Search Results - "Marcheselli, V L"

Neuroprotectin D1: A Docosahexaenoic Acid-Derived Docosatriene Protects Human Retinal Pigment Epithelial Cells from Oxidative Stress by Mukherjee, Pranab K., Marcheselli, Victor L., Serhan, Charles N., Bazan, Nicolas G., Fischer, Edmond H.

“…Docosahexaenoic acid (DHA) is a lipid peroxidation target in oxidative injury to retinal pigment epithelium (RPE) and retina. Photoreceptor and synaptic…”
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Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex by MARCHESELLI, V. L, ROSSOWSKA, M. J, DOMINGO, M.-T, BRAQUET, P, BAZAN, N. G

“…The binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC or PAF, platelet-activating factor) to synaptic plasma membranes, microsomal membranes,…”
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Platelet-activating factor is a messenger in the electroconvulsive shock-induced transcriptional activation of c-fos and zif-268 in hippocampus by Marcheselli, V L, Bazan, N G

“…Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), undetectable in resting neural tissue, accumulates in brain during seizures…”
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Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression by Marcheselli, Victor L., Hong, Song, Lukiw, Walter J., Tian, Xiao Hua, Gronert, Karsten, Musto, Alberto, Hardy, Mattie, Gimenez, Juan M., Chiang, Nan, Serhan, Charles N., Bazan, Nicolas G.

“…Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major…”
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Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids by Gerashchenko, DY, Beuckmann, CT, Marcheselli, VL, Gordon, WC, Kanaoka, Y, Eguchi, N, Urade, Y, Hayaishi, O, Bazan, NG

“…Prostaglandin (PG) D synthase is present in neural tissues and cerebrospinal fluid (beta-trace). This enzyme belongs to the lipocalin family which consists of…”
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KID-1, a Protein Kinase Induced by Depolarization in Brain by Feldman, J D, Vician, L, Crispino, M, Tocco, G, Marcheselli, V L, Bazan, N G, Baudry, M, Herschman, H R

“…Membrane depolarization leads to changes in gene expression that modulate neuronal plasticity. Using representational difference analysis, we have identified a…”
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Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury by Panetta, T, Marcheselli, V L, Braquet, P, Spinnewyn, B, Bazan, N G

“…The effects of a platelet activating factor antagonist (BN 52021) on cerebral ischemia-reperfusion was studied in the gerbil. Following ten minutes of…”
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Platelet‐activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: Intracellular PAF‐binding sites and activation of a fos/jun/AP‐1 transcriptional signaling system by Bazan, Nicolas G., Squinto, Stephen P., Braquet, Pierre, Panetta, Thomas, Marcheselli, Victor L.

“…Platelet‐activating factor (PAF) is a lipid mediator formed in the early response of the central nervous system to ischemia or convulsions. Free…”
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Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist by Marcheselli, V L, Bazan, N G

“…Prostaglandin G/H synthase-2 and zif-268 mRNA expression is transiently induced in rat brain by kainic acid (KA)-induced seizures and by a single…”
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Experimental models and their use in studies of diabetic retinal microangiopathy by Bazan, N G, Gordon, W C, Marcheselli, V L, Lukiw, W J, Duhault, J, Koenig-Berard, E, Linn, D M, DeCoster, M A, Mukherjee, P K

“…Diabetes produces dramatic changes in retinal microvasculature, triggering endothelial cell proliferation and microaneurysms. Capillaries become weakened,…”
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Lipocalin-Type Prostaglandin D Synthase (beta -Trace) Is Located in Pigment Epithelial Cells of Rat Retina and Accumulates within Interphotoreceptor Matrix by Beuckmann, Carsten T, Gordon, William C, Kanaoka, Yoshihide, Eguchi, Naomi, Marcheselli, Victor L, Gerashchenko, Dimitry Y, Urade, Yoshihiro, Hayaishi, Osamu, Bazan, Nicolas G

“…Glutathione-Independent prostaglandin D synthase, identical to beta-trace, (a major CSF protein), is localized in the CNS. This enzyme, lipocalin-type…”
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Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs by Vaccarino, Anthony L., Paul, Dennis, Mukherjee, Pranab K., Rodríguez de Turco, Elena B., Marcheselli, Victor L., Xu, Liang, Trudell, Mark L., Minguez, J.M., Matía, M.P., Sunkel, Carlos, Alvarez-Builla, Julio, Bazan, Nicolas G.

“…A series of acetaminophen (APAP) analogs, 2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3 H)-yl)- N-(4-hydroxyphenyl)alkanecarboxamides, bearing a heterocyclic…”
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Inducible prostaglandin synthase in cell injury by Bazan, N G, Marcheselli, V L, Mukherjee, P K

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Composition and labeling by [3H]glycerol and [3H]serine of phospholipids of the chicken retina and optic tectum by Marcheselli, V L, Giusto, N M

“…The content and fatty acid composition of phospholipids and the in vivo labeling of lipids by [3H]glycerol and [3H]serine was studied in the retina and the…”
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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease by Lukiw, Walter J, Cui, Jian-Guo, Marcheselli, Victor L, Bodker, Merete, Botkjaer, Anja, Gotlinger, Katherine, Serhan, Charles N, Bazan, Nicolas G

“…Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed…”
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Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling by Mukherjee, Pranab K, Marcheselli, Victor L, Barreiro, Sebastian, Hu, Jane, Bok, Dean, Bazan, Nicolas G

“…Integrity of retinal pigment epithelial cells is necessary for photoreceptor survival and vision. The essential omega-3 fatty acid, docosahexaenoic acid,…”
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Rapid Glucocorticoid-Mediated Endocannabinoid Release and Opposing Regulation of Glutamate and γ-Aminobutyric Acid Inputs to Hypothalamic Magnocellular Neurons by Di, Shi, Malcher-Lopes, Renato, Marcheselli, Victor L, Bazan, Nicolas G, Tasker, Jeffrey G

“…Glucocorticoids secreted in response to stress activation of the hypothalamic-pituitary-adrenal axis feed back onto the brain to rapidly suppress…”
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Arachidonic acid metabolism and cerebral blood flow in the normal, ischemic, and reperfused gerbil brain. Inhibition of ischemia-reperfusion-induced cerebral injury by a platelet-activating factor antagonist (BN 52021) by Panetta, T, Marcheselli, V L, Braquet, P, Bazan, N G

“…Cerebral ischemia and ischemia-reperfusion induced cerebral injury results in the accumulation of free fatty acids and diacylglycerols as a result of increased…”
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Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils by Marcheselli, Victor L, Mukherjee, Pranab K, Arita, Makoto, Hong, Song, Antony, Rajee, Sheets, Kristopher, Winkler, Jeremy W, Petasis, Nicos A, Serhan, Charles N, Bazan, Nicolas G

“…Abstract Retinal pigment epithelial (RPE) cells, derived from the neuroectoderm, biosynthesize the novel lipid mediator neuroprotectin D1 (NPD1) from…”
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Brain response to injury and neurodegeneration: endogenous neuroprotective signaling by Bazan, Nicolas G, Marcheselli, Victor L, Cole-Edwards, Kasie

“…Synaptic activity and ischemia/injury promote lipid messenger formation through phospholipase-mediated cleavage of specific phospholipids from membrane…”
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