Search Results - "Marchese, Emanuela"
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Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
Published in Scientific reports (03-02-2021)“…In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world…”
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Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era
Published in Molecules (Basel, Switzerland) (01-10-2023)“…Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical…”
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3
Influence of Sex on Urinary Organic Acids: A Cross-Sectional Study in Children
Published in International journal of molecular sciences (16-01-2020)“…The characterization of urinary metabolome, which provides a fingerprint for each individual, is an important step to reach personalized medicine. It is…”
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Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line
Published in International journal of molecular sciences (13-11-2018)“…Methylmalonic acidemias (MMAs) are inborn errors of metabolism due to the deficient activity of methylmalonyl-CoA mutase (MUT). MUT catalyzes the formation of…”
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5
Exploring Key Challenges of Understanding the Pathogenesis of Kidney Disease in Bardet–Biedl Syndrome
Published in Kidney international reports (01-09-2020)“…Bardet–Biedl syndrome (BBS) is a rare pleiotropic inherited disorder known as a ciliopathy. Kidney disease is a cardinal clinical feature; however, it is one…”
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Multi-Omics Studies Unveil Extraciliary Functions of BBS10 and Show Metabolic Aberrations Underlying Renal Disease in Bardet–Biedl Syndrome
Published in International journal of molecular sciences (20-08-2022)“…Bardet–Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy resulting in multiple organ dysfunctions, including chronic kidney disease (CKD). Despite…”
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New Insights for Polyphenolic Compounds as Naturally Inspired Proteasome Inhibitors
Published in Pharmaceuticals (Basel, Switzerland) (01-12-2023)“…Polyphenols, an important class of natural products, are widely distributed in plant-based foods. These compounds are endowed with several biological…”
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The 2022 European Union report on pesticide residues in food
Published in EFSA journal (01-04-2024)“…Under European Union legislation (Article 32, Regulation (EC) No 396/2005), the European Food Safety Authority provides an annual report assessing the…”
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9
Proteomic Analysis of Mucopolysaccharidosis IIIB Mouse Brain
Published in Biomolecules (Basel, Switzerland) (26-02-2020)“…Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of α-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage…”
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10
In Silico and In Vitro Study of Antioxidant Potential of Urolithins
Published in Antioxidants (01-03-2023)“…In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut…”
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Thymic stromal lymphopoietin-stimulated CD4 + T cells induce senescence in advanced breast cancer
Published in Frontiers in cell and developmental biology (17-11-2022)“…Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4 T…”
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Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
Published in iScience (18-11-2022)“…Chronic kidney disease (CKD) is a major clinical sign of patients with Bardet-Biedl syndrome (BBS), especially in those carrying BBS10 mutations. Twenty-nine…”
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An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology
Published in Frontiers in cell and developmental biology (2023)“…Polyphenolic compounds constitute a diverse group of natural components commonly occurring in various plant species, known for their potential to exert both…”
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Posttranslational protein modifications as gatekeepers of cancer immunogenicity
Published in The Journal of clinical investigation (15-05-2024)“…Triple-negative breast cancer (TNBC) presents a formidable challenge in oncology due to its aggressive phenotype and the immunosuppressive nature of its tumor…”
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Hypermethioninemia in Campania: Results from 10 years of newborn screening
Published in Molecular genetics and metabolism reports (01-12-2019)“…In the last years tandem mass spectrometry (MS/MS) has become a leading technology used for neonatal screening purposes. Newborn screening by MS/MS on dried…”
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P0031AURINE METABOLOMICS: AN EMERGING TOOL FOR DISSECTING BIOLOGICAL ABERRATIONS UNDERLYING RENAL DYSFUNCTION IN BARDET-BIEDL SYNDROME
Published in Nephrology, dialysis, transplantation (01-06-2020)“…Abstract Background and Aims Bardet Biedl Syndrome (BBS) is a rare genetic disorder characterized by a wide range of organ dysfunction, including kidney…”
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On the dual role of (+)-catechin as primary antioxidant and inhibitor of viral proteases
Published in Computers in biology and medicine (01-09-2024)“…Natural antioxidants have become the subject of many investigations due to the role that they play in the reduction of oxidative stress. Their main scavenging…”
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Proteomics and metabolomics studies exploring the pathophysiology of renal dysfunction in autosomal dominant polycystic kidney disease and other ciliopathies
Published in Nephrology, dialysis, transplantation (01-11-2020)“…The primary cilium (PC) was considered as a vestigial organelle with no significant physiological importance, until the discovery that PC perturbation disturbs…”
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Discovery of pyridoquinoxaline-based new P-gp inhibitors as coadjutant against Multi Drug Resistance in cancer
Published in European journal of medicinal chemistry (05-10-2024)“…Multi-drug resistance (MDR) is a serious challenge in contemporary clinical practice and is mostly responsible for the failure of cancer medication therapies…”
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CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation
Published in The Journal of experimental medicine (04-07-2022)“…Cancer immunology research is largely focused on the role of cytotoxic immune responses against advanced cancers. Herein, we demonstrate that CD4+ T helper…”
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