Search Results - "Marchenko, N D"

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis by Li, D, Marchenko, N D, Moll, U M

“…Mutant p53 (mutp53) cancers are surprisingly dependent on their hyperstable mutp53 protein for survival, identifying mutp53 as a potentially significant…”
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Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding by Marchenko, N D, Hanel, W, Li, D, Becker, K, Reich, N, Moll, U M

“…The activity of p53 as an inducible transcription factor depends on its rapid nuclear stabilization after stress. However, surprisingly, mechanism(s) that…”
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HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer by Schulz, R, Streller, F, Scheel, A H, Rüschoff, J, Reinert, M-C, Dobbelstein, M, Marchenko, N D, Moll, U M

“…Overexpression of the human epidermal growth factor receptor-2 (HER2) in breast cancer strongly correlates with aggressive tumors and poor prognosis. Recently,…”
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p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis by Yallowitz, A R, Alexandrova, E M, Talos, F, Xu, S, Marchenko, N D, Moll, U M

“…In embryogenesis, p63 is essential to develop mammary glands. In the adult mammary gland, p63 is highly expressed in the basal cell layer that comprises…”
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Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma by Becker, K, Marchenko, N D, Maurice, M, Moll, U M

“…Neuroblastoma (NB) is the most common solid malignancy in childhood and its prognosis is still generally poor. In contrast to many other cancers, mutations of…”
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Mitochondrial death functions of p53 by Marchenko, N D, Moll, U M

“…The p53 tumor suppressor network plays a fundamental surveillance role in both homeostatic and adaptive cell biology. p53 is one of the most important barriers…”
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Long-Chain Alkenones in Sediments of Lake Utichye-3 (Southern Siberia, Khakassia) as a Paleo-Indicator of Climate Change by Bulkhin, A. O., Zykov, V. V., Marchenko, D. N., Kalugin, I. A., Rogozin, D. Y.

“…Long-chain alkenones are produced exclusively by certain species of microalgae Isochrysidales of the order of haptophytes (Haptophyta). These are…”
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Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors by Vaseva, A V, Yallowitz, A R, Marchenko, N D, Xu, S, Moll, U M

“…Strategies to induce p53 activation in wtp53-retaining tumors carry high potential in cancer therapy. Nutlin, a potent highly selective MDM2 inhibitor, induces…”
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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling by Marchenko, N D, Zaika, A, Moll, U M

“…The mechanism of p53-mediated apoptosis after cellular stress remains poorly understood. Evidence suggests that p53 induces cell death by a multitude of…”
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Cytological substantiation of application of vacuum therapy in combustiology by Bogdanov, S. B., Marchenko, D. N., Pavlyk, K. C., Gospirovish, O. V., Artemova, E. A., Myhanov, M. L.

“…The OBJECTIVE was to perform a comparative cytological analysis of the wound exudate in healing wounds during autodermoplasty on a granulating burn wound with…”
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Loss of p53 function in uterine papillary serous carcinoma by Kovalev, Sergey, Marchenko, Natalie D., Gugliotta, Biagio G., Chalas, Eva, Chumas, John, Moll, Ute M.

“…In contrast to endometrioid carcinoma, uterine papillary serous carcinoma (UPSC) is an aggressive type of endometrial cancer. Loss of p53 function is critical…”
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Novel ways of vacuum therapy application in burn injury medicine by Bogdanov, S. B., Marchenko, D. N., Polyakov, A. V., Karakulev, A. V., Bogdanova, Yu. A.

“…Aim. To develop and improve new ways of surgical treatment for deep burn injuries and their consequences with use of vacuum therapy and cell technologies…”
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Improvement of Surgical Treatment for Post-Ambustial Cicatrical Deformations Using Vacuum Therapy by Bogdanov, S. B., Marchenko, D. N., Polyakov, A. V., Karakulev, A. V., Aladyina, V. A.

“…Background Improvement of treatment results in patients with cicatrical deformations by means of new surgical techniques and vacuum dressings is the aim of…”
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SURGICAL ASPECTS OF FULL-THICKNESS SKIN AUTOGRAFT ENGRAFTMENT ON A GRANULATING WOUND by Bogdanov, S. B., Aladina, V. A., Marchenko, D. N., Polyakov, A. V., Melkonyan, K. I., Gilevich, I. V., Bogdanova, Yu. A.

“…Background. The paper presents the clinical results of treating patients using full-thickness skin autografts for granulating wounds. Objective. To study the…”
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Overexpression of the wild type p73 gene in breast cancer tissues and cell lines by ZAIKA, A. I, KOVALEV, S, MARCHENKO, N. D, MOLL, U. M

“…The p73 gene is a structural and, in overexpression systems, functional p53 homologue. Ectopic p73 expression can activate a broad subset of p53-responsive…”
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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking by Stommel, Jayne M., Marchenko, Natalie D., Jimenez, Gretchen S., Moll, Ute M., Hope, Thomas J., Wahl, Geoffrey M.

“…Appropriate subcellular localization is crucial for regulating p53 function. We show that p53 export is mediated by a highly conserved leucine‐rich nuclear…”
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PREVENTION OF HEART FAILURE PATIENTS WITH DECREASED EJECTION FRACTION IN NON-CARDIAC SURGERY: LEVOSIMENDAN OR ANESTHETIC CARDIOPROTECTION? by Likhvantsev, V V, Marchenko, D N, Grebenshchikov, O A, Ubasev, Yu V, Zabelina, T S, Timoshin, S S, Skripkin, Yu V, Ovezov, A M, Lar'kov, R N, Philippovskaya, Zh S, Sungurov, V A

“…Chronic heart failure (CHF) significantly worsens the prognosis of surgical treatment in noncardiac surgery, doubling mortality in compared with patients with…”
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Preoperative Prevention of Heart Failure in Noncardiac Surgery by Likhvantsev, V. V., Ubasev, Yu. V., Skripkin, Yu. V., Zabelina, T. S., Sungurov, V. A., Lomivorotov, V. V., Marchenko, D. N.

“…Congestive heart failure is consistently associated with adverse outcomes, and is characterized by a twofold increase in mortality in noncardiac surgery. In…”
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Nuclear overexpression of p53 protein does not correlate with gene mutation in primary peritoneal carcinoma by Marchenko, Natalia D, Moll, Ute M

“…Primary peritoneal carcinoma (PPC) is an aggressive malignancy of the female coelomic epithelium. Previously we had analyzed 29 cases of PPC for p53 protein…”
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Hypoxia death stimulus induces translocation of p53 protein to mitochondria: Detection by immunofluorescence on whole cells by Sansome, Christine, Zaika, Alex, Marchenko, Natalie D, Moll, Ute M

“…Evidence suggests that p53 induces cell death by a dual mode of action involving activation of target genes and transcriptionally independent direct signaling…”
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