6
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy
Published in Nature medicine (01-03-2022)“…Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of hematopoietic stem cells (HSCs). The current standard of care for patients with MDS…”
Get full text
Journal Article -
7
A Simplified SARS-CoV-2 Pseudovirus Neutralization Assay
Published in Vaccines (Basel) (15-04-2021)“…COVID-19 is an ongoing pandemic caused by the highly infectious coronavirus SARS-CoV-2 that is engaging worldwide scientific research to find a timely and…”
Get full text
Journal Article -
8
Molecular Features of the Mesenchymal and Osteoblastic Cells in Multiple Myeloma
Published in International journal of molecular sciences (07-12-2022)“…Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow…”
Get full text
Journal Article -
9
The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors
Published in Journal of bone and mineral research (01-04-2016)“…ABSTRACT Multiple myeloma (MM) is characterized by severely imbalanced bone remodeling. In this study, we investigated the potential effect of proteasome…”
Get full text
Journal Article -
10
Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development
Published in Frontiers in cellular neuroscience (03-01-2024)“…Angiopoietin 1 (angpt1) is essential for angiogenesis. However, its role in neurogenesis is largely undiscovered. This study aimed to identify the role of…”
Get full text
Journal Article -
11
-
12
Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease
Published in Frontiers in oncology (13-10-2022)“…Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells (PCs) into the bone marrow (BM). The complex…”
Get full text
Journal Article -
13
Mechanisms of Action of the New Antibodies in Use in Multiple Myeloma
Published in Frontiers in oncology (08-07-2021)“…Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM) cells have Fc-dependent immune effector mechanisms, such as…”
Get full text
Journal Article -
14
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma
Published in Nature communications (08-02-2024)“…DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA…”
Get full text
Journal Article -
15
Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response
Published in Oncoimmunology (31-12-2022)“…The humoral and cellular response to SARS-CoV-2 mRNA full vaccination and booster dose as well as the impact of the spike variants, including Omicron, are…”
Get full text
Journal Article -
16
PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients
Published in Frontiers in immunology (08-01-2021)“…The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use…”
Get full text
Journal Article -
17
-
18
Author Correction: Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy
Published in Nature medicine (01-05-2022)Get full text
Journal Article -
19
Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets
Published in Cells (Basel, Switzerland) (01-06-2021)“…Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The amplification of 1q21 is one of the most…”
Get full text
Journal Article -
20
IL21R expressing CD14 + CD16 + monocytes expand in multiple myeloma patients leading to increased osteoclasts
Published in Haematologica (Roma) (01-04-2017)“…Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present…”
Get full text
Journal Article