Surface treatment of polycarbonate films aimed at biomedical application

Aiming to encapsulate pancreatic islets, a biocompatible polycarbonate membrane (What-man) was treated with plasma argon in order to improve its surface properties. The argon plasma treatment decreased the hydrophobicity of the membrane by fixing polyvinylpyrrolidone (PVP) at the surface. The water...

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Bibliographic Details
Published in:	Journal of biomaterials science. Polymer ed. Vol. 14; no. 10; pp. 1135 - 1153
Main Authors:	Kessler, Laurence, Legeay, Gilbert, Coudreuse, Arnaud, Bertrand, Patrick, Poleunus, Claude, Eynde, Xavier Vanden, Mandes, Karim, Marchetti, Pierro, Pinget, Michel, Belcourt, Alain
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 01-01-2003
Subjects:	Animals Argon - chemistry Biocompatible Materials - chemistry Diffusion ENCAPSULATION Glucose - pharmacokinetics Islets of Langerhans Transplantation - instrumentation Islets of Langerhans Transplantation - methods Male Materials Testing Membranes, Artificial Microscopy, Atomic Force Microscopy, Electron, Scanning PANCREATIC ISLET Permeability PLASMA TREATMENT POLYCARBONATE MEMBRANE Polycarboxylate Cement - chemistry Povidone - chemistry Rats Rats, Wistar Spectrometry, Mass, Secondary Ion - methods Spectrometry, X-Ray Emission Surface Properties
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Summary:	Aiming to encapsulate pancreatic islets, a biocompatible polycarbonate membrane (What-man) was treated with plasma argon in order to improve its surface properties. The argon plasma treatment decreased the hydrophobicity of the membrane by fixing polyvinylpyrrolidone (PVP) at the surface. The water angle contact decreased from 47° to 20° after this treatment, while the structure and pore diameter were preserved. The treatment also increased significantly the water permeability from 62 ± 8 ml/min to 200 ± 29 ml/min (P < 0.001). ToF-SIMS analyses revealed that the argon plasma treatment of the membrane allowed the installation of an uniform PVP layer at the surface. The concentration equilibrum in glucose was reached after 8 h diffusion for the treated membrane, while it was only 32.4 ± 8.6% (P < 0.01) for the untreated membrane. The biocompatibility of the polycarbonate membrane was assessed after one month of implantation in rats and proved to be unaffected by the surface treatment. In conclusion, the present study provided sufficient information to establish a relationship between the physicochemical modifications of the PVP-plasma-treated polycarbonate membrane and the improvement in its permeability.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0920-5063 1568-5624
DOI:	10.1163/156856203769231619